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Comparative study of the mode of action of clinically approved platinum-based chemotherapeutics

Platinum drugs are among the most effective anticancer agents, but their mode of action is still not fully understood. We therefore carried out a systematic investigation on the cellular activities of cisplatin, carboplatin and oxaliplatin in A498 kidney cancer cells. Cytotoxicity was higher for cisplatin and oxaliplatin compared to carboplatin, with induction of apoptosis as the preferred mode of

Perceived job strain among Swedish occupational therapists with less than 10 years of work experience

Background: Occupational therapists with less than 10 years of work experience have been shown to be at higher risk of work-related stress. There is a need for further research on the level of job strain they perceive. Aims: To investigate the perceived level of job strain among Swedish occupational therapists with less than 10 years of work experience and differences between groups who have worke

Identifying Critical Components of Electric Power Systems: A Network Analytic Approach

We propose a method for identifying and ranking critical components and sets of components in technical infrastructures. Criticality is defined as the vulnerability of the system to failure in a specific component, or set of components. The identification of critical components is increasingly difficult when considering multiple simultaneous failures, especially component failures with synergistic

Retirement – a new beginning or the beginning of the end?

The chapter explores what retirement means to women about to, or having recently retired in the current economic climate. It examines the choices perceived available to pre-retirement and retired people and their attitudes towards retirement. From our findings we are able to deduce that not everyone approaches retirement in the same way. Davies and Jenkins (2013) categorize individual-level experi

The Swedish experience of rehabilitation robotics

Over the last ten years, there has been a great deal of research and development in Sweden in the field of rehabilitation robotics. The research effort has often focused on workplace adaptations. This paper deals with four robotic adaptations, all of whic

Scholarly publishing: one practice between the two systems of communication and academic meriting

The aim of this paper is to highlight and discuss the complexities of scholarly publishing being a practice closely relating to two different systems, the system of academic merit and the system of scholarly communication, by showing how the two systems work on different sets of logic and therefore needs to be analyzed in different ways and using different kinds of data. These complexities are dis

Images of Devotion in Swedish Wall Paintings

In the first paper, devotional activities such as praying and worshipping in wall paintings, will be analysed. The wall paintings were the illiterate man's manual where he was taught the essentials of Christian faith and devotion.

Amorphous silica transport in the Ganges basin: Implications for Si delivery to the oceans

Rivers transport similar to 6 x 10(12) mol yr(-1) of dissolved Si (DSi) from the continents to the oceans. They also carry amorphous silica (ASi), solid phases likely to dissolve in seawater. Unfortunately, the magnitude of this flux is poorly constrained at a global scale. We present 92 new ASi values from suspended particulate matter (SPM) from the Ganges basin. Bulk SPM is 1.2% ASi, and mean AS

File-Sharing – A Threat to Intellectual Property Rights, or is the Music Industry Just Taking Us for a Spin?

File-sharing has become synonym with the “digital economy” where large music conglomerates as well as certain artist voice strong concern over the impact on their bottom line. This research analyzes the music industry, which has been heavily impacted by a major technological shift i.e. the invention, and rollout, of the Internet. We look to the technological shift that has enabled the downloading

Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers

BACKGROUND: Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study

Metabolic Characteristics of Invasive Plant Ipomoea cairica in South China by de novo Transcriptomics

To explore the molecular mechanisms of Ipomoea cairica invasiveness insouth China, the de novo transcriptomes from I. cairica and two related species, I. digitata and I. nil,were sequenced and assembled.There were5 6551 all-unigenes obtained by assembling the reads, among them 56522 all-unigenes were annotated, including 7815, 15615, and 180201 all-unigenes in GO, COG and KEGG databases, respectiv