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Reactive oxygen species (ROS) are important in the immune defense against invading pathogens, but they are also key molecules in the regulation of inflammatory reactions. Low levels of ROS production due to a polymorphism in the neutrophil cytosolic factor 1 (Ncf1) gene are associated with autoimmunity and arthritis severity in mouse models induced with adjuvant. We established an adjuvant-free ar

OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs)

54 female breast cancer patients from 22 families with BRCA2 germ line mutations from Sweden and Denmark were compared with 214 age- and date of diagnosis-matched controls identified among breast cancer patients from South Sweden. At diagnosis, BRCA2-associated cases were more often node-positive (N+). OR=1.9 (95% confidence interval (CI)=1.0-3.6; P=0.036), and were more often clinical stage IV: O

In this study we will report on the development of a process to establish antisticking layers on nickel-based stamps, which are used in several industrial applications of nanoimprint lithography or related methods. The fluorinated alkyl silane films have been deposited onto different Ni-based stamp surfaces in order to minimize the adhesion tendency at the stamp/polymer interface. film thickness,

To increase our knowledge of human peripheral vasospasm we characterized the contractile 5-hydroxytryptamine (5-HT) receptors in human superficial hand vein segments in vitro. The 5-HT1 receptor agonist, sumatriptan, the 5-HT2 receptor agonist, dl-alpha-methyl-5-HT, and the 5-HT3 receptor agonist, 2-methyl-5-HT, all induced concentration-dependent contractions. The contractile response to sumatrip

Polyamines (putrescine, spermidine, and spermine) are essential for growth and survival of all cells. When polyamine biosynthesis is inhibited, there is up-regulation of import. The mammalian polyamine transport system is unknown. We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increas

A small release cell, in the form of a rotating disc, has been constructed to fit into the MRI equipment. The present work show that both qualitative and quantitative information of the swelling and erosion behavior of hydrophilic extended release (ER) matrix tablets may be obtained using this release cell and non-invasive magnetic resonance imaging (MRI) studies at different time-points during ma

Structures of Architectural Heritage are constantly exposed to natural and human-made threats that can compromise their cultural and artistic values. This is the case of the Roman city of Pompeii, whose preserving conditions nowadays are so critical to let a group of Unesco-appointed experts consider the possible inscription of the property on the list of “World Heritage in Danger”. In this respec

Haemophilus influenzae is a Gram-negative human pathogen that resides in the upper respiratory tract. Encapsulated H. influenzae type b (Hib) and type f (Hif) are the most common serotypes associated with invasive disease. H. influenzae displays various strategies to circumvent the host innate immune response, including the bactericidal effect of the complement system. In this study, we identified

We have examined the effect of geometry optimisation on energies calculated with the quantum-mechanical (QM) cluster, the combined QM and molecular-mechanics (QM/MM), the big-QM approaches (very large single-point QM calculations taken from QM/MM-optimised structures, including all atoms within 4.5 Å of the minimal active site, all buried charged groups in the protein, and truncations moved at lea

Adults with repaired tetralogy of Fallot and significant chronic pulmonary regurgitation are at risk for progressive right ventricular (RV) dilatation and dysfunction. The assessment of RV function is important in the management in these patients. There is still a lack of an adequate geometric model to quantify RV function by echocardiography. The myocardial performance index (MPI) is a nonvolumet

Education for sustainability (EfS) has been regarded a promising approach for solving sustainability challenges. Results have been unsatisfying due to a knowledge-dissemination focus in the formal sector. Reasons are economic and political interests shaping formal education. Therefore, hopes are placed in the non-formal sector to close this knowledge-to-action gap. In this case study, I aim to und

Bakgrund: OF Ekeri är ett nationellt företag med kontor i Markaryd. De levererar och hyr ut ett stort utbud av olika typer av lastbilssläp som till exempel släpvagnar, påhängsvagnar och reservdelar. Nästan alla företag i dag har någon form av informationssystem, men många av dem är ineffektiva. OF Ekeri är medvetna om att deras sätt att hantera deras information inte är uppdaterad och därför de haBackground: OF Ekeri is a national company with an office in Markaryd. They deliver and rent a wide selection of different types of truck trailers, semitrailers and spare parts. Today almost all companies have some kind of information system and many of them are inefficient. OF Ekeri is aware of that their way of managing their information is not up to date and therefore they have asked for help r

Sedan 2015 har Sverige en uttalat feministisk utrikespolitik, med målet att ett genusperspektiv ska genomsyra all politisk verksamhet. Parallellt med denna nya politiska inriktning fortsätter Sverige att exportera krigsmateriel till icke-demokratiska och konfliktdrabbade stater, något som har gett upphov till kritik. Genom att granska den statliga myndighet som ansvarar för beslut om krigsmateriel

Syftet med denna studie är att undersöka vilken effekt ett medlemskap i den Europeiska unionen har haft på Sveriges politiska partiers kommunikation. För att genomföra undersökningen har vi använt de politiska partierna i Norge som referenspunkt. Denna studie använder sig av ”theory of Europeanization” och ”Greens theory of Salience Issues” som teoretisk grund för att försöka förklara den förändri

På bangården i Nässjö har det mellan 1918 och 2005 legat en impregneringsanläggning för järnvägsslipers. Som impregneringsmedel användes främst kreosotolja vilket innehåller polycykliska aromatiska kolväten (PAH) som kan vara skadliga för människa och natur. Marken på bangården är nu kraftigt förorenad och ska därför saneras. Tyréns AB har på uppdrag av Trafikverket tagit fram ett förfrågningsundA facility for preservation of wooden rail road sleepers has been operating at the railway yard in Nässjö between 1918 and 2005. The main preservative used at the site was creosote which contains polycyclic aromatic hydrocarbons (PAH) that can be harmful to humans and the environment. The soil at the railway yard is due to these activities heavily polluted and the Swedish Transport Administration

This study investigates whether Swedish students, at two different levels of study, are able to distinguish between ‘it’ and ‘there’ when using the two as dummy subjects. This particular feature was chosen since previous research (e.g. Estling- Vannestål, 2007; Köhlmyr, 2003; Davidsen-Nilsen & Harder, 2001 ) has shown that Swedish students tend to overuse ‘it’ in such constructions: something

There has been a decrease in sea ice extent and volume in the polar regions during the past decades; this study focuses on the Northern Hemisphere. The variability of the sea ice extent along the east coast of Greenland is examined and the area is divided into three regional zones to be able to study variations in the correlation strength along the coast. The ice extent along the east coast is ach

Syftet med studien är att undersöka vilken roll takt och rytm spelar i en idrottslärares undervisning. För att förtydliga uppsatsens syfte och beskriva idrottslärarnas uppfattning behandlas följande forskningsfrågor: Hur ser idrottslärare på takt och rytm i sin undervisning? Vad uppfattar idrottslärare att det är de ska undervisa i när det gäller takt och rytm enligt kursplanen? Hur ser idrottslärMeasure and rhythm: What part do concepts of measure and rhythm play in a physical education teachers way of teaching? The purpose of this study is to determine what part the measure and rhythm plays in a physical education teacher's way of teaching. To clarify the purpose of this study and describe physical education teachers' perception, the following research questions are processed: Ho

This thesis deals with religion in the secular and democratic state. To demonstrate the complex tension between the freedom of religion and secular principles, Jürgen Haber-mas's theories about the post-secular society has been used to implement a critical dis-course analysis which examines five debating articles that specifically focuses on the question about the call to prayer for Muslims in