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Genetic characterization of families with von Willebrand disease

von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise to a classification scheme that divides the disease into three types according to how it is manifest

Development and validity of a universal empirical equation to predict skin surface temperature on thermal manikins

Clothing evaporative resistance is an important input in thermal comfort models. Thermal manikin tests give the most accurate and reliable evaporative resistance values for clothing. The calculation methods of clothing evaporative resistance require the sweating skin surface temperature (i.e., options 1 and 2). However, prevailing calculation methods of clothing evaporative resistance (i.e., optio

A Prototyping Method to Simulate Wearable Augmented Reality Interaction in a Virtual Environment - A Pilot Study

Recently, we have seen an intensified development of head mounted displays (HMD). Some observers believe that the HMD form factor facilitates Augmented Reality (AR) technology, a technology that mixes virtual content with the users' view of the world around them. One of many interesting use cases that illustrate this is a smart home in which a user can interact with consumer electronic devices thr

Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters

Background and Purpose 1-adrenoceptor (-AR) antagonists may facilitate ureter stone passage in humans. We aimed to study effects by the 1A-AR selective antagonist silodosin (compared to tamsulosin and prazosin) on ureter pressures in a rat model of ureter obstruction, and on contractions of human and rat isolated ureters. Experimental Approach After ethical approval, ureters of male rats were cann

Bodily Mimesis and the Transition to Speech

The chapter reviews evidence for the bodily mimesis hypothesis, which states that the evolution of language was preceded by an adaptation for improved volitional control of the body, giving our ancestors advantages in the domains of imitation, empathy, and gestural communication. Much of this evidence is also shared by other gesture-first theories of language origins, but they face the problem of

Particle-based likelihood inference in partially observed diffusion processes using generalised Poisson estimators

This paper concerns the use of the expectation-maximisation (EM) algorithm for inference in partially observed diffusion processes. In this context, a well known problem is that all except a few diffusion processes lack closed-form expressions of the transition densities. Thus, in order to estimate efficiently the EM intermediate quantity we construct, using novel techniques for unbiased estimatio

Host response in sepsis

Sepsis is a serious condition characterized by a systemic inflammatory response to an infection. Increased vascular leakage, vasodilation and heart failure cause circulatory disturbances challenging the intensivist. Despite modern medication and high technology supportive care, mortality is high. Key strategies include to find and take care of causative agents at the infection site. Unfortunately,

A Study on Local Cooling of Garments with Ventilation Fans and Openings Placed at Different Torso Sites

Abstract in UndeterminedThe aim of the study was to examine the various design features of ventilatedgarments on cooling performance. Five jackets with small ventilation units andclosable openings were designed. The ventilation units with a flow rate of 12 l/s wereplaced at five different torso sites. They were examined on a sweating thermalmanikin in four clothing opening conditions in a warm env

Haemophilus influenzae interacts with the human complement inhibitor factor H

Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F

Urban geographic information systems : the city of Berkeley Pilot GIS

Of all information gathered and maintained by a small municipality, in this case the city of Berkeley, California, the percentage that is somehow geographically related is usually very high. The key to an efficient land management and analysis system is to link information gathered by a municipality's administration to its actual geographic locations; locations that together form the complexit

Managing Coordination in global projects

Coordinating global projects with resources from all around the world is more dependent of the team members´ background, attitude and personality rather than cultural differences. The projects that gave the apprehension of working in a team instead of a group of people resulted in more successful projects. The projects that were the most complex to manage, with resources from different offices and

Decemberdomarna i all ära men vad händer egentligen efter Peru? - när har skatteavtal inte företräde framför nationell rätt?

Till varje stats suveränitet hör utformningen av dess beskattning. Eftersom flertalet stater använder sig av olika principer vid bestämmandet av beskatt-ningsanspråken leder detta ofta till dubbelbeskattning för företag och indivi-der. Motverkandet av den ofördelaktiga beskattningen sker genom en till-lämpning av skatteavtal då deras syfte primärt är att undanröja eller lindra följderna av internaDesigning of the taxation system belongs to the sovereignty of each state. Since most states use different principles in determining the taxable claims, this often leads to double taxation of companies and individuals. The avoid-ance of the unfavorable taxation is made through the practice of tax treaties, as their primary purpose is to eliminate or mitigate the consequences of in-ternational judi

The (S)wedish idea of security: idealism or realism?

Since regaining power in 2014, the Swedish Social Democratic party has pushed a security policy line combining increased spending on the Swedish armed forces and deepened international cooperation while at the same time maintaining the policy of military non-alignment. This tripartite strategy has been nicknamed the “Hultqvist Doctrine" after the current Swedish Minister for Defence. During t

Commuting in a crisis: A case study of mobility behavior during the COVID-19 pandemic in Malmö, Sweden

The COVID-19 pandemic impacted people’s behavior on many levels, one of which is the frequency of commuting and the mode of transportation (MOT) used for it. This case study analyzes mobility behavior during the pandemic of employees commuting to and in Malmö, Sweden, and its predicting factors. A quantitative online survey (n=94) and qualitative semi-structured interviews (n=8) were conducted bas

Vårdnadsöverflyttning i svensk rätt -förenligt med artikel 8 i Den europeiska konventionen angående skydd för de mänskliga rättigheterna och grundläggande friheterna?

Utgångspunkten för följande uppsats är dynamiken mellan Föräldrabalken, FB, 6:8 och artikel 8 Den europeiska konventionen angående skydd för de mänskliga rättigheterna och de grundläggande friheterna, EKMR. FB 6:8 innebär ett ingrepp i familjen då vårdnaden om ett barn flyttas över på någon utanför familjen. Detta ingrepp i familjen som FB 6:8 medför innebär inte enkom att den faktiska vårdnaden ö

Makroekonomiska variablers påverkan på Dow Jones och OMXS30

Syftet med studien är att undersöka makroekonomiska variablers effekt på Dow Jones och OMXS30, med hjälp av en lämplig ekonometrisk modell. Vidare är syftet att analysera möjligheten för börsprognostisering och analysera om denna möjlighet är lika stor för Dow Jones som för OMXS30. Detta kommer att ske genom att undersöka motsvarande variabler för respektive lands aktieindex. Variablerna arbetslös

Turnaroundarbete i hyperkonkurrens - En fallstudie av SAS Sverige AB

Syftet med den här uppsatsen är att åskådliggöra hur SAS Sverige AB:s turnaroundarbete i en hyperkonkurrens samt hur bolaget försökt återskapa lönsamhet med nya strategiska verktyg. För att kunna svara på vår frågeställning utgick vi från en branschanalys för att förklara orsakerna till att ett behov av turnaround uppstod. För att sedan analysera turnaroundarbetet användes klassiska teorier inom t

Att byta affärssystem - en fallstudie på AB Sardus

Implementering av integrerade affärssystem har blivit allt vanligare. Många forskningsprojekt har fokuserat på användarna och hur de har upplevt systemen. Vår fallstudie av Sardus byte av affärssystem syftar till att se hur arbetsprocess och kravformulerande vid val av affärssystem är viktiga faktorer för hur väl systemen faller ut. Arbetsprocessen förutsätter en väl sammansatt projektgrupp med re

Corporate Branding vid förvärv - en fallstudie av Matex/Willys i Lund

Syftet med vår uppsats är att undersöka och analysera hur en koncern via Corporate Branding integrerar och implementerar ett redan existerande koncept i ett förvärvat företag/kedja. Då Corporate Branding handlar om att bygga upp, förstärka och förmedla ett affärskoncept till både interna och externa intressenter, har vi, för att ge en heltäckande bild av processen, valt att undersöka och analysera

Knowledge and focus, a condition for continuing sales growth

Problem discussion: To be competitive in a changeable environment, as the video surveillance market, in a time when the company and the market grow with almost 40% yearly, the sales organization must be well trimmed and effective. Knowledge about customers’ needs and what makes success are essential parts of the progress. Sales Product Management (Sales PM) is a new group at Axis with the main tas