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Purpose – The purpose of this paper is to systematically and critically review the extant literature on the design of global production and distribution networks to identify gaps in the literature and identify future research opportunities. The design aspects deal with strategic and structural decisions such as: opening or closing of manufacturing plants or distribution centres, selection of locat
OBJECTIVE: To assess the outcome of vacuum-assisted wound closure (VAC(®)) therapy for infected bypass grafts. METHODS: A retrospective 7-year review of patient records from 2004 to 2011 of all patients receiving VAC(®) therapy for infected bypass grafts. RESULTS: Thirty-seven patients with 42 wounds and 45 infected bypass (28 synthetic) grafts received VAC(®) treatment. Two serious bleeding e
The tyrosine kinase encoding genes ABL1 and FGFR1 are involved in fusion genes underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, chronic phase that after some time progresses into acute myeloid or lymphoid leukemia. The mechanisms under
This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well
The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. The sequence was found to have bidirectional activity and is likely to regulate also RHBD
Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathol
Background: The healthcare sector needs to deliver evidence-based care and be cost-effective. This can be monitored in part via a national quality registry containing individualized data concerning patient problems, medical interventions, outcomes of treatment, and patient-reported outcomes. With this aim, Web Rehab Sweden was launched in 1997 and has been available online since 2007. The aim of t
Laser-ablated group 6 metal atoms react with NF3 and PF3 to form the simple lowest energy N MF3 and P=MX3 products, and this investigation has been extended to AsF3. Mo and W atoms react with AsF3 upon excitation by laser ablation or UV irradiation to form stable trigonal As MF3 terminal arsenides. These molecules are identified by comparison of the closely related infrared spectra of the analogou
BACKGROUND: Antimicrobial peptides (AMPs) are important actors in the innate immune system. One class of AMPs is the human β-defensins (HBDs), a group of small peptides with a broad spectrum of antimicrobial activities. Expression of HBDs is downregulated in different manifestations of allergic disease. In this study, we examine whether allergen-specific immunotherapy (ASIT) affects the nasal leve
In this article, we study the n - pi* electronic transition in aqueous microsolvated formaldehyde using the coupled cluster (CC) and coupled cluster/molecular mechanics (CC/MM) methods. The CC models used are the coupled cluster singles and doubles (CCSD) and the coupled cluster second-order approximate singles and doubles (CC2) methods. The CC/MM model includes electrostatic and mutual polarizati
The short- and long-term effects of heavy-resistance training (85% of one-repetition maximum (RM)) on elbow flexion and knee extension dynamic and isokinetic strength and on morphology in the biceps brachii and vastus lateralis muscles were evaluated during 1 year in 35 Scandinavian men and women, aged 70-77 years, 12 of whom formed a control group. After the first 11 weeks of training (n = 23; 3
C4b-binding protein (C4BP) is an important plasma inhibitor of the classical pathway of complement activation. Several bacterial pathogens bind C4BP, which may contribute to their virulence. In the present report we demonstrate that isolated type IV pili from Neisseria gonorrhoeae bind human C4BP in a dose-dependent and saturable manner. C4BP consists of seven identical alpha-chains and one beta-c
It is proved that existence of a density function is both necessary and sufficient for almost global stability in a nonlinear system.
The activities of hepatic lipase and of lipoprotein lipase, the elimination rate of exogenous triglyceride and the cholesterol esterification rate were determined and related to plasma lipoprotein concentrations in 16 patients before and after treatment for hyperthyroidism. The activity of hepatic lipase was significantly higher (65%) before than after treatment, while the activity of lipoprotein
Syftet med denna studie är att undersöka vilken effekt ett medlemskap i den Europeiska unionen har haft på Sveriges politiska partiers kommunikation. För att genomföra undersökningen har vi använt de politiska partierna i Norge som referenspunkt. Denna studie använder sig av ”theory of Europeanization” och ”Greens theory of Salience Issues” som teoretisk grund för att försöka förklara den förändri
På bangården i Nässjö har det mellan 1918 och 2005 legat en impregneringsanläggning för järnvägsslipers. Som impregneringsmedel användes främst kreosotolja vilket innehåller polycykliska aromatiska kolväten (PAH) som kan vara skadliga för människa och natur. Marken på bangården är nu kraftigt förorenad och ska därför saneras. Tyréns AB har på uppdrag av Trafikverket tagit fram ett förfrågningsundA facility for preservation of wooden rail road sleepers has been operating at the railway yard in Nässjö between 1918 and 2005. The main preservative used at the site was creosote which contains polycyclic aromatic hydrocarbons (PAH) that can be harmful to humans and the environment. The soil at the railway yard is due to these activities heavily polluted and the Swedish Transport Administration
This study investigates whether Swedish students, at two different levels of study, are able to distinguish between ‘it’ and ‘there’ when using the two as dummy subjects. This particular feature was chosen since previous research (e.g. Estling- Vannestål, 2007; Köhlmyr, 2003; Davidsen-Nilsen & Harder, 2001 ) has shown that Swedish students tend to overuse ‘it’ in such constructions: something
There has been a decrease in sea ice extent and volume in the polar regions during the past decades; this study focuses on the Northern Hemisphere. The variability of the sea ice extent along the east coast of Greenland is examined and the area is divided into three regional zones to be able to study variations in the correlation strength along the coast. The ice extent along the east coast is ach
Syftet med studien är att undersöka vilken roll takt och rytm spelar i en idrottslärares undervisning. För att förtydliga uppsatsens syfte och beskriva idrottslärarnas uppfattning behandlas följande forskningsfrågor: Hur ser idrottslärare på takt och rytm i sin undervisning? Vad uppfattar idrottslärare att det är de ska undervisa i när det gäller takt och rytm enligt kursplanen? Hur ser idrottslärMeasure and rhythm: What part do concepts of measure and rhythm play in a physical education teachers way of teaching? The purpose of this study is to determine what part the measure and rhythm plays in a physical education teacher's way of teaching. To clarify the purpose of this study and describe physical education teachers' perception, the following research questions are processed: Ho
