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Bikunin is a Kunitz-type proteinase inhibitor, which is cross-linked to heavy chains via a chondroitin sulfate chain, forming inter-alpha-inhibitor and related molecules. Rat bikunin was produced by baculovirus-infected insect cells. The protein could be purified with a total yield of 20 mg/liter medium. Unlike naturally occuring bikunin the recombinant protein had no galactosaminoglycan chain. En
AIM: To investigate the expression of gastrin-releasing peptide (GRP) and GRP-receptor mRNA in non-tumor tissues of the human esophagus, gastrointestinal tract, pancreas and gallbladder using molecular biology techniques. METHODS: Poly A(+) mRNA was isolated from total RNA extracts using an automated nucleic acid extractor and, subsequently, converted into single-stranded cDNA (ss-cDNA). PCR ampli
Coronary heart disease remains an important cause of morbidity and mortality. Much data support the view that social support is associated with coronary heart disease. Participants of the study "Men born in 1914," (414 men) were followed from a baseline measurement in 1982183 until the end of 1996. At baseline, the men answered a questionnaire on social support and participated in a stressful test
Popular Abstract in Swedish Vårt immunförsvar måste ständigt vara redo att försvara oss mot angrepp utifrån. Det måste kunna agera selektivt för att skydda oss mot främmande mikroorganismer som virus och bakterier. Om immunförsvaret istället missbedömer kroppens egna celler för att vara inkräktare och attackerar dessa, inträffar det vi kallar autoimmunitet. De autoimmuna sjukdomarna har ökat överaAim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk marke
In an earlier study, infection of human pancreatic islets with epidemic strains of echovirus (E4, E16, E30), with proven but differently ability to induce islet autoimmunity, resulted either in a severe damage (i.e. E16 and E30) or proceeded without visible changes in infected islets (i.e. E4). In this study, the ability of these strains to replicate in beta cells and the consequence of such an in
Human prostate is now considered a target for vitamin D receptor (VDR) ligands, such as BXL-628. Because BXL-628 inhibited prostate growth without interfering with androgen signaling, it represents a new option for benign prostate hyperplasia (BPH) therapy. However, BPH symptoms are related not only to prostate size, but also to compensatory bladder hypertrophy and eventual overactivity. We now re
Compelling evidence suggests that accumulation and aggregation of alpha-synuclein (α-syn) contribute to the pathogenesis of Parkinson's disease (PD). Here, we describe a novel Bacterial Artificial Chromosome (BAC) transgenic model, in which we have expressed wild-type human α-syn fused to green fluorescent protein (GFP), under control of the mouse α-syn promoter. We observed a widespread and high
BACKGROUND: Liver resection provides the best chance for cure in colorectal cancer (CRC) liver metastases. A variety of factors that might influence survival and recurrence have been identified. Predictive models can help in risk stratification, to determine multidisciplinary treatment and follow-up for individual patients. AIMS: To systematically review available prognostic models described for o
PURPOSE: To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) (3)He gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and examine the reproducibility and volume dependency. MATERIALS AND METHODS: A total of eight healthy volunteers and 16 patients with emphysema were examined after inhalation of HP (3)He gas mixed with nitrogen (N(2)) during b
Diagnosis by screening mammography is considered an independent positive prognostic factor, although the data are not fully in agreement. The aim of the study was to explore whether the mode of detection (screening-detected versus symptomatic) adds prognostic information to the St Gallen molecular subtypes of primary breast cancer, in terms of 10-year cumulative breast cancer mortality (BCM).
Popular Abstract in Swedish I min avhandling har jag sökt den kinesiska barnbokens litterära rötter. Jag har studerat dess utveckling och dess samband med författaren Zhang Tianyi, som enligt den officiella bilden betraktas som en av föregångarna på barnlitteraturens område. Kinesisk barnlitteratur är ett outforskat område, trots att källmaterialet är rikt. Avhandlingen studerar barnlitteratur i eThis thesis investigates the origin of children's literature in China and traces its evolution in connection with the author Zhang Tianyi, who is officially considered as one of the forerunners of Chinese children's literature. Children's literature in China is a little studied field, although the sources for a study are abundant. The thesis studies children's literature in its social context, whi
Popular Abstract in Undetermined Syftet med avhandlingen är dels att undersöka författarbiografin som litterär text, dels att finna en rimlig ståndpunkt i den teoretiska debatt där biografins fiktionalitet har lyfts fram. I inledningen tar jag upp den teoretiska utveckling som rör detta metaperspektiv. För att ge en ram både åt dessa resonemang och mitt eget val av undersökningsobjekt, ger jag ockThe aim of the present thesis is twofold: to examine literary biography as literary text and, on the basis of my findings, to adopt a reasonable perspective on the theoretical debate about the fictionality of such biographies. In my introduction I trace the theoretical developments underlying this metaperspective and supply with an historical survey of literary biography as practised in Sweden. In
By drawing from recent progress in AI, this chapter scrutinises implications of a specific imaginary of automated futures: the possible resurrection of the dead. Necrorobotics is proposed as a field of critical studies on the use of data and design based on one specific dead individual in order to “resurrect” that individual. That is, to mimic or create some level of robotic agency for the sake of
As retail is becoming increasingly digitised in its operation and consumer relationships, much faith is put into automation, prediction and insights drawn from consumer data to shape consumer experiences and expectations. Under the umbrella of data-collection and artificial intelligence (AI), this chapter studies the role of consumer trust in retail personalisation. We draw empirical insights from
Different vegetables--carrots, peas, Brussels sprouts and spinach--were added to a typical Swedish lunch test meal in portions of 96-164 g. The test and the control meals without vegetables were balanced with respect to digestible carbohydrates (59.7 g) and energy (2000 kJ, 475 kcal), and as far as possible also concerning protein and fat. The added vegetables contained 4.4 g dietary fibre. The me
Improving access to SRHR-information and care among refugees and migrants remain a central issue. Countries with strong integration policies have significant reductions in the inequities in sexual and reproductive health outcomes. Securing access to SRHR is linked to the extent to which gender equality is fulfilled, including equal rights for men and women to learn the language and participate in
Crowdfunding in tourism and leisure projects appears to be growing. However, little is known about why individuals participate in incentive crowdfunding from a theoretical perspective. To address the research question, this study aims to compare a theoretically integrated model regarding linkages among antecedents, attribution, trust, and behavior. This study conducted an online survey to collect
