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Background: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognos

Background: Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater caused activation in rat trigeminal ganglion (TG) which was abolished by a systemic administration of kynurenic acid (KYNA) derivate (SZR72). Here, we hypothesize that this activa

Light-frame timber buildings are often stabilized against lateral loads by using diaphragm action of roofs, floors and walls. The mechanical behavior of the sheathing-to-framing joints has a significant impact on the structural performance of shear walls. Most sheathing-to-framing joints show nonlinear load-displacement characteristics with plastic behavior. This paper is focused on the finite ele

Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We hypothesized that renal expression of podocyte-specific proteins would be reflected in urinary extracellular vesicles (EVs) of podocyte origin and accompanied by increased urinary soluble nephrin levels (nephrinuria) in preeclampsia. We furth

This study investigates volatility spillovers to electric power from large exogenous shocks in the prices of gas, coal, and carbon emission allowances in the German energy market. Our sample ranges from 2008 to 2016 and covers periods of different market conditions. We use a general VAR-BEKK model and the volatility impulse response function methodology to analyze and evaluate the spillover effect

The distinguishing morphological and chemical characters of nine species of Parmelia Ach. s. str. occurring in the southern Baltic region, namely P. barrenoae Divakar et al., P. ernstiae Feuerer & A. Thell, P. fraudans (Nyl.) Nyl., P. omphalodes (L.) Ach. (including both subspecies P. omphalodes ssp. discordans (Nyl.) Skult and P. omphalodes ssp. omphalodes, P. pinnatifida Kurok., P. saxatilis

Purpose: To examine test–retest reliability and construct validity of the Scandinavian version of the caregiver priorities and child health index of life with disabilities (CPCHILD) questionnaire for children with cerebral palsy (CP). Methods: Families were recruited in Sweden and Norway and stratified according to the gross motor function classification system levels I–V for children born 2000–20

Feminist security studies (FFS) scholarship advocates the analysis of women’s war experiences and narratives to understand conflict and military intervention. Here we add a non-great power focus to FFS debates on the gendered discourses of military interventionism. We zoom in on Danish and Swedish women soldiers’ reflections on their involvement in the ISAF operation in Afghanistan. Their stories

Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of fli

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recov

Background-Treatment with renin-angiotensin system (RAS) inhibitors might restrain the structural/electrical remodeling associated with atrial fibrillation (AF). Limited evidence exists regarding the potential benefits of RAS inhibition post-acute myocardial infarction (AMI) in patients with AF. This study sought to assess the association between RAS inhibition and all-cause mortality and new-onse

In a series of experiments the pyrolytic effects of the heating induced during the hypervelocity impact (HVI) of small projectiles of high TOC mudrock were observed. Impacts at these high speeds (km s-1) release sufficient energy to vaporise metal projectiles, and the temperatures created greatly exceed the pyrolysis temperatures typically employed during laboratory studies of the thermal alterati

Aims To examine whether baseline fasting plasma glucose (FPG) modifies the prognostic role of left ventricular (LV) mass, geometric pattern, and diastolic function, for prediction of cardiovascular morbidity and mortality. Methods Population-based cohort study comprising of 1047 men and 456 women with preserved ejection fraction, included between 2002 and 2006, who underwent echocardiography based

The excellent performance of metal foams is well-recognized in the thermal and energy fields. This paper presents an investigation on the convective heat transfer and thermal performance of microchannel heat sinks with different structures of metal foams, such as Y-shaped, metal foam attached to fins, combined metal foams. The inlet Reynolds number is ranging from 170 to 554 and the porosity of th

Type of Study: This is a longitudinal, case-control clinical trial. Objectives: This study aims to track recovery time following a vocal loading task (VLT) imposing vocal fatigue and to explore if patients with functional dysphonia (FD) are worse affected by vocal loading, and if these patients take longer than others to recover. Methods: Fifty (n = 50) female participants in four vocal subgroups

The objective of the research presented in this paper was to investigate how different characteristics of whey protein microparticles (MWP) added to milk as fat replacers influence intermolecular interactions occurring with other milk proteins during homogenisation and heating. These interactions are responsible for the formation of heat-induced aggregates that influence the texture and sensory ch

The flow field design of current collectors is a significant issue, which greatly affects the mass transport processes of reactants/products inside fuel cells. Especially for proton exchange membrane (PEM) fuel cells, an appropriate flow field design is very important due to the water balance problem. In this paper, a wavy surface is employed at the cathode flow channel to improve the oxygen mass

The Inter-American Court of Human Rights (I-ACtHR) has developed remarkable jurisprudence for the protection of the right to communal property of indigenous and tribal communities with respect to the ancestral lands that they possess and traditionally used-natural resources, in order to guarantee their cultural and economic survival in the Americas. This article critically analyses the legal regim

Flying insects frequently navigate through environments of different complexity. In this study, buff-tailed bumblebees (Bombus terrestris L.) were trained to fly along tunnels of different widths, from 60 to 240 cm. In tunnel widths of 60 and 120 cm, bumblebees control their lateral position by balancing the magnitude of translational optic flow experienced in the lateral visual field of each eye.