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Optogenetic techniques provide powerful tools for bidirectional control of neuronal activity and investigating alterations occurring in excitability disorders, such as epilepsy. In particular, the possibility to specifically activate by light-determined interneuron populations expressing channelrhodopsin-2 provides an unprecedented opportunity of exploring their contribution to physiological and p
Since the fall of the communism, many heated debates about the past took place in Poland, with the stormiest among them concerning not the communist crimes, as one might expect, but the Polish-Jewish relations during the Holocaust and in the immediate post-war years. The most discussed history books in post-communist Poland - “Neighbours” (2000) and “Fear” (2008) by Jan T. Gross dealt with anti-Se
Gaia, the next astrometric mission of the European Space Agency, will use a camera composed of 106 CCDs to collect multiple observations for one billion stars. The astrometric core solution of Gaia will use the estimated location of the stellar images on the CCDs to derive the astrometric parameters (position, parallax and proper motion) of the stars. The Gaia CCDs will suffer from charge transfer
Resource use conflict is an enduring problem for science and policy making. Using in-depth interviews and focus group discussions with resource users, policy makers and key informants, we explored four case examples of resource use conflict within lands and forestry, fisheries, oil and the mining sectors in Ghana. Results indicate that resource use conflict consists of a complex, non-linear system
Popular Abstract in Swedish I det här arbetet studerades kontaktallergi för metaller som finns i olika stentar. Patienterna som ingick i studien hade blivit stentade med olika typer av stentar. En av stentarna var gjord av rostfritt stål (nickelstent) och den andra var förgylld (guldstent). Resultaten av lapptestningen visade att patienterna hade en hög frekvens av både guld- och nickelallergi, ocA large number of patients are treated with coronary stents, and restenosis (recurrent narrowing of the vessel) is a serious problem. Contact allergy to metal ions eluted from stainless steel stents has been suggested to contribute to in-stent restenosis. Studies have reported a higher rate of restenosis with gold-plated stents, but the correlation to contact allergy was not evaluated. Nickel is t
Popular Abstract in Swedish Cancer i urinblåsan är ett stort hälsoproblem i Sverige och världen. Det är den femte vanligaste cancerformen i Sverige och är den som belastar sjukvården med högst kostnader per patient. Ungefär tre fjärdedelar av de drabbade är män och patienterna är oftast kring 60-80 år gamla. Den behandling vi idag kan erbjuda en person som drabbas av blåscancer har inte förändratsDecisions in the treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last ten years, cancer research has seen a gradual transition towards personalized medicine, i.e. the exploi
Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. Fibrinogen concentrate can correct dilutional coagulopathy and has an additional effect when combined with factor XIII concentrate. However, their effect on dilutional coagulopathy concomitant with hypothermia has not been studied previously. Free oscillation rheometr
Two thousand and fourteen saw a drastic increase in asylum seekers knocking on Europe’s door. A great many arrived at Europe’s southern borders, with Italy as the main entrance gate, after having embarked on the dangerous journey across the Mediterranean. Due to the limited number of EU entrance countries and the growing pressure on these southern European countries, the Dublin Regulation, as the
Examensarbetet syftade till att bygga om en industriell press för centrumtegel på Höganäs Bjuf AB, vilket skulle leda till att öka säkerheten för drift- och underhållspersonal. För att öka säkerheten togs ett nytt styrsystem fram bestående av en PLC-baserad styrlogik tillsammans med ett HMI. Det nya styrsystemet kommer att höja arbetssäkerheten för underhållspersonalen då spänningen ute på pressen
This thesis will examine the increased amount of information made available through modern media, and how this affects the diversity in consumption. The thesis will focus on how diversity in music consumption has evolved over the years. There are two contradicting theories that try to describe the impact modern media could have on consumption, the theory of the Long Tail and the Superstar effect.
Sexuella övergrepp mot barn tillhör de mål som är allra svårast att hantera i svenska domstolar. Ofta består bevisningen i målet endast av barnets utsaga, vilket medför svåra bevisvärderingsproblem. Högsta domstolen har i NJA 2010 s. 671 fastslagit ett antal kriterier som kan vara behjälpliga vid bevisvärdering av muntliga utsagor. Vad som bland annat kan beaktas är om utsagan är lång, sammanhängaCases involving child sexual abuse are among the most complex cases for Swedish courts to handle. Evidence often only consists of the child’s statement, which complicates the process of evaluating the evidence. In order to facilitate the evaluation of oral statements the Supreme Court of Sweden established a number of different criteria in its ruling in NJA 2010 s. 671. The statements should for i
Introduction: Occupational balance, a foundational concept in occupational therapy and science, plays a critical role in enhancing health and well-being. Recent studies have revealed its association with epidemiological factors. This study evaluated the validity and reliability of the Japanese version of the Occupational Balance Questionnaire 11 (OBQ11-J). Methods: Adhering to the COnsensus-based
The Islamic Republic of Iran (IRI) has employed assassinations and proxy violence as tools of statecraft. Dissidents in exile have been killed, targeted, or systematically threatened, while Israeli-linked entities across Europe have faced repeated attacks. In recent years, Tehran has increasingly outsourced these operations to state-linked criminal intermediaries. This paper analyzes Iran’s approa
OBJECTIVES: We assessed pharmacodynamic (PD) response for the reduced prasugrel 5-mg maintenance dose in very elderly (≥75y; VE) patients. BACKGROUND: In TRITON-TIMI 38, prasugrel 10-mg reduced ischemic events versus clopidogrel 75-mg, but increased bleeding in VE patients. METHODS: We examined PD and active-metabolite pharmacokinetics with prasugrel 5-mg and 10-mg and clopidogrel 75-mg in a three
AIMS: We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), and comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia.METHODS AND RESULTS: This Danish register study included patients diagnosed with ACS in the period between 1995 and 2013 with a preceding diagnosis o
In this essay we have examined how social workers experience their positions as a public authority person in a society of democracy. As a public officer you have to follow rules and obey the law, which can be difficult if they don't agree with your personal opinion and values. In social work you work with people in a vulnerable situation and it may become extremely demanding to stand between t
The purpose of this essay was to examine the experience of the judicial process concerning domestic violence from the perspectives of abused females and from some of the authorities and organisations which meet these women. The essay investigated several views of the judicial process in order to obtain a wide perspective. It responded to the following questions: - How are abused women treated by
