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Hematopoietic stem cells (HSCs) are thought to reside in discrete niches through stable adhesion, yet previous studies have suggested that host HSCs can be replaced by transplanted donor HSCs, even in the absence of cytoreductive conditioning. To explain this apparent paradox, we calculated, through cell surface phenotyping and transplantation of unfractionated blood, that similar to 1-5% of the t

Popular Abstract in Swedish Neuroblastom är en allvarlig cancerform som nästan enbart drabbar barn. Denna typ av tumörer hittas i vävnader av det sympatiska nervsystemet (vilket är en del av det icke viljestyrda nervsystemet i kroppen). Allra vanligast är det att tumörerna bildas i binjuren, ett organ placerat strax ovanför njuren. Cancer är en komplex sjukdom och varje tumör är speciell på sitt sCells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. It has become evident that HIF-1 and HIF-2 are differentially regulated over time and by oxygen levels. HIF-2α is expressed in a

Background: Spot pricing is considered as a significant supplement for building a full-fledged market economy for the Cloud ecosystem. However, it seems that both providers and consumers are still hesitating to enter the Cloud spot market. The relevant academic community also has conflicting opinions about Cloud spot pricing in terms of revenue generation. Aim: This work aims to systematically ide

Institutional theory of the firm focuses on firm boundaries and the activities firms internalize within their hierarchies. However, an examination of disintegrated firms that influences activities beyond the scope of their hierarchies suggests that firms also perform other economic functions. By analysing these functions, the aim of this paper is to suggest a theory of the firm that goes beyond in

Popular Abstract in Swedish Oönskade reaktioner efter vaccination och allergenspecifik immunoterapi - Kontaktallergi för aluminium och kliande knutor För att ett vaccinationsprogram ska fungera krävs kontinuerlig uppföljning av vaccinernas säkerhet vad gäller eventuella oönskade reaktioner. Under de senaste 10 till 15 åren har en ökad oro noterats bland allmänhet och profession beträffande oönskadThe aim of the work presented in this thesis was to investigate two different types of adverse reactions, persistent itching nodules and contact allergy to aluminium, after immunization with aluminium-containing vaccines and aluminium-containing allergen extracts used for allergen-specific immunotherapy (ASIT). The first paper describes active parental reporting of adverse events (AEFIs) after a

The complement system plays a pivotal protective role in the innate immune response to many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted nonstructural glycoprotein that accumulates in plasma to high levels and is displayed on the surface of infected cells but absent from viral particles. Previous work has defined an immune evasion role of flavivirus NS1

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there h

Popular Abstract in Swedish Drygt en tiondel av Sveriges befolkning lider av hjärt-kärlsjukdom som också är den vanligaste dödsorsaken. Många av de akuta sjukdomstillstånden orsakas av att en bit inflammerad blodkärlsvävnad bryts loss från sitt fäste i något av de stora blodkärlen, färdas med blodet och täpper till blodflödet i mindre blodkärl. Detta leder till syrebrist och celldöd nedströms om dAbstract Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is associated with accumulation of cholesterol, which is an essential component of ce

The objective of this study was to examine to what extent ergonomics simulations of manual assembly tasks correctly predict the real outcomes in the plants and if recommended measures originating from ergonomics simulations are taken into consideration. 155 ergonomics simulation cases were used in the study and all cases were performed by nine simulation engineers at Volvo Car Corporation in Gothe

Popular Abstract in Swedish Ett felaktigt protein som klumpar ihop sig i hjärnans blodkärl är orsaken till hjärnblödning och för tidig död hos unga islänningar. Sjukdomen är ärftlig och uppkommer på grund av en enda felaktig byggsten, orsakad av en mutation, i proteinet cystatin C. Det muterade proteinet bildar mikroskopiska proteinkedjor, fibriller, som klumpar ihop sig i bland annat hjärnans bloThe pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. This has hampered the devel

Aims and objectives. This study aimed to describe and identify risk factors associated with hospital-acquired pressure ulcers among adults in an acute care hospital compared with patients with pre-existing pressure ulcers present on admission. A further aim was to identify the preventive measures performed with both groups respectively. Background. Pressure ulcers occur most often in older and imm

Kulturskolan når över 400 000 barn i Sverige årligen. Institutionen har trots det inget definierat uppdrag på nationell nivå men frågan om vad institutionens uppdrag kan tänkas vara aktualiseras ofta i olika sammanhang. Ett återkommande tema är om Kulturskolan ska förvalta ett kulturarv eller följa marknadsestetiken. Syftet med studien är att ur Kulturskolechefernas perspektiv undersöka KulturskolOver 400,000 children attend Sweden’s Kulturskolor, or municipal schools of music and arts, every year, and yet despite this the schools have no national mission or goals, even though the question of what that mission might be is frequently raised. One common line is that the schools should exist to curate and disseminate cultural heritage; another, that they should bow to market aesthetics. The a

Förorenar Arktiska samhällen sig själva och påverkas marina organismer i samband med detta? Ja, bara i Adventfjorden och Grønfjorden på Svalbard finns förorening från lokala källor för 14 av 57 analyserade flamskydds- och ytbehandlingsämnen i sediment. Inte så mycket tänker kanske du? Men den största anledningen till förekomsten av dessa ämnen är utsläpp av orenat avloppsvatten och läckage från sMost of the ecotoxicological research conducted in the Arctic until today has focused on long range transport of pollutants, while fewer studies on local pollution have been published. The aim of this study was hence to investigate if local pollution of organophosphorus flame retardants (OPFRs), polybrominated diphenyl ethers (PBDEs) and perfluorinated alkylated substances (PFAS) occurs outside tw

This thesis investigates Twitter posting in Greek during the period of the Greek referendum in 2015 and in particular between June 27, when the referendum was announced, and July 6, one day after the referendum was completed, and how the Greek people use various external sources to express themselves (i.e. political thoughts, actions, inquires). The main research question is “What is the role of i

Uppsatsen behandlar kravet på tillräckliga kvalifikationer i 7 §, 22 §, 25 § och 25 a § LAS. Ur ett arbetsrättsligt perspektiv studeras vilka kvalifikationer arbetstagaren måste uppfylla för att åtnjuta rätten till omplacering respektive företräde. Rättspraxis spelar en stor roll i begreppstolkningen då lag och lagmotiv inte bidrar med någon definition av begreppet. I arbetet studeras även om, ochThe essay concerns the requirement of sufficient qualifications in 7 §, 22 §, 25 § och 25 a § LAS. From a labour law perspective the qualifications which the employee has to fulfil to enjoy the right to redeployment and precedence are studied. Case-law is an important source in the interpretation of the concept of sufficient qualifications since its' meaning is not defined by law or preparator

Every year two billion tons of MSW are produced globally. Due to the impact of solid waste and population growth, it is necessary to develop an integrated solid waste management plan. Such a plan, holistic in scope, would aim to minimize the negative impact of this material in the environment while being economically viable. The designation and terming of any one mode of waste treatment as superio