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The EWSR1 gene is known to play a crucial role in the development of a number of different bone and soft tissue tumours, notably Ewing's sarcoma. POU5F1 is expressed during early development to maintain the totipotent status of embryonic stem and germ cells. In the present study, we report the fusion of EWSR1 and POU5F1 in two types of epithelial tumours: hidradenoma of the skin and mucoepidermoid

PURPOSE: We previously reported that a panel of four kallikrein forms in blood-total, free, and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2 (hK2)-can reduce unnecessary biopsy in previously unscreened men with elevated total PSA. We aimed to replicate our findings in a large, independent, representative, population-based cohort. PATIENTS AND METHODS: The study cohort

Thromboxane A(2) (TXA(2)) induces contraction in different smooth muscle types via its receptor (TXA(2) receptor). However, any motoric role of TXA(2) in prostate smooth muscle tone has not been studied to date. Here, we investigated whether TXA(2) induces contraction of human prostate tissue. After ethical approval, prostate tissue was obtained from 47 patients undergoing radical prostatectomy. E

BACKGROUND: Patients with major depressive disorder (MDD) may display elevated plasma levels of pro-inflammatory substances. Although the underlying mechanisms are unknown, inflammation has been proposed to play a direct role in the generation of depressive symptoms. Skeletal muscle is a potent producer of cytokines, and physical exercise has been suggested to alleviate symptoms of depression. In

The question of subgroups in eating disorders was addressed in this study. According to the DSM-IV manual, the two subtypes for anorexia nervosa are restricting and binge-eating/purging. For bulimia nervosa, the subtypes are purging and non-purging. An attempt was made here to examine alternative ways to create meaningful subgroups in the eating disordered patient group. A cluster analysis was per

OBJECTIVE: To determine whether different tests of the adrenocorticotropic hormone (ACTH) reserve are influenced by diabetic state and metabolic control in newly diagnosed type 1 diabetic patients. DESIGN AND METHODS: We evaluated the ACTH reserve in 10 patients with uncomplicated type 1 diabetes during periods of poor and improved metabolic control and in 10 healthy subjects. The ACTH-cortisol se

The concentration of homocysteine in plasma has been shown to be increased in renal failure, possibly contributing to the accelerated atherosclerosis observed in uraemic patients. The aim of the present study was to document the relationship between plasma total homocysteine (tHcy) concentrations and glomerular filtration rates (GFR) in highly selected patients, with renal function ranging from no

BACKGROUND: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer. METHODS: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnose

OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning b

Oscillations in plasma membrane potential play a central role in glucose-induced insulin secretion from pancreatic β-cells and related insulinoma cell lines. We have employed a novel fluorescent plasma membrane potential (ψp) indicator in combination with indicators of cytoplasmic free Ca2+ ([Ca2+]c), mitochondrial membrane potential (ψm), matrix ATP concentration and NAD(P)H fluorescence to inves

In vitro studies have shown that cystatin C (CysC) is neuroprotective. Here we demonstrate that CysC is neuroprotective in vivo, in a mouse model of the inherited neurodegenerative disorder, progressive myoclonic epilepsy type 1 (EPM1). Loss-of-function mutations in the cystatin B (CysB) gene, an intracellular cysteine protease inhibitor, lead to this human disease. A CysB-knockout (CysBKO) mouse

Sexuella övergrepp mot barn tillhör de mål som är allra svårast att hantera i svenska domstolar. Ofta består bevisningen i målet endast av barnets utsaga, vilket medför svåra bevisvärderingsproblem. Högsta domstolen har i NJA 2010 s. 671 fastslagit ett antal kriterier som kan vara behjälpliga vid bevisvärdering av muntliga utsagor. Vad som bland annat kan beaktas är om utsagan är lång, sammanhängaCases involving child sexual abuse are among the most complex cases for Swedish courts to handle. Evidence often only consists of the child’s statement, which complicates the process of evaluating the evidence. In order to facilitate the evaluation of oral statements the Supreme Court of Sweden established a number of different criteria in its ruling in NJA 2010 s. 671. The statements should for i

Det föreliggande arbetets övergripande syfte var att undersöka hur grammatiken beskrivs i läromedel i dag och vilka konsekvenser detta kan tänkas få för lärare och elever i Svenska 1 och Svenska 2 på gymnasiet. För att uppnå syftet delades arbetet upp i två separata metoder: Först utfördes en granskning av hur grammatiken beskrivs i olika läromedel, och sedan en intervjustudie där yrkesverksamma sThe present study’s overarching aim was to examine how grammar is described in textbooks today, and what consequences this might have for teachers and students in the courses Swedish 1 and Swedish 2, in upper-secondary education. To accomplish this, the study was divided into two separate methods: First, an examination of how grammar is described in different textbooks was conducted. After that, a

Computational Fluid Dynamics (CFD) is the study of fluid flows for the analysis of phenomena by scenarios simulated in a computer-based environment. One of the most well-known CFD simulation packages in the fire safety field is Fire Dynamic Simulator (FDS). The tasks of setting up an FDS input file can be time-consuming especially for complex building geometries. Building Information Modelling (BI

The aim of this research was to explore the consumer behavior of international students in the context of the choice for a higher education institution abroad in order to gain insights on their interactions with different online media communication channels during their decision journey. Previous research discussed the increased use of the internet during the application process for universities a

Optimal management of the commons to ensure sustainability relies on community management. Despite widespread knowledge of this, conventional wisdom is locked into how much the state should regulate the market. Free market ideology, defined as neoliberalism, promotes a culture of extreme competition and individualism which stand in contrast to the needed cultures of participation and inclusion for

Abstract - Svenska Denna kvalitativa uppsats syftar till att framföra subjektiva erfarenheter av att leva med Premenstruellt Dysforiskt Syndrom, PMDD på Engelska. Studiens fokus låg på att undersöka upplevelser av: (1) symptompåverkan på individerna med PMDS och deras arbetsplats; (2) påverkan på individens sociala liv och; (3) Vilket stöd föreslås och görs tillgängligt och hur stödet upplevs. Nit

The literary heroic ideal changed with the Great War, as the Victorian hero ideal was no longer plausible in a post-war world. The new ideal was pacifist and non-heroic but not everyone who had been through the Great War agreed that there was no heroicism. This essay discusses the development of the heroic ideal in the mid twentieth century in relation to the two brothers Boromir and Faramir in J.