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In the present work, oregano leaves (Origanum vulgare L.) are explored as natural source of nutraceuticals with antioxidant activity. To do this, subcritical water extraction (SWE), a new environmentally friendly technique, is employed as extraction procedure and HPLC coupled to DAD is used for the chemical characterization of the extracts. Moreover, the radical scavenging 1,1-diphenyl-2-picrylhyd

The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM

Climate policy objectives require zero emissions across all sectors including steelmaking. The fundamental process changes needed for reaching this target are yet relatively unexplored. In this paper, we propose and assess a potential design for a fossil-free steelmaking process based on direct reduction of iron ore with hydrogen. We show that hydrogen direct reduction steelmaking needs 3.48 MWh o

Purpose: Multidisciplinary team meetings (MDTMs) are an integral component of cancer care. Increasingly, virtual MDTMs are used to grant high-quality treatment recommendations across health-care regions, which expands and develops the local MDTM team to a regional or national expert network. We investigated health professionals’ experiences from national, virtual MDTMs for rare cancer with a focus

Sex pheromone biosynthesis in the Asian corn borer Ostrinia furnacalis was studied by topical application of deuterium labelled fatty acids to the pheromone gland. The incorporation of the labelled acids into pheromone components and precursors was determined by gas chromatography with flame ionization detection and mass spectrometry in the selected ion monitoring mode. The labelling experiments s

Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear transcriptional response commonly described as the mitochondrial unfolded protein response (UPRmt). Despite extensive studies of UPRmt pathways in animal and fungal systems, very little is known about h

BACKGROUND: Sarcopenia increases as renal function declines and is associated with higher morbidity and mortality. Myostatin is a negative regulator of muscle growth. Its expression in response to exercise is unclear. In this prespecified substudy of the Renal Exercise (RENEXC) trial, we investigated the effects of 12 months of exercise training on sarcopenia, muscle mass and plasma myostatin and

Observations during the Ice in Clouds Experiment-Tropical (ICE-T) field experiment show that the ice particles concentration in a developing deep convective clouds at the level of T = −15 °C reached about 500 L−1, that is, many orders higher than that of ice-nucleating particle. To simulate microphysics of these clouds, the 2-D Hebrew University Cloud model (HUCM) with spectral bin microphysics wa

We propose that CDCL SAT solver heuristics such as restarts and clause database management can be analysed by studying the resolution proofs produced by the solvers, and by trimming these proofs to extract the clauses actually used to reach the final conclusion. We find that for non-adaptive Luby restarts higher frequency makes both untrimmed and trimmed proofs smaller, while adaptive restarts bas

In relation to international obligations, under the Paris Climate Agreement and as a member state of the EU, Austria is expected to drastically cut carbon emissions over the coming years. In order to achieve this goal, measures to reduce emissions have to be taken in all sectors of the national economy. In this context it is interesting to note that to date it is widely unknown how much emissions

AbstractThe primary purpose of understanding disease etiology is to explain how a specific phenotype is determined by genotype. In pursue of this aim, exploring the diversity in DNA sequence variants that affect biomedical traits, especially those related to the onset and progression of genetically determined human disease. The human leukocyte antigens (HLA) are highly polymorphic cell surface pro

Asymmetrical flow FFF (AsFlFFF) is a member of field-flow fractionation (FFF) and can provide the separation of particles with size from nano to microscale based on their hydrodynamic diameters with smaller particles being eluted earlier than larger ones. For spheres, if the AsFlFFF conditions are well optimized, the FFF theory allows prediction of the elution time for a given diameter. Herein, we

Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and hear

The PICT method (pollution-induced community tolerance) can be used to assess whether changes in soil microbial response are due to heavy metal toxicity or not. Microbial community tolerance baseline levels can, however, also change due to variations in soil physicochemical properties. Thirty soil samples (0–20 cm), with geochemical baseline concentrations (GBCs) of heavy metals and from five diff

Laminated composites have so far received little attention as a potential material for gear drive applications. In the presented study, the thermomechanical performance of a newly developed type of epoxy impregnated, autoclave-cured carbon fibre-reinforced polymer gear—running in pair with a steel pinion—was analysed, using a combination of experimental and numerical approaches. The employed metho

Aggregation is a common phenomenon in the field of protein therapeutics and can lead to function loss or immunogenic patient responses. Two strategies are currently used to reduce aggregation: (1) finding a suitable formulation, which is labor-intensive and requires large protein quantities, or (2) engineering the protein, which requires extensive knowledge about the protein aggregation pathway. W

Objectives: Accurate and reliable diagnostics are crucial as histopathological type influ-ences selection of treatment in lung cancer. The aim of this study was to evaluate real-world accuracy and use of immunohistochemical (IHC) staining in lung cancer diagnostics. Materials and Methods: The diagnosis and used IHC stains for small specimens with lung cancer on follow-up resection were retrospecti

This paper presents an innovative study of the port system of Rome in Imperial times through the application of an integrated approach to both archaeological analysis and material evidence. Specifically, it seeks to provide a more complete contextualization and understanding of the port system of Rome by focusing on the exploration of the physical geography of the river Tiber and its transformatio

In the last years, the matter of the Romanization of Baetica has started to receive more attention, thus reactivating a topic largely assumed to be unproblematic in earlier approaches. Stemming from this interest, the present paper reviews theoretical and methodological approaches applied so far in the study of Roman rule in Baetica, before proposing new conceptualizations, research methods and in