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A genome-wide linkage analysis to identify quantitative trait loci (QTLs) for bone phenotypes was performed in an F-2 intercross of inbred spontaneously type 2 diabetic GK and normoglycemic F344 rats (108 males and 98 females). The aim of the study was to locate genome regions with candidate genes affecting trabecular and cortical bone and to investigate the effects of sex and reciprocal cross. pQ

A photochemistry study on nitrous oxide making use of site-selective excitation of terminal nitrogen, central nitrogen, and oxygen 1s-->3pi excitations is presented. The resonant Auger decay which takes place following excitation can lead to dissociation of the N(2)O(+) ion. To elucidate the nuclear dynamics, energy-resolved Auger electrons were detected in coincidence with the ionic dissociation

Laser-induced fluorescence is a technique for optical tissue characterisation. It has a real-time capability and as the excitation light and the fluorescence emission are transmitted through optical fibres the technique is compatible to various kinds of endoscopes for hollow organ investigation. The tissue fluorescence itself with the emission from the endogenous chromophores or enhanced with exog

Hexadecyltrimethylammonium bromide (C(16)TAB)-sodium perfluorooctanoate (C8FONa) and hexadecylpyridynium bromide (C16PyB)-(C8ONa catanionic semifluorinated mixtures have been studied by conductivity, dynamic light scattering (DLS), cryo-transmission electron microscopy (cryo-TEM) and polarizing microscopy. The regular Solution theory, applicable for a limited fluorinated molar ratio, does not pred

The structure and dynamics of a turbulent partially premixed methane/air flame in a conical burner were investigated using laser diagnostics and large-eddy simulations (LES). The flame structure inside the cone was charecterized in detail using LES based on a two-scalar flamelet model, with the mixture fraction for the mixing field and level-set G-function for the partially premixed flame front pr

Aims/hypothesis: Mutations in hepatic nuclear factor 1alpha cause a monogenic form of diabetes, maturity onset diabetes of the young type 3 (MODY3). Our aim was 1) to assess the uptake of genetic testing for MODY3 and to determine factors affecting it, and ( 2) to compare attitudes to predictive genetic testing between families with MODY3 and a previously studied group at risk of hereditary nonpol

Previous studies of gender differences in maximum oxygen uptake have come to different conclusions. Limited data exists where the determinants of maximum oxygen uptake have been evaluated in a comprehensive manner. Thus, we examined 248 children (140 boys and 108 girls), aged 7.9-11.1 years. Body composition was determined by dual-energy X-ray absorptiometry, measured variables were total body fat

Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level < 1 IU dL(-1). Studies to date, however, have not demonstrated a strong link between FVIII level and the bleeding rate.

The purpose of this thesis is to study the formation of opinions in issues related to the problem area of Christianity and culture of Public Theologian J A Eklund (1863-1945). The concept of Public Theologian refers to a theologian, who by participating in the cultural debate, strives to convince the public that Christianity is a superior theory of life even in modern society, and of Christianity’

1.. Implementation of the full spectra of screening tools to prevent the introduction of invasive species results in a need to evaluate the cost-efficiency of gathering the information needed to screen for these species. 2. We show how the Bayesian value of information approach can be used to derive the benefit of a screening model based on species traits, which in combination with the base rate o

The species richness of flower-visiting insects has declined in past decades, raising concerns that the ecosystem service they provide by pollinating crops and wild plants is threatened. The relative commonness of different species with shared ecological traits can play a pervasive role in determining ecosystem functioning, but information on changes in abundances of pollinators over time is lacki

Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) o

In traditional product development, several iterations are usually necessary to obtain a successful compromise between constraints emanating from engineering, manufacturing, and aesthetics. Moreover, this approach to product development is not well suited for true mass-customization, as the manufacturing company remains in control of all aspects of the shape of the product-to-be. In this article,

OBJECTIVES: The use of branched stent grafts for the treatment of thoracoabdominal aneurysms [TAAA] is increasing, but mating stent graft choice has not been studied. This study combined experience of five high volume centres to assess a preferred mating stent. METHODS: Data from five centres were retrospectively combined. Patients were included if they underwent stent graft for treatment of TAA

The dilution effect of N-2/CO2 on the laminar burning velocity of H-2-CO-O-2 mixtures was investigated. The dilution fraction of N-2 and CO2 in the unburned mixtures varied from 0% to 70% and 0%-50%, respectively, and H-2 content in H-2-CO fuels altered from 5% to 100%. All the studies were carried out at standard laboratory conditions (1 atm, 298 K) with equivalence ratio changing from 0.6 to 2.0

Using a combined experimental and theoretical approach, we show that a thin RhO2 oxide film forms on a Pt25Rh75(100) surface at elevated oxygen pressures and temperatures prior to the bulk oxidation. By the use of in situ surface x-ray diffraction under realistic CO oxidation reaction conditions, we show that the onset of the growth of thin RhO2 oxide film coincides with an increase in CO2 product

The new clusters [Ru-3(CO)(9)(mu-dppf){P(C4H3E)(3)}] (1, E = O; 2, E = S) have been prepared from the Me3NO-induced decarbonylation of [Ru-3(CO)(10)(mu-dppf)] in the presence of PFu(3) (E = O) and PTh3 (E = S), respectively. Upon thermolysis in benzene, the major products are the cyclometalated clusters [(mu-H) Ru-3(CO)(7)(mu-dppf){mu(3)-(C4H3E)(2)P(C4H2E)}] (3, E - O; 4, E - S). This thermolytic

Reaction of tri(2-furyl) phosphine (PFu(3)) with [Re-2(CO)(10) (n)(NCMe)(n)] (n = 1, 2) at 40 degrees C gave the substituted complexes [Re-2(CO)(10) (n)(PFu(3))(n)] (1 and 2), the phosphines occupying axial position in all cases. Heating [Re-2(CO)(10)] and PFu(3) in refluxing xylene also gives 1 and 2 together with four phosphido-bridged complexes; [Re-2(CO)(8) (n)(PFu(3))(n)(mu-PFu(2))(mu-H)] (n

Feedback in server systems has during last years gained much interest in order to fulfill still increasing demands on performance and optimization regarding, for example, quality of service (QoS) requirements. In this paper we investigate a feedback–based prediction scheme for controlling a single server queue. This control structure has the benefit over other previously suggested control structur