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Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks

Popular Abstract in Swedish Drygt en tiondel av Sveriges befolkning lider av hjärt-kärlsjukdom som också är den vanligaste dödsorsaken. Många av de akuta sjukdomstillstånden orsakas av att en bit inflammerad blodkärlsvävnad bryts loss från sitt fäste i något av de stora blodkärlen, färdas med blodet och täpper till blodflödet i mindre blodkärl. Detta leder till syrebrist och celldöd nedströms om dAbstract Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is associated with accumulation of cholesterol, which is an essential component of ce

A comparative study of digital human modelling simulation results and their outcomes in reality: A case study within manual assembly of automobiles

The objective of this study was to examine to what extent ergonomics simulations of manual assembly tasks correctly predict the real outcomes in the plants and if recommended measures originating from ergonomics simulations are taken into consideration. 155 ergonomics simulation cases were used in the study and all cases were performed by nine simulation engineers at Volvo Car Corporation in Gothe

Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.

Popular Abstract in Swedish Ett felaktigt protein som klumpar ihop sig i hjärnans blodkärl är orsaken till hjärnblödning och för tidig död hos unga islänningar. Sjukdomen är ärftlig och uppkommer på grund av en enda felaktig byggsten, orsakad av en mutation, i proteinet cystatin C. Det muterade proteinet bildar mikroskopiska proteinkedjor, fibriller, som klumpar ihop sig i bland annat hjärnans bloThe pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. This has hampered the devel

Risk factors and prevention among patients with hospital-acquired and pre-existing pressure ulcers in an acute care hospital

Aims and objectives. This study aimed to describe and identify risk factors associated with hospital-acquired pressure ulcers among adults in an acute care hospital compared with patients with pre-existing pressure ulcers present on admission. A further aim was to identify the preventive measures performed with both groups respectively. Background. Pressure ulcers occur most often in older and imm

Functionalized nanoparticles in aqueous surroundings probed by X-ray photoelectron spectroscopy

In this paper we present the first core-level photoelectron spectroscopic study of solid nanoparticles in liquid water. The particles are SiO2-based with an average diameter of 70 nm and functionalized with carboxylic groups. Despite that the sample is very dilute, we show that it is possible to obtain reasonable photoemission signal containing chemical information about both the ligands and the o

Evaluation of three principles for forklift steering: effects on physical workload

The aim of this study was to evaluate the consequences on the physical workload of new solutions in the forklift cab environment for the driver by quantifying the physical workload on the neck, shoulders, arms and wrists as an effect of steering systems. Twelve male subjects conducted identical test cycles with three types of steering: normal, tilted and miniature. The physical load on the drivers

Environmental and Economical Assessment of MSW Management in Europe: An Analysis between the Landfill and WTE Impacts

Every year two billion tons of MSW are produced globally. Due to the impact of solid waste and population growth, it is necessary to develop an integrated solid waste management plan. Such a plan, holistic in scope, would aim to minimize the negative impact of this material in the environment while being economically viable. The designation and terming of any one mode of waste treatment as superio

Neutron reflectometry on highly absorbing films and its application to (B4C)-B-10-based neutron detectors

Neutron reflectometry is a powerful tool used for studies of surfaces and interfaces. The absorption in the typical studied materials is neglected and this technique is limited only to the reflectivity measurement. For strongly absorbing nuclei, the absorption can be directly measured by using the neutron-induced fluorescence technique which exploits the prompt particle emission of absorbing isoto

Hydrolysis of Surfactants Containing Ester Bonds: Modulation of Reaction Kinetics and Important Aspects of Surfactant Self-Assembly

The effects of self-assembly on the hydrolysis kinetics of surfactants that contain ester bonds are discussed. A number of examples on how reaction rates and apparent reaction orders can be modulated by changes in the conditions, including an instance of apparent zero-order kinetics, are presented. Furthermore, it is shown that the examples on reaction kinetics display parallels and connections to

Design paradigmes and misunderstood technology: The case of older users

The stereotypes about older adults and the incomplete picture that emerges when such persons are described in terms of properties and a characteristic derived from ageing is one motivation for defining the status of older users. The other key motivation is that the elderly are just one user-group among others so that the perspective on how technology is used may or may not tell us something about

Machinability of Ductile Single-Phase Materials Used in Accelerator Components - A Study with Focus on Surface Integrity

The focus of this article has been to analyse the machinability, with focus on surface integrity, of oxygen-free copper (OFC) and niobium during turning operations. The results from machining OFC proved that all of the tools that was tested can be used to achieve a surface roughness below Ra = 0.8 µm with the correct cutting data. From the results when machining niobium it showed that only the cem

Perceived meaning in virtual reality architectural models

This explorative study investigated how the participants experienced a VR-presentation of an office building. Three office types (landscape, mixed and traditional) were presented in a between-subjects experimental design to employees at the Ericsson company in Sweden. The effects on the participants’ experience were measured using the Semantic Environ¬mental Scale (the SMB-scale, Küller 1975; 1991

Using design-of-experiments techniques for an efficient finite element study of the influence of changed parameters in design

All designs are marred by uncertainties and tolerances in dimen- sions, load levels etc. Traditionally, one has often over-dimensioned to take these uncertainties into account. The demand for optimized designs with high quality and reliability increases, which means that more sophisticated methods have been developed, see e.g. Lochner and Matar (1990). By describing the fluctuations in design para

Computational heat transfer in heat exchanger analysis and design

Rapid development of computer capacity and advances in numerical solution methods for the governing equations of fluid flow and heat transfer have enabled CFD (computational fluid dynamics) methods to gradually become useful tools in research and development, engineering design and analysis of heat transfer equipment. However, turbulence modelling still presents a problem as accurate and reliable

Strength at the extracellular matrix-muscle interface

Mechanical force is generated within skeletal muscle cells by contraction of specialized myofibrillar proteins. This paper explores how the contractile force generated at the sarcomeres within an individual muscle fiber is transferred through the connective tissue to move the bones. The initial key point for transfer of the contractile force is the muscle cell membrane (sarcolemma) where force is