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Ice core records are commonly used to infer information about past variability of CO2 fluxes. Because of processes involved in enclosing this air in ice, ice core records are a smoothed representation of the actual past atmospheric variations. As such, there is a limit to how much information ice core measurements can contain about flux variability on short timescales. With a numerical model of th
Airspace Dimension Assessment (AiDA) is a technique to assess lung morphology by measuring lung deposition of inhaled nanoparticles. Nanoparticles deposit in the lungs predominately by diffusion, and average diffusion distances, corresponding to effective airspace radii (rAiDA), can be inferred from measurements of particle recovery after varied breath holds. Also, particle recovery after a 0-s b
Objective: The significantly higher incidence rates of microscopic colitis (MC) in Denmark compared to Sweden remains unexplained. Methods: Consecutive patients with newly diagnosed MC in the neighbouring regions of Skåne in 2011–2015 and Zealand in 2010–2016 were prospectively identified. Data on large bowel endoscopies and biopsies rates were retrieved. Information on putative factors were obtai
Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is
The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has been lacking. Here, we used whole-genome genotyping of 1454 DLB cases and 1525 controls to assess copy number variability. We used 2 algorithms to confidently detect CNVs, performed a case-control association analysis, screened for candidat
Allogeneic hematopoietic cell transplantation can be curative in patients with hematological malignancies but carries a significant risk of graft-versus-host disease (GvHD). There are no standard treatments for steroid-refractory (SR) gastrointestinal (GI) acute GvHD (aGvHD). This multicenter, international, retrospective medical record review aimed to evaluate the off-label use of vedolizumab, a
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when w
Accurate diagnosis of histological type is important for therapy selection in lung cancer. Immunohistochemical (IHC) and histochemical stains are often used to complement morphology for definite diagnosis and are incorporated in the WHO classification. Our main aim was to compare different mucin stains and assess their value in relation to common IHC analyses in lung cancer diagnostics. Using tiss
Aims: To investigate to what extent socioeconomic differences in swimming abilities persist among children in the city of Malmö, Sweden, after a community-level swimming intervention programme in public primary schools. Methods: A compulsory swimming education programme was launched in 2014 in second grade (at age 8) in all public primary schools in Malmö, Sweden. Data for the present study on soc
Background: Mothers of preterm infants are at greater risk of symptoms of stress and anxiety compared to mothers of term infants. Aims: This study aimed to explore mothers’ experiences after coming home from the hospital with a moderately to late preterm infant. Methods: A qualitative and explorative method was used. Ten mothers who had given birth to a preterm baby with a gestational age between
Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these
Med hjälp av ett automatiserat mätsystem för partikelhalter i vatten har vattenkvaliteten vid Borensbergs vattenverk i Motala kommun undersökts under ett års tid med avseende på mikroskopiska partiklar i dricksvatten och råvatten. Antalet mikroskopiska partiklar registrerades som absoluta värden i realtid. I denna artikel diskuteras hur larmgränser skall definieras i praktiken för partikelhalter oDuring a one year long research project at Borensberg Waterworks, Motala, Sweden, water quality with respect to microscopic particle counts both in raw water and drinking water have been monitored by an online water quality monitoring system. Microscopic particle counts were documented with absolute values in real-time. In this paper, a discussion is introduced on how to analyze large data sets fr
Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer. Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods
Objectives: The aim of this study was to evaluate our experience with patients affected by ovarian carcinosarcoma. Patients and Methods: During a 16-year period, data on 13 patients with ovarian carcinosarcoma were collected. They were obtained from hospital charts and follow-up visits. Survival curves were estimated by the Kaplan-Meier method and compared using the log-rank test. All tests were t
Buildings are responsible for a third of global greenhouse gas emissions, with much of their life cycle impacts stemming from embodied impacts of building materials. Both at EU and Member State level, circular economy and resource efficiency policies are promoting production of lower-impact building materials with secondary material input. However, secondary material strategies do not result in ca
The migration of the great snipe Gallinago media was previously poorly known. Three tracks in 2010 suggested a remarkable migratory behaviour including long and fast overland non-stop flights. Here we present the migration pattern of Swedish male great snipes, based on 19 individuals tracked by light-level geolocators in four different years. About half of the birds made stopover(s) in northern Eu
Local adaptation is of fundamental interest to evolutionary biologists. Traditionally, local adaptation has been studied using reciprocal transplant experiments to quantify fitness differences between residents and immigrants in pairwise transplants between study populations. Previous studies have detected local adaptation in some cases, but others have shown lack of adaptation or even maladaptati
