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Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. Neuroblastoma is a childhood tumour that arises in the develop
A large Danish family has previously been reported in which autosomal dominant frontotemporal dementia (FTD) is genetically linked to chromosome 3 (FTD-3). A mutation was recently identified in the CHMP2B gene that is probably responsible for causing disease in this family. Because of its neuropathologic findings, FTD-3 was originally categorized as a subtype of frontotemporal lobar degeneration,
This paper suggests using a mixture of parametric and non-parametric methods to construct prediction regions in bivariate extreme-value problems. The non-parametric part of the technique is used to estimate the dependence function, or copula, and the parametric part is employed to estimate the marginal distributions. A bootstrap calibration argument is suggested for reducing coverage error. This c
The titration properties of a fatty acid solubilized in different types of micelles, cationic, anionic and nonionic, have been investigated experimentally and theoretically. The solution containing micelles, counterions, and added salt was treated as a dielectric continuum in the Monte Carlo simulations. The dielectric permittivity of the interior of the micelle can have a profound effect on the c
Tumor cells secreting IL-1 beta are invasive and metastatic, more than the parental line or control mock-transfected cells, and concomitantly induce in mice general immune suppression of T cell responses. Suppression strongly correlates with accumulation in the peripheral blood and spleen of CD11b(+)/Gr-1(+) immature myeloid cells and hematological alterations, such as splenomegaly, leukocytosis,
This study analysed the costs of median and ulnar nerve injuries in the forearm in humans and factors affecting such costs. The costs within the health-care sector and costs of lost production were calculated in 69 patients with an injury to the median and/or ulnar nerve in the forearm, usually caused by glass, a knife, or a razorblade. Factors associated with the variation in costs and outcome we
Context: Estrogens regulate bone mass by binding to the estrogen receptor (ER)-alpha as well as ER-beta. The specific ER -cofactor retinoblastoma-interacting zinc finger protein (RIZ)-1 enhances ER alpha function in the presence of estrogen. Objective: The objective of the study was to determine whether a RIZ P704 insertion (+)/ deletion (-) (indel) polymorphism modulates the impact of estradiol o
Background: Patients with many types of autoimmune diseases (AIDs) are at an increased risk of cancer, which may depend on underlying dysregulation of the immune system or treatment. We systematically analyzed myeloma risk and survival in patients diagnosed with 33 different AIDs. Methods: Data on patients with AIDs were retrieved from the Swedish Hospital Discharge Register and were linked to mye
Background: The survival of patients with locally advanced head and neck cancer is still poor, with 5-year survival rates of 24-35%. The identification of prognostic and predictive markers at the molecular and cellular level could make it possible to find new therapeutic targets and provide "taylor made" treatments. Established cell lines of human squamous cell carcinoma (HNSCC) are valuable model
In this paper we present surface electromyographic (EMG) data collected from 16 channels on five unimpaired subjects and one transradial amputee performing 12 individual finger movements and a rest class. EMG were processed using a traditional Time Domain feature-set and classifiers: a Linear Discriminant Analysis (LDA) a k-Nearest Neighbors (k-NN) and Support Vector Machine (SVM). Using continuou
Objective. Iron deficiency and anemia are being increasingly recognized as a complication of inflammatory bowel disease (IBD). The aim of this study was to observe, in a non-interventional way, how Swedish gastroenterologists adhere to guidelines in IBD outpatients treated with intravenous ferric carboxymaltose (FCM), and the result of treatment. Material and methods. Altogether 394 IBD patients (
This thesis addresses what students describe as their reasons for attending university, their descriptions of their encounters with the university milieu, and what significance they believe the existence of a local university such as Halmstad in south-west Sweden may have had in this. The empirical basis of the study consists of interviews with 58 students taking one of three courses at Halmstad U
Disturbances of interatrial conduction are linked to supraventricular arrhythmias. Previous studies have shown that these disturbances can be detected non-invasively as distinctive appearances of the orthogonal P wave using signal-averaged P-wave analysis (PSAECG). Orthogonal recordings (VCG) are however scarce in clinical practice for practical reasons. The aim of the presented study was to explo
To make good corporate strategy decisions, it is important to have reliable data. When making relocation decisions, it is important to know not only the manufacturing cost but also the production cost, cost model including the cost drivers of the whole production system. This paper presents two cost models of inbound logistics, one to estimate the costs in a current production system in detail and
Traumatic brain injury and bacterial meningitis may at a glance appear as two different disease entities. The host reaction, however, to both trauma and infection involves a strong inflammatory response, with the classical symptomology of rubor, tumor, calor, dolor et functio laesa. Tumor, swelling, will increase the volume within the closed cranial vault, and may thereby raise the intracranial pr
Several important observations emerge from this 2008 International Consultation "Bladder Cancer from Pathogenesis to Prevention". The following is a brief summary the issues that have been discussed in the articles from the meeting.
As Syria’s anti-authoritarian uprising and subsequent civil war have left the country in ruins, the need for understanding the nation’s complex political and cultural realities remains urgent. The second of a two-volume series, Syria from Reform to Revolt: Culture, Society, and Religion draws together closely observed, critical and historicized analyses, giving vital insights into Syrian society t
