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Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radio
Horse liver alcohol dehydrogenase and α-chymotrypsin were deposited on a porous support material, Celite. After equilibration at a well-defined water activity, the catalytic activity was measured with diisopropyl ether as reaction medium. The effects of the presence of polyols and simple saccharides in the preparations were investigated. The additives caused a considerable increase in the amount o
Background: In patients with arm or leg lymphedema, more fat has been found in the epifascial compartment of the edematous limb compared to the healthy limb. However, not much is known about subfascial fat accumulation in these patients. This study aims to investigate the intramuscular and intermuscular fat and muscle/water volume in lymphedema patients. The excess of intramuscular and intermus
Gender influences how researchers engage with the field (Porter & Schänzel, 2018). Departing from this proposition, this chapter offers reflections on gender from masculine vantages in the context of a qualitative research project investigating tourism enterprising in southern Sweden. Tourism enterprising is an important aspect of tourism development. Focusing on personal experiences associate
Surface heparinization of central venous catheters has earlier been shown to reduce the frequency of bacterial colonization and septicaemia. The present study was undertaken to investigate the benefit of surface heparinization of external ventricular drainage (EVD) catheters in relation to bacterial colonization, as measured by bacterial growth and examination by a 16S-rRNA PCR assay, of catheters
The objective of this article is to amalgamate previous results into a speculative synthesis that sheds light on the causes of secondary brain damage following either global/forebrain or focal ischemia. The hypothesis is based on the well-founded assumption that the pathophysiology of the brain damage incurred by global or forebrain ischemia is different from that of focal ischemia. In the former,
Feedbacks between climate warming, land surface aridity, and wildfire-derived aerosols represent a large source of uncertainty in future climate predictions. Here, long-term observations of aerosol optical depth, surface level aerosol loading, fire-area burned, and hydrologic simulations are used to show that regional-scale increases in aridity and resulting wildfires have significantly increased
The production of the ρ(770)0 meson has been measured at midrapidity (|y|
The aim of this study was to determine the association between childhood insulin-dependent diabetes mellitus (IDDM) and HLA-DR4 subtypes and to test in a population-based investigation whether the DR4 association has an effect independent to that of DQ. First, HLA genotyping identified DR4 in 337/425 (79%) patients and 148/367 (40%) controls (Odds Ratio 5.67; p < 0.01). Second, a total of 14 DR4 s
The transition to a circular economy requires the development of new business models. However, ‘circular’ businesses face a number of barriers when competing in the current ‘linear’ economy, and may require the support of public policies. Public procurement may be applied for this purpose, as it can support emerging markets for reconditioned and remanufactured products. Public procurement can also
In "Intentional action and side-effects in ordinary language” (2003), Joshua Knobe reported an asymmetry in test subjects’ responses to a question about intentionality: subjects are more likely to judge that a side effect of an agent’s intended action is intentional if they think the side effect is morally bad than if they think it is morally good. This result has been taken to suggest that the co
Introduction: This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma. Methods: In this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and
Capturing progression in students’ formal knowledge and employability skills is essential in higher education but evokes questions concerning how to assess and monitor progression. While methods for capturing students’ formal knowledge progression have traditionally been at the forefront, methods for capturing employability skills have been less researched within higher education. The aim of this
Accurate and efficient measurement techniques are needed for exposure assessment of 5G portable devices---which are expected to utilize frequencies beyond 6 GHz---with respect to the radio frequency electromagnetic field exposure limits. Above 6 GHz, these limits are expressed in terms of the incident power density, thus requiring that the electromagnetic fields need to be evaluated with high prec
Browning of surface waters, as a result of increasing dissolved organic carbon and iron concentrations, is a widespread phenomenon with implications to the structure and function of aquatic ecosystems. In this article, we provide an overview of the consequences of browning in relation to ecosystem services, outline what the underlying drivers and mechanisms of browning are, and specifically focus
