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Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell
Human genetics is a powerful tool for discovering causal mediators of human disease and physiology. Cardiovascular diseases with late onset in the lifecourse have historically not been considered genetic diseases, but in recent years the contribution of a heritable factor has been established. More importantly, over the last decade genome-wide association studies (GWASs) have identified many loci
Purpose: This paper aimed to present new insights into how Covid-19 has affected the European IPO market both in the short and long-term and how underlying factors can explain this phenomenon. Additionally, the paper's findings provide valuable insights into the effects of the pandemic on financial markets. It can help investors and policymakers to better understand the risks and opportunities
The Swedish Confederation of Trade Unions (LO) presented a new political report in 2015 with the purpose of renewing the wage policy of solidarity. The aim with a renewed wage policy is to create full employment instead of the present mass unemployment, to decrease the wage gap and to eliminate wagedrifts. The renewal may seem a bit strange, when the original policy (also called the Rehn-Meidner m
This study contributes with knowledge of effective strategies in the conversion towards a circular economy. Since construction and demolition waste (CDW) is one of the largest waste streams in the EU, there is a need to recycle the material. End of Waste criteria (EoW criteria), which specify when certain waste ceases to be waste, is a possible way of increasing the recycling rates. This study com
OBJECTIVES: To investigate the validity over time of the fingertip-to-floor test (FTF) and the straight leg raising test (SLR) using the Roland Morris Disability Questionnaire (RMDQ) and correlation coefficient (r), and to assess the predictive value of factors related to the change in RMDQ over 12 months using multivariate regression analysis. DESIGN: Longitudinal study. SETTING: Outpatient
Ensuring occupants' safety in building fires is one of the most important aspects for fire safety engineering. Many uncertainties are inevitably introduced when estimating the occupant safety level, due to the high complexity of fire dynamics and the human behaviour in fires. Safety factor methods are traditionally employed to deal with such uncertainties. This kind of methods is easy to apply but
Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall. On the other hand, under pathological process, apoB interacts with the arterial wall to initiate th
Aim: This study aims to describe how mothers spend the period of time between being diagnosed with a dead baby in utero and the induction of the delivery. Material and Methods: Data were collected using a web questionnaire. Five hundred and fifteen women who had experienced a stillbirth after the 22nd week of gestation answered the open question: 'What did you do between the diagnosis of the child
Some concerns still have not been resolved about the long-term safety of drug-eluting stents (DES) in patients with acute STEMI.
Earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor CCAAT/enhancer binding protein a at very high frequencies. Using this system, we performed a systematic analysis of whether during transdifferentiation the cells transiently reactivate progenitor-restricted genes or even retrodifferentiate. A transcriptome analysis of transdifferentiating cells sh
Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of the ubiquitin system has been linked to many diseases including skin cancer. The ubiquitin pathways activated among skin cancers are highly diverse and may refl
Sound is a fundamental element of our relationship to others and to the world. Current environmental, sociopolitical, cultural, and economic dimensions of our society can be captured and studied through sound. This article investigates ways of listening to future versions of our cities. Sound’s role is explored in the transformation of spaces and communities based on a dialectic between sound art,
Background: Cases of allergic contact dermatitis (ACD) caused by isobornyl acrylate (IBOA) in the Omnipod® insulin pump have previously been reported. Objectives: To present three cases of patients with ACD caused by a new allergen in the pump, and results from chemical analyses. Methods: Omnipod pumps from different batches were analysed by gas chromatography–mass spectrometry. Aimed testing, wit
The functioning of modern societies is highly dependent on flows, relying on timely deliveries of goods and services. Critical flows are those particularly important, e.g., electricity, food, and pharmaceuticals. Infrastructures upholding flows often transgress national borders, where a disruption can escalate into wide-spread crises. Continuity of critical flows is hence of outmost importance und
Purpose: This paper explores the idea of the prudent entrepreneurial self, through re-conceptualizing prudence into the domain of entrepreneurial education, to unite the two processes of becoming enterprising and entrepreneurial. It is argued that developing a capacity for prudence among graduates involves past, present and conjecture forms of knowledge that the authors find in the interplay betwe
The recent global financial crisis has once again shown how fragile the financial system is. This essay investigates the credit risk in the Nordic banking sector by measuring the probability of default of the six major Nordic banks. This is done by using the Merton (1974) model which utilizes stock prices as well as balance sheet data. The results are compared with an approach first suggested by H
BACKGROUND Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs. OBJECTIVE We aimed to develop a new prediction score for PPCs that uses both pre-operative and intra-operative data. DESIGN This is a secon
