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Purpose: Finasteride has been shown to reduce the incidence of prostate cancer. Yet the use of finasteride remains low, likely because of the risk of adverse effects. We sought to determine whether prostate-specific antigen (PSA) levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. Patients and Methods: Raw data from the Prostate
Fatal intoxications with opioids are known to be associated with an increased lung weight, as well as with brain and pulmonary edema and urinary retention. However, there is evidence to suggest that fatal intoxications with non-opioid substances are also associated with increased lung weight; however, the latter aspect has not been comprehensively analyzed. To determine to what extent opioid and n
PURPOSETo provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management.METHODSWe used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first
The Gaia spacecraft presents an unprecedented opportunity to reveal the population of long period (a > 1 au) exoplanets orbiting stars across the H-R diagram, including white dwarfs. White dwarf planetary systems have played an important role in the study of planetary compositions, from their unique ability to provide bulk elemental abundances of planetary material in their atmospheres. Yet, very
Is it truly the "end" of public space? This handbook presents evidence that the answer is "no". In cities in different parts of the world, people still use public space to pursue activities of their choice.The book is divided into seven sections. The first section presents three emerging types of public space. Each of the subsequent five sections focuses on a type of activity: recreation, commerce
Diabetes is an escalating health concern affecting approximately 152.6 million people globally in rural areas, with a significant rise in low- and middle-income countries where over 75% of affected adults live. These populations face unique challenges, including delayed diagnosis, limited access to specialized care, and economic hardships, leading to severe complications such as cardiovascular dis
Random indexing (RI) is a lightweight dimension reduction method, which is used, for example, to approximate vector semantic relationships in online natural language processing systems. Here we generalise RI to multidimensional arrays and therefore enable approximation of higher-order statistical relationships in data. The generalised method is a sparse implementation of random projections, which
The speedy advancement of digital technologies in the last decade has introduced new tools, workflows and stakeholders in diplomacy, creating significant information demands and a state of “digital stress”. To navigate these challenges, diplomats employ coping strategies that leverage their reflexivity and autonomy to manage demands, prioritize tasks, and mitigate overload. Beyond merely adapting
BACKGROUND: Existing conceptions of teaching quality assume that classroom interactions serve as the foundation for effective teaching. The resulting data necessitates analytical approaches capable of extracting the semantics of these interactions.AIM: This study investigates whether and to what extent lesson semantics provide insights into teaching quality (i.e., cognitive engagement, encourageme
This article is concerned with the estimation of aggregate relationships among a potentially large number of panel data variables in the presence of unobserved heterogeneity in the form of interactive effects, an empirically very relevant scenario that has not been considered before. One of our findings is that if the regressors load on the same set of latent factors as the dependent variable, whi
