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Background: Thalidomide has a chiral centre, and the racemate of (R)- and (S)-thalidomide was introduced as a sedative drug in the late 1950s. In 1961, it was withdrawn due to teratogenicity and neuropathy. There is now a growing clinical interest in thalidomide due to its unique anti-inflammatory and immunomodulatory effects. Objective: To critically review pharmacokinetic studies and briefly rev
The low-lying core-excited quintet states of Mg I have been studied experimentally and theoretically. On the basis of beam-foil spectroscopy, the energies of nearly all the quintet levels belonging to the 2p(5)3s3p2 and 2p(5)3s3p4s configurations have been established, while only 5F levels from the 2p(5)3s3p3d configuration could be identified. Multiconfigurational Hartree-Fock calculations, inclu
OBJECTIVE. To evaluate the recurrence of foot ulcers as well as the cumulative amputation and mortality rates in diabetic patients with previous foot ulcers. DESIGN. A prospective study of consecutively presenting diabetic patients admitted to the Department of Internal Medicine because of foot ulcer with a median follow-up of 4 years. SETTING. A multidisciplinary foot-care team. POPULATION. Five-
Purpose: The aim of the study was to evaluate the effect of perioperatively systemically administered betamethasone on nerve recovery (within or outside a confined space) after induced nerve crush injury. Materials and Methods: The sciatic nerve of 40 adult Wistar rats was crushed. In half of the animals, the injured nerve was entrapped in a silicone tube to simulate the environment of a closed sp
The complement system is old, yet it may still have something new to teach us. For many years, research has existed which shows that C3d, in addition to its established role as an adjuvant, could have an immunosuppressive activity. Being true, it suggests that a common mechanism may be used both by organisms and by their pathogens to prevent unwanted immune responses.
Vad innebär (och hur kan man bestämma) begreppet ”likhet”, att någonting ”liknar” sig självt eller något annat, att det därmed kan ”identifieras”, att det vidare kan ”för-likas” med ett begrepp och underställas dess identitet? Vad innebär (och hur kan man bestämma) begreppet ”skillnad”, att någon-ting aktivt eller passivt ”skiljer” sig från någonting annat, att ”skillnaden” utesluter och separerar
Essän handlar om dagens Libanon och berör de kraftmätningar och konfliktlinjer som skakar landet såväl inifrån som utifrån (regionala och globala intressen). Den är ett slags fortsättning på en artikel om Beiruts förhistoria som tidigare publicerats i Ord & Bild (nr 6/2004) – och kommer att utgöra en del av ett större arbete som publiceras i bokform i början av 2007 på Glänta förlag.
1 Recent studies have indicated that mast cells play an intermediate role in chemokine-induced neutrophil recruitment in vivo. 2 The aim of the present investigation was to determine the role of tumour necrosis factor-alpha (TNF-alpha) in neutrophil recruitment provoked by the CXC chemokine macrophage inflammatory protein-2 (MIP-2). For this purpose, we used mast cell- and TNF-alpha-deficient mice
Albumin concentration in a morning urine sample was analyzed in a cross-sectional study in 476 insulin-dependent diabetic patients. The following groups of patients were defined: A) normal urinary albumin (urine albumin less than 12.5 mg/L); B) high normal albuminuria (12.5-30 mg/L); C) microalbuminuria, ie, incipient nephropathy (31-299 mg/L); and D) clinical nephropathy (greater than or equal to
OBJECTIVES. The aim of the present study was to describe the 5-year incidence of retinopathy in type 1 diabetes mellitus and to characterize risk indicators for the development and progression of retinopathy. DESIGN. A cross-sectional study of type 1 diabetic patients taken care of at a medical department. SETTING. All type 1 diabetic patients attending the Department of Internal Medicine, Univers
Model systems of cross-linked polyelectrolyte gels were investigated by means of Monte Carlo simulations. The model contained a charged defect-free th ee-dimensional network of a diamond-like topology and explicit counterions. Pressure vs volume relations and chain extensions were determined and compared to those of the corresponding polyelectrolyte solution. The structure of the gel was character
It is shown that decision makers guided by Popperian epistemology will have a preference for transparency, even in situations where standard economic theory provides no rationale for such a preference. This provides a Popperian resolution of the Ellsberg paradox, and a rationale for suspicion in experiments as well as in economic life.
Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist i
If people believe that some property is true of all members of a class such as sofas, then they should also believe that the same property is true of all members of a conjunctively defined subset of that class such as uncomfortable handmade sofas. A series of experiments demonstrated a failure to observe this constraint, leading to what is termed the inverse conjunction fallacy. Not only did peopl
Excited-state dynamics and solvent-solute interactions of 1,1'-diethyl-2,2'-cyanine iodine (1122C) in alcoholic solutions are investigated using time-integrated three-pulse photon-echo spectroscopy. 1122C serves as a model compound for ultrafast photoinduced isomerizationa key process in the light reception of plants, bacteria, and human vision. The photoreaction in 1122C is interrogated in depend
