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Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4−8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patients w

The site–site Ornstein–Zernike equation with a simple mean spherical closure is used to study electrostatic interactions of proteins. Using a Debye–Hückel approximation for the correlation functions of the bulk electrolyte and a simple basis expansion for the protein–salt direct correlation functions, we obtain a very simple variational expression for the electrostatic component of the excess chem

Much of identity formation processes nowadays takes place online, indicating that intergroup differentiation may be found in online communities. This paper focuses on identity formation processes in an open online xenophobic, anti-immigrant, discussion forum. Open discussion forums provide an excellent opportunity to investigate open interactions that may reveal how identity is formed and how indi

A hybrid method of generalized transition matrix (GTM) and physical optics (PO) with synthetic basis functions (SBF) is proposed to analyze electromagnetic systems on electrically large platforms. Based on domain decomposition method (DDM), the proposed approach is to divide the whole problem into a GTM region and a PO region. The GTM algorithm can simulate antennas and scatterers accurately, and

This article provides an analysis on how disruptive innovation is spurred by the dynamics of digital and analogue networks in the sharing economy. The analysis builds on a free guided tour company in Copenhagen. Data is collected in a bottom-up reiterative process, drawing on theories on disruptive innovation and network theory. Between 2013 and 2016, one of the free tour companies in Copenhagen w

Behandlar premisserna för Nationalmuseums framtida verksamhet när det gäller renovering och nybyggnation på Blasieholmen.

Tobacco smoking is a major health and economic concern and is also known to have a significant negative effect on surgical outcomes. The benefits of a smoking cessation intervention prior to elective orthopaedic surgery have been evaluated previously. Our aim was to assess whether a smoking cessation program, initiated during the acute hospitalization period and carried out for six weeks, could re

This article examines the interpretation of biosignatures, the signs of life that could bedetected in outer space. In astrobiology biosignatures could be of various kinds, fossils, molecules, traces, artefacts, structures, electromagnetic waves, etc. The purpose of this article is to bring some semiotic order in this seemingly chaotic variation of signs. It turns out that the semiotic function of

ABSTRACT In a patient with advanced Hodgkin's disease (HD) associated with generalized pruritus, an unexpected relief of itching was found to be an early sign of spinal cord compression. Following irradiation of an extradural mass at the Th II level, itching recurred. Although the mechanisms bringing about itching in HD are unknown, the relief and recurrence of the symptom in our patient are in li

Cholecystectomy has been connected with an increase in colorectal, breast and reproductive system cancers. On 472 patients, 398 women and 74 men, cholecystectomized during the years 1951 to 1955, cancer incidence was investigated. Our results show an elevated risk of breast cancer in the female group (P = 0.016), but no significant increased risk in colorectal or gynaecologic cancer. The risk for

Purpose: This article hypothesizes that designing cancer therapies based on the organ specific toxicity of the normal tissue of the organ from which the tumors originated could be worthwhile. A prerequisite for successful therapy is that the individual can recover from damage done to the organ or cells.Results: Therapeutic examples are given for lymphoma, kidney cancer, melanoma and leukemia.Concl