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The placenta contains a large variety of metabolizing enzymes, among them UDP-glucuronosyltransferase (UGT). Several UGT2B isozymes have so far been detected in human placenta, but little is known on placental expression of UGT1A isozymes. The antiepileptic drug lamotrigine (LTG) is a UGT1A4-substrate, and its serum concentration falls by over 50% during pregnancy, leading to impaired seizure cont

This chapter examines the evolving landscape of craft and its implications for market exchanges, focusing on the embedded relationships between craft producers and consumers. Craft, characterized as an ideology of work resisting the dominance of industrialization and mass production, has experienced several waves of revival throughout history. While contemporary craft hints at alternative social a

To investigate multimodal signals in cat–human communication we recorded 36 cat–owner interactions in everyday situations that were judged by the owners for valence (negative, mixed or positive). We then coded the videos for behaviour using an ethogram including vocal, visual and tactile (multimodal) signals. Vocalisations were segmented and acoustic measures of duration and F0 obtained. In cats,

Social media platforms open up new methods of candidate messaging, voter contact, and data acquisition. Currently, affordances is a popular concept used to study the relationship between political campaigns and how they use social media platforms. Scholars argue that since platforms have different designs, they offer different affordances that affect how campaigns use social media. This chapter ev

The paper deals with language competence and language skills in the Swedish province on German soil, Swedish-Pomerania.

INTRODUCTION: Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms. Global coagulation assays, e.g., the thrombin generation test (thrombogram) have a potential to identify hemostatic defects that are not detected in specific

In recent IC designs, the risk of early failure due to electromigration wear-out has increased due to reduced feature dimensions. To give a warning of impending failure, wearout monitoring approaches have included delay measurement circuitry on-chip. Due to the high cost of delay measurement circuitry this paper presents a method to reduce the number of necessary measurement points. The proposed m

A scanning photoelectron microscope, utilizing a focused beam of monochromatized photons in the energy range from 15 to 150 eV, has been used to study the thermal desorption of oxide layers on Si(100). The instrument can provide high-resolution photoelectron spectra from selected parts of the surface as well as images showing the lateral distribution (on a micrometer scale) of elements in differen

BACKGROUND: Several major analyses have identified a consistent set of independent risk factors for cutaneous malignant melanoma (CMM). A few prognostic models have been presented but some are based on a limited number of patients and others are based on selected groups of patients referred to major institutions. No nationwide population-based prognostic instrument for survival of CMM has been pre

The National Environmental Objectives (NEOs) adopted by Swedish Parliament in 2001 and proclaimining that major environmental problems should be solved within a generation are often portrayed as good practice of a concrete yet visionary sustainability strategy. In this paper we summarize one and a half decade of the NEOs' experience for the international audience. The NEOs were based on an eclecti

This Editorial highlights a study published in the current issue of Journal of Neurochemistry by Dobson et al. (), investigating whether the immunomodulatory agent, laquinimod exerts an immunomodulatory effect on isolated Huntington´s disease monocytes. In Huntington´s disease (HD) a central immune activation is mirrored in the periphery by a low-grade immune response and monocytes isolated from H