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Cystatin C and the prion protein have been shown to form dimers via three-dimensional domain swapping, and this process has also been hypothesized to be involved in amyloidogenesis. Production of oligomers of other amyloidogenic proteins has been reported to precede fibril formation, suggesting oligomers as intermediates in fibrillogenesis. A variant of cystatin C, with a Leu(68)-> Gln substitutio
The world of Arda and the many stories set therein carry within them echoes of earlier tales, and even though it would be terribly reductive to discuss Tolkien’s work only in terms of its sources, knowledge of where the echoes come from contribute to our understanding and, perhaps more importantly, enjoyment of his world and stories. This is illustrated as much by the numerous university courses t
A plasma source free from characteristic emission lines is described, based on laser irradiation of a water jet in a helium atmosphere. Various key aspects of the laser interaction are presented along with practical characterization of the observed isotropic ~4–10 keV x-ray emissions, measurements of which indicate subpicosecond duration. Observations are consistent with a vacuum heating plasma me
Simulations with the EGSnrc code package of an orthovoltage x-ray machine have been performed. The BEAMnrc code was used to transport electrons, produce x-ray photons in the target and transport of these through the treatment machine down to the exit level of the applicator. Further transport in water or CT based phantoms was facilitated by the DOSXYZnrc code. Phase space files were scored with BE
The shape and features of a typical abbey church of the Birgittine Order are studied, based on the stipulations laid down by St. Birgitta of Sweden herself. The architecture is interpreted as paradigmatic of the kind of spiritual reform that St. Birgitta aimed at.
OBJECTIVES: To assess outcomes (wound healing, amputation and mortality) after vacuum assisted closure (VAC((R))) therapy of peri-vascular surgical site infections in the groin after arterial surgery. DESIGN: Retrospective study. MATERIALS: Thirty-three groins received VAC((R)) therapy between August 2004 and December 2006 at Vascular Centre, Malmö University Hospital. METHODS: Following surgical
A common mammalian defense mechanism employed to prevent systemic dissemination of invasive bacteria involves occlusion of local microvasculature and encapsulation of bacteria within fibrin networks. Acquisition of plasmin activity at the bacterial cell surface circumvents this defense mechanism, allowing invasive disease initiation. To facilitate this process, S. pyogenes secretes streptokinase,
Preclinical studies support an anticancer effect of statin drugs, yet epidemiologic evidence remains inconsistent regarding their role in breast cancer primary prevention. Here, we report an updated analysis of the association between statin use and breast cancer incidence in the Nurses' Health Study (NHS) cohort. Postmenopausal NHS participants without a cancer history were followed from 2000 unt
The length of stay in hospital following total knee replacement is markedly shortened due to fast-track programmes. Patients have to be responsible for their recovery at a very early stage. The aim of this study was to investigate the prevalence of physical health problems and the level of exercising in the early recovery period after discharge from hospital following total knee replacement.
OBJECTIVES: The primary objective of this study was to examine how a group of Swedish teachers rate aspects of their working environment that can be presumed to have an impact on vocal behavior and voice problems. The secondary objective was to explore the prevalence of voice problems in Swedish teachers. METHOD: Questionnaires were distributed to the teachers of 23 randomized schools. Teaching st
AIM: To investigate the association between political trust (an aspect of institutional trust) and self-rated health, taking generalized (horizontal) trust in other people into account. METHODS: The 2004 public health survey in Skåne is a cross-sectional postal questionnaire study answered by 27,963 respondents aged 18-80 years, yielding a 59% response rate. A logistic regression model was used to
A passive system is one that cannot produce energy, a property that naturally poses constraints on the system. A system in convolution form is fully described by its transfer function, and the class of Herglotz functions, holomorphic functions mapping the open upper half plane to the closed upper half plane, is closely related to the transfer functions of passive systems. Following a well-known re
The aim of this population-based study was to (1) describe living conditions and actual health care utilization among 85 year olds; (2) determine factors that affect hospital admissions in this age. The study was conducted on 85-year-old residents in Linköping municipality, Sweden. The data collected included medical records, health care utilization during the preceding 12 months and a postal ques
The article provides an overview of ongoing research and key characteristics of Cognitive Semiotics, an emerging field dedicated to the transdiciplinary study of meaning, involving above all researchers from semiotics, linguistics, developmental and comparative psychology and philosophy. The combination of the following features distinguishes it from other synthetic approaches: (a) integration of
To explore the experiences over time of using mobility devices (MDs) among very old women in the context of everyday life in Latvia.
A modified Delphi method was used to determine thresholds for Minimum Data Set quality indicators for Icelandic nursing homes. The thresholds were then applied to quality outcomes in Icelandic nursing homes for the year 2009. The thresholds indicate areas of good or poor care and can be used for planning services. Icelandic nursing homes seem to be doing best in incontinence and nutritional care.
