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Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptor
The ideological (re)construction of the position of Swedish in Finland is examined as it took shape during a major year-long debate about the role of Swedish in Finnish education. Data were collected through archival research of the leading national newspapers in the two official languages of Finland: Helsingin Sanomat (Finnish) and Hufvudstadsbladet (Swedish). Circulating and intersecting discour
A focus on constructing regional advantage requires an 'unpacking' of what makes territorial agglomerations important for innovation and competitiveness by disclosing and revealing the contingencies, particularities and specificities of the various contexts and environments where knowledge creation, innovation and entrepreneurship take place. In order to achieve more effective regional innovation
The objective of this study was to examine the relationship between self-reported and professionally assessed functional limitations in community-dwelling very old individuals. In total, 306 single-living adults aged 81-90 years were included in this cross-sectional study. The main outcome measure was the presence and absence of self-reported and professionally assessed functional limitations. A s
The European Surgical Outcomes Study (EuSOS) revealed large variations in outcomes among countries. In-hospital mortality and ICU admission rates in Sweden were low, going against the assumption that access to ICU improves outcome. Long-term mortality was not reported in EuSOS and is generally poorly described in the current literature.
Maturity models are widely used in process improvement. The users of a maturity model should be confident that the weak points of the assessed processes can be found, and that the most valuable changes are introduced. Therefore, the evaluation of maturity models is an important activity. In this paper, a mapping study of the literature on the evaluation of maturity models is presented. Two databas
The aim of this research was to analyse variation in body image perception and satisfaction by age, sex and nutritional status in an adult sample from the Basque Country, Spain. A case-control study was performed for 227 women and 178 men aged 18-70 years. Stunkard's silhouettes were used to evaluate Current Body Image (CBI) and Ideal Body Image (IBI), as well as dissatisfaction and inconsistency
This article examines the impact of prognostic factors, adjuvant therapy, and randomized trials on the overall survival of patients with endometrial cancer. The potential role of radiation therapy as an adjuvant therapy, as well as the role of lymph node dissection, in the treatment of endometrial carcinomas is reviewed.
Purpose: The purpose of this study is to explore warehouse configuration in omni-channel retailing. Design/methodology/approach: A multiple case study is conducted with six large omni-channel retailers from three different sectors. Findings: The study shows an increase in the number, variation and frequency of flows passing through omni-channel warehouses. Along with an increased variety of stock
This study analyzes transformations in institutions of affordable housing production connected to neoliberalization, which have impacted affordability rates and income gaps in Copenhagen and Istanbul. Also, different types of affordable housing began to develop, such as modular housing of Almenbolig+ in Copenhagen and housing for very low-income people in Istanbul. Increased affordability rates ar
FELs are well known for generating highly coherent light with excellent brilliance. In order to improve FEL coherence we have to follow how coherence evolves along the undulator and determine the factors that influence it the most. This paper presents qualitative coherence features that shine new light on the importance of coherence studies in the design of an FEL. By simulating and then analyzing
The kinetics of the buildup and decay of photoinduced birefringence was examined in a series of host-guest systems: azobenzene-containing crown ethers, differing in the size of the crowns, dissolved in a poly (methyl methacrylate) matrix. In all samples, the kinetics of the buildup of the birefringence was reasonably described by a sum of two exponential functions, the time constants being inverse
Objective: People who suffer from psychiatric illness have a more than doubled lifetime risk of acquiring an alcohol or drug use disorder. Furthermore, hazardous substance use impairs treatment outcomes and protracts the duration of illness among people with mental disorders. The aim of this study was to investigate substance use among people with psychiatric disabilities receiving municipality-ba
This case study investigates the implementation of a free-choice market system in community mental health services using the example of day centres for people with psychiatric disabilities. It was conducted in a major city that was about to implement a free-choice market system due to a new legislation that made it feasible. Eighteen semi-structured interviews were conducted. Agents situated in di
Purpose: Data on the incidence of colorectal cancer (CRC) is conflicting, and it is unknown if the incidence is constant, declining, or increasing. Proximal colon cancer is considered to be more common among older individuals, but recent data have shown that rectal cancer and distal colon cancer have been increasing in the younger population. The aim of this study was to determine the trends regar
Purpose - Distribution arrangements are becoming increasingly complex and dynamic in business as well as in consumer markets. The purpose of the present paper is to explore and discuss the theoretical frameworks available to interpret these distribution arrangements, to uncover how they are interrelated and to suggest extensions. Design/methodology/approach - A survey of extant research is underta
