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In this paper we derive the finite-sample distribution of the estimated weights of the tangency portfolio when both the population and the sample covariance matrices are singular. These results are used in the derivation of a statistical test on the weights of the tangency portfolio where the distribution of the test statistic is obtained under both the null and alternative hypotheses. Moreover, w
Several earlier studies have assessed survival in breast cancer based on familial risk of this disease. The results have been conflicting and suggest that the risk and prognostic factors of cancer are largely distinct. As a novel concept, we searched for familial clustering of survival, i.e., concordance of survival among family members. We used the nation-wide Swedish Family-Cancer Database to es
We report on the observation of the solvation shell rearrangement after abstraction of the electron from aqueous I - in a laser pump/X-ray probe experiment by recording the X-ray absorption L 1 - and L 3 -edge
Optical spectroscopy of Tm3+-doped 59H3BO 3-20ZnO-20LiF-1Tm2O3 glass is presented. From the measured absorption spectra, radiative parameters were determined using the Judd-Ofelt (JO) theory. Excitation in the range of 750-800 nm resulted in a frequency up-converted emission at 453 nm (1D2 → 3F4). Excitation spectra and intensity dependence of the up-converted fluorescence have been investigated a
The evolution of epidemiological burden in Imperial Russia and, consecutively, the Union of Soviet Socialist Republics (USSR), took place mostly over the duration of the past century [...].
Purpose – The purpose of this paper is to explore, describe and categorise practices of managing product returns empirically in internet retailing.Design/methodology/approach – A multiple case study was conducted involving 12 e-commerce firms and 4 logistics service providers. An integrative data collection approach of semi-structured interviews, documentation and observations was used to gain com
Given the increasingly polarized debates in many modern democracies over migration and integration, the behaviour of members of parliament (MPs) with a migrant background has important implications for patterns of representation. Drawing on role congruity theory, we hypothesize that MPs with a migrant background deliver more legislative speeches in debates that are of interest for citizens with a
Nuclear morphometry was performed on the diagnostic biopsy in 65 cases of non-mucinous ovarian carcinoma (FIGO stage IIB-IV) and its prognostic value regarding patient survival after the second-look operation was compared to that of morphology and clinical observations. In a univariate Cox survival analysis four morphometric factors were found to be significant predictors of survival (the standard
The purpose was to examine the association between exercise during pregnancy and intelligence score in offspring. We analyzed data from 4008 women from the Aarhus Birth Cohort, Aarhus University Hospital, Denmark, recruited during pregnancy from July 1989 to November 1991 and their sons who were registered at conscription at 17-20 years of age. The women gave information by self-administered quest
Background: Prophylactic central neck dissection in patients with papillary thyroid carcinoma is controversial. Sentinel node biopsy might be an adjunct to optimize surgical treatment for these patients. Earlier studies reported inconsistent detection rates and diagnostic value of this technique, and the role of sentinel lymph node biopsy in thyroid cancer needs to be established. Patients and met
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we h
Objectives: Functional gastrointestinal (GI) symptoms, such as IBS (irritable bowel syndrome), have been suggested to be associated with autonomic neuropathy. We therefore examined associations between hemodynamic indices of autonomic control, functional GI symptoms and stress in a population-based cohort.Methods and materials: The study included 2094 participants of the Malmö Offspring Study (mea
Neutrophil extracellular traps (NETs) are web-like antimicrobial structures consisting of DNA and granule derived antimicrobial proteins. Immunofluorescence microscopy and image-based quantification methods remain important tools to quantitate neutrophil extracellular trap formation. However, there are key limitations to the immunofluorescence-based methods that are currently available for quantif
Energy is an important resource in society and we often depend on energy in our everyday life. Energy-related emissions constitute at the same time a major environmental load, and we need to use energy more efficiently. To develop sustainable energy systems users need to transform their behaviour and start reflecting on their energy use. The aim of this paper is to discuss different methods to vis
A common assumption in product value literature is that authenticity is what contemporary consumers value the most. However, as this paper illustrates, the meaning of authenticity is unclear, and the term appears foreign to product development practitioners. The purpose of this paper is to explore in what ways product development professionals talk about product value in general and how this relat
Respiratory diseases, such as chronic obstructive pulmonary disease and pulmonary fibrosis, result in severely impaired quality of life and impose significant burdens on healthcare systems worldwide. Current disease management involves pharmacologic interventions, oxygen administration, reduction of infections, and lung transplantation in advanced disease stages. An increasing understanding of mec
PurposeThe purpose of this paper is to establish measurable factors that can be used as early indicators of which neighborhoods are most likely to undergo a process of gentrification in a reasonably near future.Design/methodology/approachUsing 1990 data on key demographic variables for 128 neighborhoods in Stockholm, Sweden a model that allows both for testing of spatial clustering and for spatial
Background: We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV). Objectives: To increase detection of HPV among self-samples. Study design: We used a pre-heating step at 90 °C for 1 h on our previously AHPV-negative self-
