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In this study, the signal cascade transducing carbachol stimulation into c-fos expression in SH-SY5Y neuroblastoma cells was investigated. 1,2-Diacylglycerol formation and c-fos expression were mediated via stimulation of muscarinic M1 receptors and the first 5 min of receptor stimulation were critical for these events. Application of 1,2-dioctanoylglycerol induced c-fos expression and this, as we
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced
Background: Some, but not all, reports suggest that patients with Gaucher disease are at increased risk of developing malignancies, particularly hematopoietic tumors. The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals. Methods: Among 832 294 African American and 3 668 983 white male veterans w
1. In intensively farmed agricultural landscapes, many species are confined to very small uncultivated areas such as field margins. However, it has been suggested that these small habitat elements cannot support viable populations of all the species observed there. Instead, species richness and abundance in these small habitat fragments may, at least partly, be dependent on dispersal from larger s
OBJECTIVE: To present validity data for the Work Experience Measurement Scale (WEMS), an instrument measuring multifaceted work experience from a salutogenic health resource perspective as a contrast to the more common pathogenic risk perspective, by exploring WEMS relationship to established measurements that are positively related to health and work. A salutogenic perspective focuses on finding
PURPOSE: To describe a heretofore unreported complication involving the Zenith Low Profile (LP) stent-graft. CASE REPORT: Two men, aged 75 and 67 years, respectively, underwent abdominal aortic aneurysm repair with a Zenith LP device. At 4 and 3 years, respectively, computed tomography angiography revealed separation of the proximal fixation stent from the stent-graft. In the first patient, ther
We present a calculation of the finite volume corrections to meson masses and decay constants in three flavour Partially Quenched Chiral Perturbation Theory ( PQChPT) through two-loop order in the chiral expansion for the flavour-charged ( or off-diagonal) pseudoscalar mesons. The analytical results are obtained for three sea quark flavours with one, two or three different masses. We reproduce the
Solar energy conversion into electricity by photovoltaic modules is now a mature technology. We discuss the need for materials and device developments using conventional silicon and other materials, pointing to the need to use scalable materials and to reduce the energy payback time. Storage of solar energy can be achieved using the energy of light to produce a fuel. We discuss how this can be ach
Aromatic ring flips of Phe and Tyr residues are a hallmark of protein dynamics with a long history in molecular biophysics. Ring flips lead to symmetric exchange of nuclei between sites with distinct magnetic environments, which can be probed by NMR spectroscopy. Current knowledge of ring-flip rates originates from rare cases in which the chemical shift difference between the two sites is sufficie
The objective of this prospective cohort study was to describe real-life use of lipid-lowering drugs and low-density lipoprotein cholesterol (LDL-C) target-attainment rates 1 year after acute myocardial infarction (AMI). LDL-C was recorded at hospital admission for AMI and at follow-up at 2 and 12 months after AMI in 17,236 patients in the Swedish heart registry, SWEDEHEART, from 2004 through 2009
Background: A high prevalence of sickness absence in many countries, at a substantial societal cost, underlines the importance to understand its determining mechanisms. This study focuses on the link between relative deprivation and the probability of sickness absence. Methods: 184,000 men and women in Sweden were followed between 1982 and 2001. The sample consists of working individuals between t
Most of the observed extrasolar planets are found on tight and often eccentric orbits. The high eccentricities are not easily explained by planet-formation models, which predict that planets should be on rather circular orbits. Here we explore whether fly-bys involving planetary systems with properties similar to those of the gas giants in the Solar system can produce planets with properties simil
Adsorption of thymine on a defined Cu(110) surface was studied using reflection-absorption infrared spectroscopy (RAIRS), temperature programmed desorption (TPD), and scanning tunnelling microscopy (STM). In addition, density functional theory (DFT) calculations were undertaken in order to further understand the energetics of adsorption and self-assembly. The combination of RAIRS, TPD, and DFT res
BACKGROUND: Limited data exists of tracking and changes in accelerometer measured physical activity in children. METHODS: Physical activity was assessed by accelerometers for four days in 167 children (boys n=90, girls n=77), aged 9.8±0.6 years. Follow-up measurement was made 2.0±0.1 yrs later (range 1.9-2.1 yrs). General physical activity (GPA) was defined as mean count/minute. Minutes of inact
The objective of this study was to evaluate the protective effects of a new device for reducing perineal tears during vaginal childbirth.
Santiago was one of the first cities outside the OECD to implement a tradable permit program to control air pollution. This article looks closely at the program's performance over the past 10 years, stressing its similarities and discrepancies with trading programs implemented in developed countries and analyzing how it has reacted to regulatory adjustments and market shocks. Studying Santiago's e
