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The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies3–7, large-scale genome-wide association studies (GWAS) of fasting BCF8,9 or functional islet studies on T2D risk variants10–14. Nonetheless, GWAS focused on BCF traits derived from oral
Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Met
BackgroundPrevious studies have suggested that Toxoplasma gondii (T. gondii) infection might be associated with fatty liver disease. However, the relationship between non-alcoholic fatty liver disease (NAFLD) and T. gondii infection has not been investigated in a large population. We aimed to study the relationship between those two diseases using a population-based dataset from the United States.
The real antibiotic industrial wastewater with the characteristics of complex compositions, biological toxic, and degradation-resistant, is still biologically toxic to the ecosystem and human health even if the discharge standards have been met after treatment by traditional methods. Therefore, the biological harmless treatment of real antibiotic industrial wastewater is a valuable and meaningful
α-Synuclein aggregates constitute the pathology of Lewy body (LB) disease. Little is known about the effects of LB pathology in preclinical (presymptomatic) individuals, either as isolated pathology or coexisting with Alzheimer's disease (AD) pathology (β-amyloid (Aβ) and tau). We examined the effects of LB pathology using a cerebrospinal fluid α-synuclein-seed amplification assay in 1,182 cogniti
Industrial fermentation of lignocellulosic hydrolysates to ethanol requires microorganisms able to utilise a broad range of carbon sources and generate ethanol at high yield and productivity. D. bruxellensis has recently been reported to contaminate commercial ethanol processes, where it competes with Saccharomyces cerevisiae [4, 26]. In this work Brettanomyces/Dekkera yeasts were studied to explo
Forests are pivotal for biodiversity, food webs, and human economies, and as carbon sinks their climate change mitigation potential is undisputed. However, whether trees continue to efficiently accumulate biomass at an increasing rate with age, how growth trajectories respond to climate change, and vary with latitude at species range margins is under debate. Here, we combine tree-ring data with bi
BACKGROUND: Structural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear. Oxidative stress and redox dysregulation have been proposed to play a role in the pathophysiology of several psychiatric conditions, but their anatomical and functional con
OBJECTIVE:: To evaluate effect on comorbid disease and weight loss 5 years after Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity in a large nationwide cohort. BACKGROUND:: The number patients having surgical procedures to treat obesity and obesity-related disease are increasing. Yet, population-based, long-term outcome studies are few. METHODS:: Data on 26,119 individuals [75.8% women,
We have investigated whether alchemical free-energy perturbation calculations of relative binding energies can be sped up by simulating a truncated protein. Previous studies with spherical nonperiodic systems showed that the number of simulated atoms could be reduced by a factor of 26 without affecting the calculated binding free energies by more than 0.5 kJ/mol on average (Genheden, S.; Ryde, U.
Novel soil remediation equipment based on electro-kinetic geosynthetics (EKG) was developed for in situ isolation of metals from paddy soil. Two mutually independent field plot experiments A and B (with and without electric current applied) were conducted. After saturation using ferric chloride (FeCl3) and calcium chloride (CaCl2), soil water drainage capacity, soil cadmium (Cd) removal performanc
Malunion after a distal radius fracture can be treated with an osteotomy of the distal radius. Autologous iliac crest bone graft is often used to fill the gap, but the procedure is associated with donor site morbidity. In this study a novel fast resorbing biphasic bone substitute consisting of a mixture of calcium sulphate and calcium phosphate is used (Cerament BoneSupport AB, Sweden). Fifteen co
AIM: To evaluate long-term endocrine and exocrine pancreatic function, quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis (SAP). METHODS: Patients prospectively included in 2001-2005 were followed-up after 42 (36-53) mo. Pancreatic function was evaluated with laboratory tests, the oral glucose tolerance test (OGTT), fecal elastase-1 and a questionnair
Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic
Checklist and Word manual for theses PREPERATION | FORMATING | TABELS | INSERT PICTURES | ILLUSTRATIONS 2 CHECKLIST AND WORD MANUAL FOR THESES | 2020 Table of contents Timetable and preparation ......................................................................4 Before you start......................................................................................4 Help with composition.........
https://www.intramed.lu.se/en/sites/intramed.lu.se.en/files/2023-06/2020%20folder%20avh%20engelsk%20ny.pdf - 2026-07-10
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children David Endesfelder,1 Wolfgang zu Castell,1,2 Ezio Bonifacio,3,4 Marian Rewers,5 William A. Hagopian,6 Jin‐Xiong She,7 Åke Lernmark,8 Jorma Toppari,9,10 Kendra Vehik,11 Alistair J.K. Williams,12 Liping Yu,5 Beena Akolkar,13 Jeffrey P. Krischer,11 Anette-G. Ziegler,4,14,15,16 and Peter Achenbach
03272025_679_173_MP58_Gesualdo_Cont Clin Trials Comm_2025.pdf Structures and strategies for retaining an international pediatric cohort from birth: Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) study Patricia Gesualdo a,1,* , Jessica Melin b,1 , Rachel Karban a , Claire Crouch c , Michael Killian c , Diane Hopkins d , Annika Adamsson e , Joanna Stock f , Suzanne Benn
https://www.teddy.lu.se/sites/teddy.lu.se/files/2025-05/173_MP58_Gesualdo_Cont%20Clin%20Trials%20Comm_2025.pdf - 2026-07-10
November 2024 What does it take to implement a complementary currency in a community, and how does it reshape social, technical, and economic dynamics? Juan Ocampo, a PhD graduate from Lund University’s School of Economics and Management (LUSEM) and the Agenda 2030 Graduate School, has spent five years investigating these questions.In his dissertation, Organizing Money: The process of implementing
https://www.agenda2030graduateschool.lu.se/activities/news-2025/news-and-events-2024 - 2026-07-09
Patient weight [kg] = 75; Nucleus = "H1"; SmartSelect = "no"; clinical modes = "SENSE_HEAD_7TX_32"; Coil 1 = "Sense-Head-7TX"; Channels = (16) "yes", (16) "no"; connection = "ConnA"; Coil 2 = "Sense-Head-7TX"; Channels = (16) "yes", (16) "no"; connection = "ConnB"; Coil 3 = "None"; Uniformity = "CLEAR"; FOV FH (mm) = 230.488358; AP (mm) = 230.488358; RL (mm) = 168; Voxel size FH (mm) = 0.699999988
https://www.lbic.lu.se/sites/lbic.lu.se/files/3d_flair_0_7sag.txt - 2026-07-10
Dnr STYR 2021/1324 2021-05-20 Lund University Centre for Sustainability Studies 2/3 3/3 Hållbarhetsvetenskap, 10 högskolepoäng MESS33 LITERATURE LIST Sustainability Science, 10 credits MESS33 litteraturlista fastställd av LUCSUS styrelse den 20 maj 2021. Course literature 1. Bergmann, M., Schäpke, N., Marg, O. et al. Transdisciplinary sustainability research in real-world labs: success factors and
https://www.lumes.lu.se/sites/lumes.lu.se/files/2021-05/MESS33%20Sustainability%20Science%20May%202021.docx - 2026-07-10
