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Environmental and process control applications have needs for sensors that operate continuously or repeatedly, making them applicable to batch measurement and flowing product stream measurement. Additionally, for lactose monitoring in dairy-processing plants, the sensors must have sufficient flexibility to handle a wide range of substrate concentration and be resilient to withstand wide pH excursi
Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated prot
Popular Abstract in Swedish Vid genterapi för man in nya gener i en individs celler. Detta kan göras med hjälp av modifierade virus. Dessa virus kan föra in den nya genen, den såkallade transgenen, in i värdcellen men inte bilda nya viruspartiklar. I många fall är det viktigt att begränsa i vilka celler som transgenen uttrycks, då det producerade proteinet kan ge bieffekter i andra celltyper. Det Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects
Two monoclonal antibodies (mAb) CB268 and CII-C1 to type 11 collagen (CII) react with precisely the same conformational epitope constituted by the residues ARGLT on the three chains of the CII triple helix. The antibodies share structural similarity, with most differences in the complementarity determining region 3 of the heavy chain (HCDR3). The fine reactivity of these mAbs was investigated by s
Vascular smooth muscle cells (VSMCs) in the intact vascular wall are differentiated for contraction, whereas the response to vascular injury involves transition towards a synthetic phenotype, with increased tendency for proliferation. Platelet-derived growth factor (PDGF) is thought to be important for this process. We investigated expression and functional coupling of PDGF receptors (PDGFRs) alph
The variable region 1 to 3 (V1-V3) of the HIV-1 envelope plays an important role in coreceptor usage. Early in infection HIV- 1 is using CCR5 as coreceptor to enter target cells (R5 viruses) whereas viruses using CXCR4 as coreceptor (X4 viruses) may appear later in infection. This broadening or switch in coreceptor usage is associated with progression to AIDS. In my thesis work, we have compared t
Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for
Objectives: Polyamines are organic polycations playing an essential role in cell proliferation and differentiation, as well as in cell contractility, migration and apoptosis. These processes are known to contribute to restenosis, a pathophysiological process often occurring in patients submitted to revascularization procedures. We aimed to test the effect of alpha-difluoromethylornithine (DFMO), a
Popular Abstract in Swedish Trots att "block- och ymp- sampolymerer" låter obekant i de flestas öron, kommer vi i kontakt med dem i det vardagliga livet. De kan användas till en rad olika produkter t.ex. leksaker, färg, papper, tvättmedel, läkemedel, kosmetika och i bilar. Denna avhandling handlar om framställning och karatärisering av ympsampolymerer, samt studier av deras egenskaper i vattenlösThe research underlaying this thesis involves synthesis and characterization of well-defined anionic graft copolymers carrying poly(ethylene oxide) (PEO) side-chains. Two different grafting techniques were used. Backbone polymers were prepared through radical terpolymerization of maleic anhydride, styrene and an additional comonomer. Poly(ethylene oxide) monomethyl ether (MPEO) were grafted onto
In a population-based, matched case-control study from the South Swedish Health Care Region, which has the highest risk for melanoma in Sweden, the relation between the use of sunbeds or sunlamps and malignant melanoma was investigated. Between July 1, 1988, and June 30, 1990, a total of 400 melanoma patients and 640 healthy controls aged 15-75 years answered a comprehensive questionnaire containi
Whole-tree harvesting, i.e. harvesting of stems, branches and tops, has become increasingly common during recent decades due to the increased demand for renewable energy. Whole-tree harvesting leads to an increase in base cation losses from the ecosystem, which can counteract recovery from acidification. An increase in weathering rates due to higher temperatures is sometimes suggested as a process
Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging shows myocardial fibrosis and is associated with outcome in repaired Tetralogy of Fallot (rToF). However, patients with rToF have surgical material implanted, also appearing bright in LGE images. Therefore, right ventricular myocardial fibrosis could be overestimated or falsely diagnosed, which may affect prognostic va
What takes place during the monitoring cycles of UN treaty bodies, and what impact do these cycles have both locally and globally? Movement in the Rights Direction explores these questions through the lens of the UN Human Rights Committee, the treaty body responsible for overseeing state compliance with the International Covenant on Civil and Political Rights (ICCPR), often considered the UN’s mos
Animals align their body in relation to different environmental cues, including spontaneous directional responses relative to the geomagnetic field known as magnetic body alignment. The biological significance of this behavior, however, remains undetermined for most taxa. In previous studies, migratory songbirds aligned their body with the cardinal directions of the geomagnetic field and their mig
Klibbiga grenar Föreställ dig, en stilla promenad i lätt vårregn. Känn doften av fuktig jord. Jorddoften kommer från jordlevande bakterierna som kallas Streptomyceter. Då dessa bakterier utgör en av våra viktigaste källor till antibiotika är de särskilt intressanta att studera. Men hur växer de egentligen? I stället för att föröka sig via celldelning bildar dessa bakterier stora nätverk, likt rötStreptomycetes grow as filamentous cells called hyphae. These cells elongate using a polar method of growth where the cell wall synthesis is restricted to the hyphal tips. It has been proved that the protein DivIVA directs the cell wall assembly to the poles and initiate branch formation along the lateral cell wall. Observations of DivIVA shows that it is regulated by AfsK, a Ser/Thr protein kinas
In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the
Following the Fish—an artistic research project exploring architecture, migration and collective practice through workshop-based methodologies—was presented in 2024 as part of the exhibition UnFold: Exploring Artistic Directions in Architectural Research at Lund University.The project was developed through a series of workshops across Barcelona, Lund and Venice, engaging with the spatial and socia
In Danish political discourse, social housing areas – also labelled migrant ‘ghettos’ – are currently strongly problematized, sometimes referred to as ‘holes in the national map of Denmark’ and described as fostering ‘parallel’ societies where gang cultures thrive and people live lives profoundly disengaged from the larger national community (cf. Johansen and Jensen 2017; Jensen 2016). Everyday li
Oligonucleotides are short fragments of RNA or DNA that can act as active pharmaceutical ingredients (API) in medicines used to target a wide range of diseases, with further applications continuously emerging. Solid Phase Oligonucleotide Synthesis (SPOS) remains the dominant platform for oligonucleotide production. However, SPOS is characterized by high reagent consumption and a poor sustainabilit
