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Due to the climate crisis we are facing, we can no longer consider current construction methods, which contribute to 40% of global CO₂ emissions, as an alternative to building. Vernacular architecture, in comparison, offers a sustainable alternative. People have experimented with this approach to designing, constructing, and living throughout time. This system essentially stands for maximizing eff
Foton för forskning och framtiden Kan lösningen på ett forskningsproblem vara din smartphone? Om vi frågar grundarna till projektet CoastSnap är svaret ja! CoastSnap är ett så kallat medborgarforskningsprojekt, vilket innebär att allmänheten deltar i forskning genom att hjälpa till med datainsamling. Kusten är ett utmanande forskningsområde, och i och med klimatförändringarna och den stigande havThe coast is an ever-changing environment, and due to climate change, coastal research is becoming more challenging. To detect changes in the coastline, such as erosion, researchers need large amounts of data over long periods of time. Part of the solution could be the citizen science project CoastSnap – a global community beach monitoring program. The aim of this study was to examine factors that
Sedan upptäckten av penicillin har mänskligheten lyckats kringgå bakteriella infektioner som tidigare varit dödliga. Men i takt med att användningen av antibiotika ökat, har bakterierna lärt sig att kringgå det. Dessa så kallade resistenta bakterier utgör ett stort hot mot människan, eftersom de i nuläget är svåra att stoppa – med följden att vissa bakteriella infektioner kanske återigen kommer klWith antimicrobial resistance emerging, this project is part of a larger effort to design novel antibacterial substances combating bacterial infections. On the road towards this, sialic acids have become of large interest. Having a vital role within cell signalling, adhesion and recognition in the human body, these 9-carbon α-keto sugars have opened a door for bacterial survival. By the help of si
I Sverige används gymnasiebetyg som ett urvalsinstrument för högre studier, varför det är särskilt allvarligt att de brister när det gäller exempelvis likvärdighet och inflationsresistens (Skolverket, 2020). Kvalitetsbrister i betygssättningspraktiker har visat sig särskilt närvarande i matematikundervisning (se t.ex. Korp, 2006). Studiens syfte var därför att undersöka hur gymnasielärare i matema
Popular Abstract in Swedish Den här avhandlingen består av fem papper (A-E) som samtliga är tillämpningar av Rice's formel. Tillämpningsområdena är inom oceanografi och miljö. De tre första papperna behandlar egenskaper hos mötande havsvågor, det vill säga vågor som ett fartyg möter när det seglar på havet. Papper A syftar till att hitta en formel för att räkna ut intensiteten av sådana vågor. SpThis thesis is based on five papers (A-E), all treating various applications of Rice's formula. The areas of application are oceanographic and environmental problems. The first three papers treat properties of encountering waves, that is, waves that a ship encounters while sailing on the ocean. Paper A addresses the problem of computing the intensity of such waves and, in particular, the intensit
PURPOSE: A previous study has shown age- and sex-related differences in abdominal aortic compliance. In that study blood pressure determined by auscultation in the brachial artery was assumed to be equal to blood pressure in the abdominal aorta. To validate our findings we investigated the pressure-diameter (P-D) relationship of the abdominal aorta. METHODS: Diameter and pulsatile diameter change
Popular Abstract in Swedish Kroppens immunförsvar, vars uppgift är att skydda oss mot infektioner, består av ett antal olika celltyper som till stor del finns i blodet. Immunförsvaret kan indelas i två delar; ett medfött försvar som är likadant hos alla individer och ett försvar som byggs upp under individens livstid. Det senare utformas olika beroende på vilka bakterier och virus som individen utThe cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granu
In a warming climate, permafrost is likely to be significantly reduced and eventually disappear from the sub-Arctic region. This will affect people at a range of scales, from locally by slumping of buildings and roads to globally as melting of permafrost will most likely increase the emissions of the powerful greenhouse gas methane, which will further enhance global warming. In order to predict fu
The development of models that provide accurate spatio-temporal predictions of ambient air pollution at small spatial scales is of great importance for the assessment of potential health effects of air pollution. Here we present a spatio-temporal framework that predicts ambient air pollution by combining data from several different monitoring networks and deterministic air pollution model(s) with
In this study, field experiments and numerical simulations for different drip irrigation treatments in a sandy loam soil were conducted to investigate soil water and salinity distribution as well as dye infiltration patterns. Three treatments, surface drip irrigation without and with plastic mulch (T1 and T2, respectively); and subsurface drip irrigation (T3), were used. In addition, daily and bi-
Aims: We assessed whether a novel programme to evaluate/communicate predicted coronary heart disease (CHD) risk could lower patients' predicted Framingham CHD risk vs. usual care. Methods: The Risk Evaluation and Communication Health Outcomes and Utilization Trial was a prospective, controlled, cluster-randomised trial in nine European countries, among patients at moderate cardiovascular risk. Fol
The central nervous system (CNS) monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of pro-opiomelanocortin (POMC) neurons which are critical regulators of energy balance. Consistent with a pivotal role of the melanocortin system in the control of energy
The aim of this study was to develop (68)Ga-SPIONs for use as a single contrast agent for dynamic, quantitative and high resolution PET/MR imaging of Sentinel Lymph Node (SLN). In addition (68)Ga enables Cherenkov light emission which can be used for optical guidance during resection of SLN. SPIONs were labeled with (68)Ga in ammonium acetate buffer, pH 5.5. The labeling yield and stability in hum
Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive aldehydes, including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modif
The microRNAs (miRNAs) miR-132 and miR-212 have been found to regulate synaptic plasticity and cholinergic signaling and recent work has demonstrated roles outside of the CNS, including in smooth muscle. Here, we examined if miR-132 and miR-212 are induced in the urinary bladder following outlet obstruction and whether this correlates with effects on gene expression and cell growth. Three to seven
Popular Abstract in Swedish Den här avhandlingen har behandlingsresultaten av permanent djupelektrod stimulering i hjärnan (Deep Brain Stimulation, DBS) undersökts ur såväl symptomminsknings som patients och närståendes perspektiv. DBS behandling innebär att en elektrod med fyra poler opereras in i hjärnan genom ett litet hål i skallbenet, och den kopplas till pulsgivardosa. Hela systemet är doltThe treatment related effects and personalized goal fulfilment of Deep Brain Stimulation (DBS) have been assessed in studies with different designs. The brain targets included the thalamus for medically intractable tremor in Parkinson's disease (PD) or essential tremor (ET) and the subthalamicus for reducing hypo-, bradykinesia, tremor, rigidity and dystonia in PD. A Swedish multi-center study sh
