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Head and neck squamous cell carcinoma (HNSCC) is a heterogenous cancer with poor prognosis, especially for patients with advanced or recurrent disease. The complex tumor microenvironment (TME) plays an important role in mediating immune evasion and therapy resistance. To improve preclinical testing, advanced 3D in vitro and ex vivo models such as spheroids, organoids, and tumor slice cultures have

Background and objective: We established prognostic nomograms incorporating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) parameters standardised by Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP1). Here, we develop an updated PPP2 risk score from a large international multicentre registry study. Methods: We included 6128 prostate cancer pati

Solpaneler på taket är numera en vanlig syn, men vart tar elen vägen när solen skiner som mest? I detta examensarbete har det undersökts hur flerbostadshus kan använda egna batterier för att spara pengar, bli mer självförsörjande och samtidigt stötta elsystemet. Svaret är att batterier kan löna sig, om de används smart. När elnätet blir allt mer pressat och produktionen från förnybar energi varierThis thesis examines the economic potential of lithium-ion battery storage systems in multi-family residential buildings in Sweden, focusing on profitability, revenue opportunities, and the factors influencing investment decisions. The increasing share of renewable electricity, combined with the electrification of society, has intensified the need for energy storage solutions capable of balancing

Importance: The ability to predict sudden cardiac death (SCD) in children and adolescents with hypertrophic cardiomyopathy (HCM) is currently inadequate. Late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) imaging is associated with SCD events in adults with HCM. Objective: To examine the prognostic significance of LGE in patients with HCM who are younger than 21 years. De

Throughout history, human civilisation and wildlife have instinctively settled close to water and coastlines out of necessity for resources. It has always been a natural instinct, yet we have also continually adapted to weather conditions and relocated when resources were found elsewhere. We have always been flexible and mobile, adapting to nature and allowing it to lead and guide us. With the ris

Saccharomyces cerevisiae: Genome editing and investigation of the peroxisome & beta-oxidation For thousands of years humans have used yeast to brew beer, bake bread and make wine. Nowadays, these microorganisms can be used to produce various chemicals and proteins. One interesting compound is capsaicin, found in the chili pepper plant and commonly used in food, but lesser-known for its applic

GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic reson

Background: The benefit of surgical resection for colorectal cancer (CRC) lung metastases is unclear. The aim was to investigate the incidence, treatment strategy, and 5-year overall survival (OS) in CRC patients with isolated lung metastases. Methods: This registry-based retrospective cohort study included patients treated with curative resection of CRC within the county of Skåne during the perio

Uppsatsen behandlar hur miljörelaterade fordringar hanteras när en verksamhet går i konkurs och i vilken utsträckning principen om att förorenaren ska betala får genomslag i svensk konkursrätt. Utgångspunkten är de praktiska problem som uppstår när kostsamma efterbehandlingsåtgärder aktualiseras först efter konkursutbrottet, samtidigt som det inte finns någon generell skyldighet för staten eller kThis thesis examines how environmental claims are treated when a business is declared bankrupt, and to what extent the polluter pays principle is upheld in Swedish bankruptcy law. The point of departure is the practical difficulties that occur when costly remediation measures become relevant only after the opening of bankruptcy proceedings, while there is no general legal obligation for the State

BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M

Background Trauma is the leading cause of quality-related mortality in low- and middle-income countries, with an estimated two million preventable deaths each year. Although trauma quality improvement programmes have been utilised in high-income countries for more than three decades, there is no high-level evidence of their effect on patient outcomes. We aimed to assess whether implementing a cont

Sweden’s grocery distribution is routed through a limited number of upstream hubs and relies on corridors and ferry links. When disruptions affect a hub or a critical link, reallocations propagate fast and travel times increase, with some areas losing coverage temporarily. Decentralising the whole system is costly, so targeted resilience options must be evaluated. The purpose of this thesis is to

Universitetsbibliotekets årsberättelse 2021 1 Universitetsbibliotekets årsberättelse 2023 LUNDS UNIVERSITET 2 Innehåll Starka framsteg och viktiga utmaningar .............................................................. 3 HÅLLBAR VERKSAMHET ............................................................................................... 4 Vårt hållbarhetsarbete .....................................

https://www.ub.lu.se/sites/ub.lu.se/files/2024-03/arsberattelse-2023-ej-tillganglig.pdf - 2026-05-29

Atmospheric inversions are used to derive constraints on the net sources and sinks of CO2 and other stable atmospheric tracers from their observed concentrations. The resolution and accuracy that the fluxes can be estimated with depends, among other factors, on the quality and density of the observational coverage, on the precision and accuracy of the transport model used by the inversion to relat

Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation

Older people make up an increasing proportion of the homeless population and their homelessness is often combined with problems such as substance use, mental illness and physical problems. While much research has focused on short-term shelters, food and clothing, less is known about arrangement providing permanent supportive housing where older homeless adults can stay the rest of their lives. Thi