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Enzymatic hydrolysis coupled to hot water extraction for determination of flavonoids in plants

Popular Abstract in Swedish I Sverige produceras dagligen flera ton biprodukter avfall inom jordbruks-, livsmedels- och skogsindustrierna. Detta avfall förbränns, komposteras och går till biogasproduktion samt i vissa fall till djurfoder. Intressanta avfallsgrupper ur ett svenskt perspektiv är lök- morots-, och potatis avfall från jordbruk- och livsmedelsindustrin och bark från skogsindustrin. DesThe word sustainability is more and more frequently used within the field of chemistry and in many other fields. Green or sustainable chemistry was introduced during the 90 ́s as a field of chemistry where the environmental and health impacts of processes and products are evaluated and improved. Within analytical chemistry the awareness of sustainability has also increased, which has resulted in o

Antibody Evolution and Repertoire Development

Popular Abstract in Swedish Antikroppar är viktiga beståndsdelar av det naturliga immunförsvaret som skyddar oss mot smittämnen, såsom bakterier och virus. Utvecklingen av olika genetiska och biokemiska teknologier har dessutom möjliggjort användningen av antikroppar för en mängd ändmål, bl a för diagnostik och behandling av infektionssjukdomar och cancer. I denna avhandling, som bygger på fem vetAntibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. Despite tremendous advances in all fields

Enhanced 3D-GIS : Documenting Insula V 1 in Pompeii

This project was recently carried out as a part of The Swedish Pompeii Project, which was started in 2000 as a research and fieldwork activity initiated by the Swedish Institute in Rome. The aim was to record and analyze an entire Pompeian city block, Insula V 1. Since autumn 2011 a new branch of advanced digital archaeology, involving 3D reconstructions and documentation methods, was added to the

Metal-Organic Complexes at Surfaces

The adsorption of different metal-organic complexes at surfaces was investigated by spectroscopic techniques (x-ray photoemission spectroscopy, x-ray absorption spectroscopy, resonant photoemission spectroscopy) and by scanning tunnelling microscopy. The investigation methods are able to provide atomic scale information on the studied systems, which moreover originates from the top-most atomic lay

Single versus serial measurements of neuron-specific enolase and prediction of poor neurological outcome in persistently unconscious patients after out-of-hospital cardiac arrest - A TTM-trial substudy

Background: Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients

Seeking explanations for recent changes in abundance of wintering Eurasian Wigeon (Anas penelope) in northwest Europe

We analysed annual changes in abundance of Eurasian Wigeon (Anas penelope) derived from mid-winter International Waterbird Census data throughout its northwest European flyway since 1988 using log-linear Poisson regression modelling. Increases in abundance in the north and east of the wintering range (Norway, Sweden, Denmark, Germany, Switzerland), stable numbers in the central range (Belgium, Net

Whole-remnant and maximum-voxel SPECT/CT dosimetry in 131I-NaI treatments of differentiated thyroid cancer

Purpose: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC). Methods: Eighteen DTC patients were administered 1.11 GBq of 131I-NaI after near-total thyroidectomy and rhTSH stimulation. Two patients had two remnants, so in total dosimetry was performed f

Markers of Atrial Myopathy in the General Population : Prevalence, Predictors, and Inter-Relations

BACKGROUND: Atrial myopathy refers to structural and functional cardiac abnormalities associated with atrial fibrillation and stroke, but appropriate diagnostic criteria are lacking.OBJECTIVES: This study aimed to assess prevalence, clinical correlates, and overlap between potential atrial myopathy markers.METHODS: The population-based SCAPIS (Swedish CArdioPulmonary bioImage Study) prospectively

Signaling to the immature brain - Choroid plexus, insulin-like growth factor 1 and extracellular vesicles

I Sverige överlever idag uppemot 80% av de barnen som är födda extremt för tidigt (födda innan graviditetsvecka 28). Dock medföljer en hög sjuklighet, där uppemot 20% av barnen utvecklar olika sjukdomstillstånd såsom blödning i hjärnas hålrum, även kallat intra-ventrikulär hjärnblödning (IVH). Dessutom löper de extremt för tidigt födda barnen en ökad risk att utveckla en intellektuell och neurologExtremely preterm infants (i.e., born below 28 gestational weeks), are at high risk of developing brain morbidities including intraventricular hemorrhage (IVH) and neurodevelopmental impairment. Despite over 50 years of research, there is currently no effective therapy available for preventing IVH. Insulin-like growth factor 1 (IGF-1) plays a pivotal role in perinatal development. Extremely preter

Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab

Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated significant treatment effects across primary and secondary endpoints. Low-dose aducanumab results were consistent across studies with non-significant differ

Psychometric evaluation of the electronic faces thermometer scale for pain assessment in children 8–17 years old: A study protocol

It is often a challenge for a child to communicate their pain, and their possibilities to do so should be strengthened in healthcare settings. Digital self-assessment provides a potential solution for person-centered care in pain management and promotes child participation when a child is ill. A child's perception of pain assessment differs when it is assessed using digital or analog formats. As w

Arginine "magic" : Guanidinium Like-Charge Ion Pairing from Aqueous Salts to Cell Penetrating Peptides

It is a textbook knowledge that charges of the same polarity repel each other. For two monovalent ions in the gas phase at a close contact this repulsive interaction amounts to hundreds of kilojoules per mole. In aqueous solutions, however, this Coulomb repulsion is strongly attenuated by a factor equal to the dielectric constant of the medium. The residual repulsion, which now amounts only to uni

Hydrothermal carbon release to the ocean and atmosphere from the eastern equatorial Pacific during the last glacial termination

Arguably among the most globally impactful climate changes in Earth's past million years are the glacial terminations that punctuated the Pleistocene epoch. With the acquisition and analysis of marine and continental records, including ice cores, it is now clear that the Earth's climate was responding profoundly to changes in greenhouse gases that accompanied those glacial terminations. But the u

Essays in Applied Microeconomics

This thesis consists of four self-contained papers in applied microeconomics. The first paper asks how a neighbors purchase of a specific good affects a households likelihood of purchase. I use an image classification algorithm to process a large set of aerial photos in order to infer household ownership of a visible durable good, specifically a trampoline. To estimate the neighborhood effect, I u

Valvular imaging in the era of feature-tracking : A slice-following cardiac MR sequence to measure mitral flow

BACKGROUND: In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging of the mitral valve, however, is challenging, since it moves in and out of the image plane during the cardiac cycle.PURPOSE: To more accurately measure mitral flow, a slice-following MRI phase contrast sequence is proposed. This study aimed to implement such

Exploring the Effects of Deep Brain Stimulation and Vision on Tremor in Parkinson's Disease : Benefits from Objective Methods

BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee

Early Paleogene biosiliceous sedimentation in the Atlantic Ocean : Testing the inorganic origin hypothesis for Paleocene and Eocene chert and porcellanite

The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~

Differences in incubation behaviour and niche separation of two competing flycatcher species

Abstract: Food availability sets the stage for incubation behaviour of a female bird and thereby indirectly determines the nest temperature, which in turn affects development and metabolism of avian embryos. Changes in development and metabolism in turn are known to influence offspring’s ability to adjust to environmental changes later in life. However, few studies have investigated the role of in