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Background: Carry Life UF is a novel peritoneal dialysis (PD) technology for improved fluid management using steady concentration PD (SCPD). The Carry Life UF treatment starts with a manual peritoneal fill of 1.36% glucose PD fluid, followed by a 5-hour treatment where small amounts of glucose are continuously added to maintain a stable intraperitoneal glucose concentration. A recent in-center cli
Fine-grained windblown deposits, known as loess, in which fossil soils (palaeosols) are preserved, serve as excellent records of past climate. However, paleoclimate reconstruction studies on loess-palaeosol sequences (LPS) in Southeastern Europe have primarily focused on climate changes during the last one or two glacial-interglacial cycles. Surprisingly, little attention has been given to the cli
Bakgrund: Den kurativa behandlingen för resektabla lokalt avancerade stadier av cancer i munhålan innefattar i regel en kombination av kirurgi och radioterapi (RT). Huruvida RT bör ges först och därefter följas av kirurgi, eller om tumören bör opereras bort först, följt av RT postoperativt, har dock inte studerats i någon större omfattning.Syfte: Denna avhandling undersöker olika aspekter av pre- Background: The curatively intended treatment for resectable locally advanced stages of oral cavity cancer (OCC) generally involves a combination of surgery and radiotherapy (RT). However, whether to apply RT first and then proceed with surgery, or to resect the cancer and subsequently administer RT, has not been extensively studied. Aims: This thesis examines various aspects of pre- versus postop
Background: Magnetic resonance imaging (MRI) is recommended by guidelines to evaluate the severity of brain ischemia after cardiac arrest for functional outcome prediction. However, standardized assessment criteria are lacking. We have developed a semi-quantitative Cardiac Arrest Brain Ischemia (CABI) score to assess the extension of brain ischemia on MRI. Objectives: To evaluate the prognostic pe
Retrieving episodic memories often involves reconstructing both their semantic content and the emotional context in which they occurred. However, the neural mechanisms that differentiate these forms of reinstatement remain poorly understood. This event-related potential (ERP) study examines how semantic category and emotional valence are reinstated during memory retrieval.Seventy participants enco
Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,
BACKGROUND: Frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominant atrophy is an emerging area of interest. Recent findings by the International Working Group (IWG) have identified this subtype as having a distinct clinical profile within the FTD spectrum (Ulugut et al., 2024, A&D). However, its genetic and pathological underpinnings remain unexplored in large, mult
INTRODUCTION: Since the last two decades, there has been a dramatic rise in caesarean sections (CS) throughout the world. This increase has been seen even in Europe, where rates vary significantly from 17% in Northern Europe to 56% in the South. Although, CS can be a lifesaving intervention when medically necessary, non-essential CS are associated with short- and long-term complications for both t
Importance Substantial improvements in childhood cancer survival have created a critical need to address serious long-term health complications, such as valvular heart disease (VHD). Objective To identify treatment-related risk factors for VHD in a large European cohort of long-term childhood cancer survivors. Design, Setting, and Participants This nested case-control study used data from the PanC
BACKGROUND: Postmortem MRI has opened-up avenues to study brain structure at ultra high-resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple-mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem MRI. Additionally, we provide a framework to perform point-wise surface-based group-level studi
Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. The surface associated M protein of Streptococcus pyogenes, a common human pathogen, exhibits antigenic variation due to an N-te
Northern Europe was capped by ice during Weichsel (Wurm), the maximum of which occurred approximately 18,000 years before present. When in the latter part of the 19(th) century the view of an all-devastating land ice (the tabula rasa hypothesis) was generally adopted by natural scientists, plant biogeographers used a simple model predicting a post-glacial, northwards re-migration of species in con
Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and
Popular Abstract in Swedish Ett beta-fosfoglukomutas i kolhydrat-metabolismen hos Lactococcus lactisPhosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two distinct forms of PGM have been purifed and charactierized in Lactococcus lactis growing on maltose: one specific for the alpha-isomer, and the other specific for the beta-isomer of glucose 1-phosphate. Beta-PGM was purified and polyclonal antisera to the enzyme were generated. Beta-PGM
The southern section of the Mylonite Zone (MZ) is a major lithotectonic terrane boundary in the SW Baltic Shield. It separates the parautochthonous Eastern Segment of the Sveconorwegian orogen from the allochthonous Western Segment. Complex zircons in migmatised and banded orthogneisses along the southern MZ were investigated by ion microprobe analyses guided by backscattered electron imaging to d
Amorphous Silica (ASi) is present in considerable amounts in most soils and serves as a (micro-)nutrient for many plants. However, our understanding of the response of this important nutrient pool to human or natural disturbances is still very limited. One of the reasons for this is the long time scales involved. This explorative study focuses on the effect of a historical agricultural system, cal
GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was r
