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Varje cell har ett membran som skapar en gräns mot omvärlden och skyddarcellen. Men cellen måste alltjämt utbyta viktiga molekyler med omvärlden för attöverleva. Därför finns specialiserade proteiner, som sitter i membranen och utgörportar i denna barriär. Denna avhandling fokuserar på två membranproteiner, enprotonpump och en jonkanal.Varje dag i våra liv använder vi hjärnan, muskler och hjärtat.NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. In the hydrophilic domain electrons from NADH oxidation are transported via a wire of iron-sulfur

A total of 16 global chemistry transport models and general circulation models have participated in this study; 14 models have been evaluated with regard to their ability to reproduce the near-surface observed number concentration of aerosol particles and cloud condensation nuclei (CCN), as well as derived cloud droplet number concentration (CDNC). Model results for the period 2011-2015 are compar

This thesis focuses mainly on the co-integration of vertical nanowiren-type InAs and p-type GaSb MOSFETs on Si (Paper I & II), whereMOVPE grown vertical InAs-GaSb heterostructure nanowires areused for realizing monolithically integrated and co-processed all-III-V CMOS.Utilizing a bottom-up approach based on MOVPE grown nanowires enablesdesign flexibilities, such as in-situ doping and heterostr

I denna rapport redovisas populationstrender för 175 svenska fågelarter för åren 1975–2010. Fåglarna har räknats på vintern och på sommaren enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren men täcker hela Sverige. De har räknats sedan 1996. Vintern 2009/2010 räknades nästan 300 We present the results of the Swedish Bird Survey, run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2010 include data from 622 winter point count routes in 2009/2010 (35th winter), of which 281 were carried out during the Christmas/New Year count and 262 summer point count routes (36th

In blood, the oxygen-transporting protein hemoglobin (Hb) governs the oxygenation of cells and tissues. Naturally, this protein has claimed a place in the center of the research field of artificial oxygen therapeutics. Such Hb-based products have used cell-free Hb purified from human, bovine, invertebrate, or recombinant sources to create hemoglobin-based oxygen carriers (HBOCs). However, administ

Aim/hypothesis: Human enteroviral infections are suggested to be associated with type 1 diabetes. However, the mechanism by which enteroviruses can trigger disease remains unknown. The present study aims to investigate the impact of enterovirus on autophagy, a cellular process that regulates beta cell homeostasis, using the clonal beta cell line INS(832/13) and human islet cells as in vitro models

Human activities have a huge impact on the carbon cycle by modifying the landscape. Vegetation cover changes attributed to forest clearance and the expansion of agricultural land increases soil erosion, organic matter and other nutrient delivery from terrestrial to aquatic ecosystems. Long-term records of environmental variation at centennial to millennial time scales are essential for the assessm

The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. The movement of CSF from the PVS and through the brain is dependent on the polarised expression of aquaporin-4 (AQP4) at astrocyte endfe

The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est

Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. In the clinical setting, disease management has heavily relied on the sole targeting of malignant cells but, except

Background: Intraventricular haemorrhage (IVH) is a major complication of preterm birth. Large haemorrhages are associated with a high risk of disability and hydrocephalus. Instability of blood pressure and cerebral blood in the newborn flow are postulated as causative factors. Another mechanism may involve reperfusion damage from oxygen free radicals. It has been suggested that phenobarbital stab

Deepwater drilling operates high hazardous and complex systems. Technological and operational complexities, harsh environmental conditions, geological uncertainties, and high-pressure flammable fluids are some of the critical factors that pose clear threats towards safe operations and may result in high consequence events, as the Macondo blowout in 2010. The continuous demand for oil and gas push

Title: Direct Material Safety Stock Standard Authors: Oscar Gustavsson, Oskar Strömberg Supervisors: Gustaf Lilja, IKEA Industry Eva Berg, Division of Industrial management and logistics, Lund University Contribution: This thesis has been a complete elaboration between the two authors. Each author has been involved in every part of the process. Background: In a time when everything is available at

This master thesis was partly performed as a field study in Gaborone, the capital city of Botswana, located in southern Africa. The semi-arid climate in Botswana together with a rapid financial development in the country during the last decades has increased the need for water. The last years the water situation has been strained in Gaborone, and Gaborone dam which used to be one of the city’s dri

Denna uppsats baserar sig på en utredning av Försäkringskassan, som presenterades i maj 2005. Titeln var Utredning om könsneutralt och delat barnbidrag. Försäkringskassan hade fått i uppdrag av regeringen att utreda förutsättningarna för att göra lagstiftningen kring barnbidraget könsneutral och införa en möjlighet för föräldrarna att kunna dela bidraget mellan sig. Den nuvarande barnbidragslagsti

Background: Emerging evidence suggests that artificial intelligence (AI) can increase cancer detection in mammography screening while reducing screen-reading workload, but further understanding of the clinical impact is needed. Methods: In this randomised, controlled, parallel-group, non-inferiority, single-blinded, screening-accuracy study, done within the Swedish national screening programme, wo

COSB30 Schedule and readings 1 Course Outline COSB30: China Today 31 October 2022 to 15 January 2023 Course Convener Stefan Brehm Contact: stefan.brehm@ace.lu.se Teachers: Stefan Brehm, Tabita Rosendal Ebbesen, Gina Song Lopez, Marina Svensson, Jinyan Zeng Lecture 1: Introduction and political system (Marina), 31 October, 13.15 – 15.00 Joseph, William A. (ed.) (2019). Politics in China: An Introdu

https://www.ace.lu.se/sites/ace.lu.se/files/2022-10/COSB30%20Schedule%20and%20readings.pdf - 2026-06-30