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A combination of access to preassociation sites and local accumulation tendency in the direct vicinity of G-N7 controls the rate of platination of single-stranded DNA
Adduct formation between cationic reagents and targets on DNA are facilitated by the ability of DNA to attract cations to its surface. The electrostatic interactions likely provide the basis for the documented preference exhibited by cisplatin and related compounds for nuclear DNA over other cellular constituents. As an extension of a previous communication, we here present an investigation illust
Hematopoietic secretory granules as vehicles for the local delivery of cytokines and soluble cytokine receptors at sites of inflammation.
Cytokines play an important role in the regulation of homeostasis and inflammation. A de-regulated cytokine function can subsequently promote chronic inflammation. This is supported by clinical evidence showing the beneficial effect of inhibiting TNF-alpha through injection of antibodies and soluble receptor in disorders such as rheumatoid arthritis and Crohn's disease. Systemic anti-TNF-alpha the
Sorting of soluble TNF-receptor for granule storage in hematopoietic cells as a principle for targeting of selected proteins to inflamed sites.
Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting
A DFT investigation on structural and redox properties of a synthetic Fe6S6 assembly closely related to the [FeFe]-hydrogenases active site
Identification of Noncollagenous Sites Encoding Specific Interactions and Quaternary Assembly of alpha 3 alpha 4 alpha 5(IV) Collagen IMPLICATIONS FOR ALPORT GENE THERAPY
Association of the Collagen Type 1 (COL1A 1) Sp1 Binding Site Polymorphism to Femoral Neck Bone Mineral Density and Wrist Fracture in 1044 Elderly Swedish Women.
Escherichia coli RNase E and RNase G cleave a Bacillus subtilis transcript at the same site in a structure-dependent manner
The decay of Bacillus subtilis aprE leader-lacZ mRNA was examined in Escherichia coli wild-type and in mutants deficient in RNase E, RNase G, or both. Two versions of the mRNA were studied: the wild-type mRNA, which has a stem-loop at the 5' end, and a mutant mRNA, with a single-stranded 5' end. The half-life of both transcripts was determined by RNase E, the half-life of the mutant transcript bei
Defining and applying surrogate safety measures and behavioural indicators through site-based observations
Role of adenine and guanine sites in hole hopping in dna nanowire
Transfer integrals for oligos with different bases have been calculated using INDO/Koopman's approximation to unveil the charge transport mechanism in DNA. The sequences, G(A)nG, n = 1, 2, …, 10; G(A)xG(A)yG, x + y = 9; and G(A)xG(A)yG(A)zG, x + y + z = 8, were employed to interpret the Guanine (G) and Adenine(A) hopping. Adenine hopping is found to be faster in G(A)nG sequences with longer Adenin
New properties of Bacillus subtilis succinate dehydrogenase altered at the active site
Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120
Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if present, the resolving Cys (CR). A detailed catalytic cycle has been derived for typical 2-Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs. We have
A microgel-Pickering emulsion route to colloidal molecules with temperature-tunable interaction sites
Attraction of male turnip moths Agrotis segetum (Lepidoptera : Noctuidae) to sex pheromone components and their mixtures at 11 sites in Europe, Asia, and Africa
A novel function for CDK2 activity at meiotic crossover sites
The Raunis section, central Latvia, revisited : first luminescence results and re-evaluation of a key Baltic States stratigraphic site
Smoking increases donor site complications in breast reconstruction with DIEP flap
Objective: Reconstruction with deep inferior epigastric perforator flap (DIEP) is considered to be the first choice for autologous breast reconstruction. The primary aims of this retrospective study were to find out if differences in smoking habits and BMI are useful predictors for postoperative complications in DIEP surgery. Methods: Three hundred and one patients were included. Data regarding sm