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Sequence and context dependence of EF-hand loop dynamics. An 15N relaxation study of a calcium-binding site mutant of calbindin D(9k)

The influence of amino acid sequence and structural context on the backbone dynamics of EF-hand calcium-binding loops was investigated using 15N spin relaxation measurements on the calcium-free state of the calbindin D(9k) mutant (A14D+A15Δ+P20Δ+N21G+P43M), in which the N-terminal pseudo- EF-hand loop, characteristic of S100 proteins, was engineered so as to conform with the C-terminal consensus E

Southern travelling habits with special reference to tumour site in Swedish melanoma patients

Southern travelling habits were recorded for 127 melanoma patients from southern parts of Sweden (the 56th latitude), 55 thyroid cancer patients, 100 non-Hodgkin's patients and 794 healthy controls from the same region. Melanoma patients were found to travel significantly more often south of the 45th latitude, as compared with patients with non-Hodgkin's lymphoma or thyroid carcinoma (RR = 2.2 for

Synthesis of Double-Modified Xyloside Analogues for Probing the β4GalT7 Active Site

Monosubstituted naphthoxylosides have been shown to function as substrates for, and inhibitors of, the enzyme β4GalT7, a key enzyme in the biosynthetic pathway leading to glycosaminoglycans and proteoglycans. In this article, we explore the synthesis of 16 xyloside analogues, modified at two different positions, as well as their function as inhibitors of and/or substrates for the enzyme. Seemingly

Fracture mapping using seismic amplitude variation with offset and azimuth analysis at the Weyburn CO2 storage site

Cap rock integrity is an essential characteristic of any reservoir to be used for long-term CO 2 storage. Seismic AVOA (amplitude variation with offset and azimuth) techniques have been applied to map HTI anisotropy near the cap rock of the Weyburn field in southeast Saskatchewan, Canada, with the purpose of identifying potential fracture zones that may compromise seal integrity. This analysis, su

Does a good story prompt visit intention? Evidence from the augmented reality experience at a heritage site in China

The emergence of digital technology has led researchers, businesses, and entrepreneurs to reflect more on the potential value that Augmented Reality (AR) can play in tourism. Although the relationship between authenticity and travel intention has been examined previously, little is known about how authenticity influences tourist travel intention after an AR experience. To fill this research gap, t

On-Site X-ray Fluorescence Spectrometry Measurement Strategy for Assessing the Sulfonation to Improve Chemimechanical Pulping Processes

Minimizing the fiber property distribution would have the potential to improve the pulp properties and the process efficiency of chemimechanical pulp. To achieve this, it is essential to improve the level of knowledge of how evenly distributed the sulfonate concentration is between the individual chemimechanical pulp fibers. Due to the variation in quality between pulpwood and sawmill chips, as we

Exploring non-immersive virtual reality experiences in tourism : Empirical evidence from a world heritage site

With the popularization of the concept of the metaverse, non-immersive virtual reality (VR) has become a focus of tourism destination marketing. Drawing upon telepresence theory, this study identifies the antecedents and consequences of telepresence to help interpret tourist behavior in the context of non-immersive VR experience. Results revealed that mental imagery and vividness positively predic

Oligosaccharide-receptor interaction of the Galα1-4Gal binding adhesin of Streptococcus suis : Combining site architecture and characterization of two variant adhesin specificities

The sugar binding specificities of two groups of Streptococcus suis, a pig pathogen that causes meningitis also in man, were determined. Both the group represented by a recently characterized strain inhibitable by galactose and N-acetylgalactosamine (type PN) and the group inhibitable by galactose (type PO) were found by hemagglutination and solid-phase binding inhibition experiments to recognize