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Recently, many genome-wide profiling studies provided insights into the molecular make-up of major cancer types. The deeper understanding of these genetic alterations and their functional consequences led to the discovery of novel therapeutic opportunities improving clinical management of cancer patients. While tissue-based molecular patient stratification is the gold standard for precision medici

The cleavage fracture probability of ferritic and ferritic/martensitic steels is generally computed using Beremin's model. In this work, a novel approach is developed for Beremin's model to be applicable to crack tip conditions under nonself similar stress field. The modification of Beremin's model corrects the inaccurate integration of local cleavage fracture probabilities of reference volume ele

Background: Growing up with congenital heart disease (CHD) often means transfer to adult care and lifelong medical follow-up. An optimal transition process usually involves a multipart collaboration between the patient, their parents and other family members, and the healthcare providers. Taking an active role while knowing when it is time to step aside can be difficult for all the concerned parti

The development of a high precision five rotation axes polarimeter using transmission multilayers as polarizers and reflection multilayers as analyzers is presented. In order to cover a wide energy range from EUV to soft X-ray, a set of Mo/Si, Cr/C, Sc/Cr, and W/B4C multilayers for transmission and reflection have been designed and fabricated. A hexapod support allows to align the polarimeter easi

One of the greatest impediments to the use of probabilistic reasoning in legal arguments is the difficulty in agreeing on an appropriate prior probability for the ultimate hypothesis, (in criminal cases this is normally “Defendant is guilty of the crime for which he/she is accused”). Even strong supporters of a Bayesian approach prefer to ignore priors and focus instead on considering only the lik

ClpP is the proteolytic subunit of the ATP-dependent Clp protease in eubacteria, mammals and plant chloroplasts. Cyanobacterial ClpP protein is encoded by a multigene family, producing up to four distinct isozymes. We have examined the importance of the first ClpP protein (ClpP1) isolated from the cyanobacterium Synechococcus sp. PCC 7942 for acclimation to ecologically relevant UV-B and low-tempe

The synthesis and structural characterization of the hitherto unknown parent Co(bz)2 + (bz=benzene) complex and several of its derivatives are described. Their synthesis starts either from a CoCO5 + salt, or directly from Co2(CO)8 and a Ag+ salt. Stability and solubility of these complexes was achieved by using the weakly coordinating anions

Nonfullerene acceptors (NFAs)-based organic solar cells (OSCs) have recently drawn considerable research interests; however, their excitonic dynamics seems quite different than that of fullerene acceptors-based devices and remains to be largely explored. A random terpolymer of PBBF11 to pair with a paradigm NFA of 3,9-bis(2-methylene-(3-(1,

Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graft outcome already at the progenitor stage remains a challenge. Here, we took an unbiased approach to

During the design and construction of house walls, certain factors such as building materials and external climatic conditions, which are essentials and influence in human comfort, are generally ignored. The rice husk is one of the most common organic wastes generated around the word, and in Ecuador this is not an exception. The aim of this work is to study the feasibility of using a mortar which

If an accident or attack involving radiological or nuclear material were to happen, people from the general public would be at risk of exposure to ionising radiation. Unlike people working with ionising radiation, for whom level of exposure to radiation is constantly monitored with dosemeters, people from the general population do not wear dosemeters; thus, the dose estimations for these individua

A modified local error model is developed for numerical integration of ODEs with invariants. The basic idea is to use a commutativity relationship that holds for implicit state-space form methods. A new implicit state-space form predictor is developed from which error estimates can be obtained by predictor-corrector difference: This technique is demonstrated through the preliminary examples in thi

Background: Sierra Leone is a low income country in West Africa that has a history of conflict. Sierra Leone have signed and ratified the Convention of Rights of Persons with Disabilities.Aim: To evaluate persons with disability that use prosthetic and orthotic assistive devices access to human rights. The addressed areas were; right to health, right to a standard of living adequate for health, ri

In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported ever having used sunbeds. A significantly elevated odds ratio for developing malig

Efficient visible-light-driven photocatalysis can be achieved over conventional wide band gap semiconductor, in which iodinated SnO2 quantum dots (QDs) are synthesized via hydrolysis of crystalline SnI4 in the absence of any additives or templates. The formation of SnO2 QDs reveals a wide preparation window and a very fast growth rate in minute scale. The iodine species may only exist on the surfa