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Enhancement Requests 2023

Presentation template with LiU typography The management of enhancement requests – a customer perspective EBSCO Systems Swedish User Group Annual meeting 2023 Eva Sejmyr, Senior Librarian and System Manager, Linköping University Library Let's explore the management of enhancement requests from a customer perspective, with examples from Linköping University Library and ESSUG. 2023-04-26The manageme

https://www.ub.lu.se/sites/ub.lu.se/files/2023-05/Enhancement%20requests%202023.pdf - 2026-05-08

Optimising performance in clinical capsule endoscopy

Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

Studies on Neuropsychiatric Manifestations and Genetic Factors in Systemic Lupus Erythematosus

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou

The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest

BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p

Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl