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Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta- and gamma-subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I mole
This paper presents a search for Higgs bosons decaying to four leptons, either electrons or muons, via one or two light exotic gauge bosons Z(d), H -> ZZ(d) -> 4l or H -> Z(d)Z(d) -> 4l. The search was performed using pp collision data corresponding to an integrated luminosity of about 20 fb(-1) at the center-of-mass energy of root s = 8 TeV recorded with the ATLAS detector at the Large Hadron Col
Although the importance of New Institutional Economics and the institutional approach for understanding pre-industrial economic development and the early growth of markets are widely accepted, it has proven to be difficult to assess more directly the effects of institutions on the functioning of markets. This paper uses empirical research on the rise of markets in late medieval Holland to illumina
Background: Practices regarding hospitalisation of children at diagnosis of type 1 diabetes vary both within countries and internationally, and high-quality evidence of best practice is scarce. The objective of this study was to close some of the gaps in evidence by comparing two alternative regimens for children diagnosed with type 1 diabetes: hospital-based care and hospital-based home care (HBH
Interest in human heredity has a long history in Sweden. In the 1920s the Parliament decided on a State institute for race biology and in the 1930s a sterilization legislation that put eugenics into practice was enacted. During the postwar decades both research and the political-medical practices were successively transformed: medical genetics became established and proclaimed as a new research fiInterest in human heredity has a long history in Sweden. In the 1920s the Parliament decided on a State institute for race biology and in the 1930s a sterilization legislation that put eugenics into practice was enacted. During the postwar decades both research and the political-medical practices were successively transformed: medical genetics became established and proclaimed as a new research fi
Previous research has established that when engaged in episodic memory retrieval, people frequently look at locations associated with the sought-after memory trace, even if those locations no longer contain any information. While it has been further demonstrated that gaze positions showing compatibility between encoding and retrieval increase the likelihood of successful remembering (Johansson &amPrevious research has established that when engaged in episodic memory retrieval, people frequently look at locations associated with the sought-after memory trace, even if those locations no longer contain any information. While it has been further demonstrated that gaze positions showing compatibility between encoding and retrieval increase the likelihood of successful remembering (Johansson &am
Despite controversies, flu vaccine programs targeted to the older people are highly recommended and represent a common public health policy in industrialized Countries. Although demographic aging will increase the share of population at higher risk of influenza, today economic recession is putting public budgets under pressure. Underfunding of prevention is becoming a larger problem, as prevention
In 1736 Samuel Hesselius, former pastor for the Swedish parishes in Pennsylvania, donated a collection of ‘American curiosities’ to Lund University in Sweden. Within less than twenty years, however, the collection had apparently disappeared. In the course of the past three decades the lost ethnographic artefacts have received increasing attention, but for a variety of reasons the collection has re
This Letter presents a search for new light resonances decaying to pairs of quarks and produced in association with a high-pT photon or jet. The dataset consists of proton–proton collisions with an integrated luminosity of 36.1 fb−1 at a centre-of-mass energy of s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Resonance candidates are identified as massive large-radius jets wi
The presence of graphite particles in gray cast iron commonly implies a good machinability, especially if compared to common steels. However, increasing industrial demands have resulted in a new interest for high-speed machining of these materials with higher performing tool materials than the traditionally used. Thus, the research presented in this paper focuses on evaluating the active tool wear
This self-study documents two teacher educators’ professionalinquiry into the notions of critical friendship. Specifically, we asked:How does our interactive inquiry on the topic of critical friendshiplead us to new understandings of critical friends? Three theoreticalperspectives framed this study – More Knowledgeable Others,Thought Collective, and reflection. Data sources included (a) artifactsfThis self-study documents two teacher educators’ professional inquiry into the notions of critical friendship. Specifically, we asked: How does our interactive inquiry on the topic of critical friendship lead us to new understandings of critical friends? Three theoretical perspectives framed this study – More Knowledgeable Others, Thought Collective, and reflection. Data sources included (a) artif
Multi-dimensional harmonic retrieval (HR) in white noise is required in numerous applications such as channel estimation in wireless communications and imaging in multiple-input multiple-output radar. In this paper, we propose two R-dimensional (R -D) extensions of the subspace-based MUSIC model order selection scheme, for R≥2R≥2, to detect the number of multi-dimensional cisoids. The key idea in
Information and Communication Technology (ICT) is perhaps the most important, emblematic and ubiquitous technology of contemporary society. ICT is used increasingly in new product areas and help resolve problems and challenges to mankind; it has even gotten to a point where life without ICT is hard to imagine. Over the last decades ICT has become a core technology within the music, literature an
A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming subsequent decay to a W boson and a b quark, t'(t) over bar' -> W(+)bW(-)(b) over bar. The search is based on 1.04 fb(-1) of proton-proton collisions at root s = 7 TeV collected by the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton + jets final state, chara
Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re
Children with cerebral palsy who are non-ambulant cannot stand or walk independently. In Sweden, daily static standing is part of standard care for these children even though it is time-consuming and costly, and while it may benefit the well-being of many children, it is inconvenient for others. A novel stander enables dynamic standing through walking movements. The aim of this study was to compar
