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A key question for evidence-based medicine (EBM) is how best to model the way in which EBM should “[integrate] individual clinical expertise and the best external evidence” (Sackett et al. 1996). We argue that the formulations and models available in the literature today are modest variations on a common theme and face very similar problems. For example, both the early and updated models of eviden
With the projected increase in the number of hydrogen-fueled trucks, it can be expected that it will become more common for such vehicles to be involved in road collisions. Even if hydrogen vehicles are designed with a quick-closing valve on tanks in accordance with UN/ECE R134, a small volume of hydrogen will be contained downstream of this valve and in the fuel-cell recirculation system and ther
As decolonization transformed world geopolitics, various Eastern Europeanauthoritarian ultranationalist groups sought to instrumentalize anti-imperialism in their attempts to launch a violent overthrow of the socialist regimes of the Soviet bloc. As the USSR underwent a transformation from the radical anti-imperialism of the 1920s to certain imperial attributes following the announcement of the BrAs decolonization transformed world geopolitics, various Eastern Europeanauthoritarian ultranationalist groups sought to instrumentalize anti-imperialism in their attempts to launch a violent overthrow of the socialist regimes of the Soviet bloc. As the USSR underwent a transformation from the radical anti-imperialism of the 1920s to certain imperial attributes following the announcement of the Br
This study investigates understandings of the concept of ‘participation’ within the context of a Swedish school, focusing on the differing perspectives of teachers, students, and school leaders. Despite a long-standing tradition in Sweden of recognizing children’s rights to influence their education, there remains considerable variation in how participation is understood and implemented among variThis study investigates understandings of the concept of ‘participation’ within the context of a Swedish school, focusing on the differing perspectives of teachers, students, and school leaders. Despite a long-standing tradition in Sweden of recognizing children’s rights to influence their education, there remains considerable variation in how participation is understood and implemented among vari
Purpose: The main objective of this thesis is to examine the effect different drivers of agency costs have on corporate cash holdings in public and private German technology firms. The analysis identifies three potential sources of agency costs. By determining target cash levels first and then obtaining deviations from these targets, the influences of agency costs are measurable. Data Set: The sam
AbstractThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muscles, a
IntroductionBeta-lactam antibiotics are essential in the treatment of Gram-negative bloodstream infections. The effect of beta-lactam antibiotics depends on the time of unbound antibiotic concentration above the minimal inhibitory concentration (MIC). An antibiotic concentration above MIC during the whole dosing interval (100% ƒT > MIC) has been suggested as a target for severe infections. The aim
This thesis examines how contrasting corporate digital strategies shape frontline hotel employees’ ability to balance chain-level systems with local service responsiveness. The study treats chain-level digital systems as contemporary fixed elements of hotel formats by applying and building up on the Integration-Responsiveness framework, Flexible Replication, and sociotechnical perspectives, in par
Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb pair with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard mode
(Neuro)psychiatric diagnoses such as attention deficit hyperactivity disorder (ADHD) is a rapidly growing and globally increasing phenomenon, not least in different educational contexts such as in family and in school. Children and youths labelled as ADHD are challenging normative claims in terms of nurturing and education, whereas those labelled as ADHD are considered a (future) risk for society (Neuro)psychiatric diagnoses such as attention deficit hyperactivity disorder (ADHD) is a rapidly growing and globally increasing phenomenon, not least in different educational contexts such as in family and in school. Children and youths labelled as ADHD are challenging normative claims in terms of nurturing and education, whereas those labelled as ADHD are considered a (future) risk for society
Ashbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. gossAshbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. goss
Based on the experience of the author and analyses of citation frequences of papers published in various biological journals, the use of citation counts and journal Impact Factors as a measure of scientific quality is discussed. It is concluded that citation frequency differ not only among biological sub-disciplines such as ecology and taxonomy, but also among taxonomic papers on highly similar toBased on my experience and analyses of citation frequencies of papers published in various biological journals, I discuss the use of citation counts and journal Impact Factors as measures of scientific quality. I conclude that citation frequency differs not only among biological sub-disciplines such as ecology and taxonomy, but also among taxonomic papers on highly similar topics, and that these l
In this study, the mechanical improvement of the platinum coated nanoporous gold is investigated by performing molecular dynamics simulations. The tensile properties of the structure is enhanced by a stress relief annealing which prevents the high stress concentration observed between the coating and the core materials. The annealing process is performed at 500K for 100ps with a heating and coolinIn this study, the mechanical improvement of the platinum coated nanoporous gold is investigated by performing molecular dynamics simulations. The tensile properties of the structure is enhanced by a stress relief annealing which prevents the high stress concentration observed between the coating and the core materials. The annealing process is performed at 500K for 100ps with a heating and coolin
Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several IAs against insulin, GAD65, or IA-2 (n =
The Tröger’s base framework has been implemented in two different receptors. The first of these receptors,incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional TheorThe Tröger’s base framework has been implemented in two different receptors. The first of these receptors, incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional Theo
A search for new charged massive gauge bosons, W′, is performed with the ATLAS detector at the LHC. Data were collected in proton–proton collisions at a center-of-mass energy of s=13 TeV and correspond to an integrated luminosity of 36.1 fb−1. This analysis searches for W′ bosons in the W′→tb¯ decay channel in final states with an electron or muon plus jets. The search covers resonance masses betw
We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War, based on a considerable body of contemporary sources. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for i
A vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperaturA vertical temperature stratification normally exists in rooms during the heat-ing season in cold climates. An expression of the gradient in apartments heated by hydronic radiator heating systems with exhaust ventilation has ear-lier been developed assuming a dependency of the outdoor temperature. The expression was used by a public real estate owner when re-calculating meas-ured indoor temperatur
