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The medically important drug target galectin-3 binds galactose-containing moieties on glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface-exposed binding site. All successful inhibitors of galectin-3 to date have been based on mono- or disaccharide cores closely resembling natural ligands. A detailed understanding of the H-bonding networks in these natural liganThe medically important drug target galectin-3 binds galactose-containing moieties on glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface-exposed binding site. All successful inhibitors of galectin-3 to date have been based on mono- or disaccharide cores closely resembling natural ligands. A detailed understanding of the H-bonding networks in these natural ligan

Radiopharmaceutical therapy is used to treat cancers and other diseases with radiolabeledpharmaceuticals. The treatment targets specific cells, and the emitted ionizing radiation cause cytotoxicdamage. Dosimetry is performed to estimate the absorbed dose from the energy deposited in the body.This requires measurement of the activity in vivo and knowledge of the retention time of the activity in tu Radiopharmaceutical therapy is used to treat cancers and other diseases with radiolabeled pharmaceuticals. The treatment targets specific cells, and the emitted ionizing radiation cause cytotoxic damage. Dosimetry is performed to estimate the absorbed dose from the energy deposited in the body. This requires measurement of the activity in vivo and knowledge of the retention time of the activity i

Healthcare organizations are challenged by complexity in structure and knowledge, and heterogeneity in deliveries and patient demands. Reductionist managerial approaches fall short in resolving the quality issues of healthcare, but Scientific Management and New Public Management (NPM) nevertheless has a strong hold on leadership thinking in hospitals. Increasing demand for adaptive and collaborati

The present compilation thesis is divided into two sections, one for each of two separate methodological issues: reduction of random errors in mortality estimates and offsetting random variation related bias in data generated estimators of risk inequalities. Summary of section A In regard to the first issue a new family of survival functions is proposed. Its purpose is to provide valid and reliabl

Financial accounting is a process that goes from the company’s transactions, through the accounting system and production of financial statements, to the use and analysis of the information by external parties. The analysis of financial statements is the basis for many important decisions. This book explains the fundamental role of financial accounting in the economy.The book covers both technical

It is not your fault – family counsellors work with sexually abused children and youth. Sexual abuse is a global phenomenon, occurring at every level of society. Previous studies show that victims often tell their stories about sexual abuse in a counselling setting. Family counsellors were chosen as respondents due to the fact that they work with different types of treatment and counselling and t

This thesis has as a purpose the investigation of sustainable requirements compliance with regards to competition in public procurement contracts. This paper looks into Directive 2014/24 and notably its primary law influence in order to understand the legal foundations underlying sustainability and competition. It showcases, firstly, that Article 18(1) wording and legal interpretation provides a l

According to the Federal Criminal Police Office, 139 women were killed by their (ex-)partner in 2020. That year, Germany was ranked second highest in estimated number of femicide victims in Europe. As most extreme form of gender-based violence, femicide or feminicide designate the gender-specific killing of women, related to the maintenance of hierarchical gender relations. The topic is little dis

The COVID-19 pandemic revealed the fragility of the global food system and its existing inadequacies in achieving food security, providing jobs, and ensuring environmental sustainability on various regimes around the world. Through a qualitative thematic-textual analysis, this thesis uses a case study of New York City to identify themes of actor expectations, either explicit or implicit, on how to

Oil is the most traded commodity in the world and is an important part in the global economy. The change in the price of oil has an effect on all sectors of the economy, and the ability to capture its risk is an important research topic. This study calculates the risk of one benchmark crude oil (West Texas Intermediate) over the period 1986-2015 by estimating the Value-at-Risk (VaR) and the Expect

The purpose of this thesis was to investigate the possibility of application of the cluster based rural development approach in Armenia to promote its structural transformation. Case study was selected as a research methodology, and both qualitative and quantitative methods were employed. Analysis of the key findings from the ‘field’, i.e. - the potential cluster, shows that rural households pract

This paper aims to discover viable ways in which the Global South can effectively challenge the primacy of the Global North, in order to create a more equitable global order. This thesis is premised on a dependency approach to international relations which stipulates that the Global South, or Third World, is underdeveloped because of actions by the Global North, or the First World. The legacy left

The establishment of the Internet and progression in computer science is connecting people at an alarming rate. Through these online connections an image-sharing culture has emerged. A prominent contributor to this social phenomenon is Facebook. Since Facebook launched its social networks in 2004, the popularity and growth of the platform has been phenomenal. It has become today’s dominant source

This chapter explores the role of placed-based relational entanglements in disasters and argues that relations play an important part in shaping how disasters unfold. Exploring the case of mining-induced displacement in Sweden’s Malmfälten region—where two cities, Kiruna and Malmberget, and several villages are being moved or razed to make way for expanding mines—the chapter demonstrates how a str

In order to manage the image of a city in a highly medialized world it is important that the key features of the brand is correlating with the overall media image. This paper exams the impact of Malmö Stads vision-report in the media portrayal of the city between 1997-2012. The aim is to describe, explain and problematize the media image of Malmö in the biggest swedish publications and compare tha