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Moving on to work and feeling better-A randomised controlled trial of supported employment adapted for people with affective disorders.
What Happens to Nordic Culture When you Drop the “Heritage"? : Re-imagining Nordic culture for a new museum
AbstractSeattle is currently the fastest growing city in the United States attracting a large pool of young international professionals – many of whom are working in the IT industry. However, Seattle is also home to a large Nordic community, immigrants once attracted by the agricultural, forestry, and fishing industries. At present however, the city is pulling in a highly educated young Nordic pop
Evidence of effect and exposure-response functions for PM2.5 and NO2 linked to morbidity
Health impact assessments (HIA) have largely focused on mortality; this report, therefore, examines and evaluates which morbidity impacts are appropriate to include in HIAs. The task was assigned by Swedish Environmental Protection Agency (EPA), and the original report (written in Swedish) was performed by Anna Oudin (AO), Erin Flanagan (EF), and Ebba Malmqvist (EM). The original report also inclu
Embedding and Integrating a Digital Patient Management Platform Into Everyday Primary Care Routines: Qualitative Case Study
Background:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care c
Strandskyddet - de nya reglerna och möjligheterna till dispens
The shore protection has in Sweden been statutory regulated since 1950. Since then it has been extended and developed, as the awareness of the importance for preservation of unexploited land along the shores has grown. The earlier legislation focused entirely on human’s access to the shores and the surroundings near the shores, for recreation and extracurricular activities. The terms for, and pres
Getting at the Experience of Confinement in Detention
A distinguishing feature of youth detention homes—and any other prisonlike institution—is the fact that inmates cannot just leave. They might escape, and there are ways to be transferred, enjoy an excursion, and get permission for home visits, but typically the young people in this case are supposed to remain within their given institution. I have been eager to not only depict this feature of fiel
Annual direct medical cost of active systemic lupus erythematosus in five European countries
Objectives To evaluate the annual direct medical cost of managing adult systemic lupus erythematosus (SLE) patients with active autoantibody positive disease in Europe. Methods A 2-year, retrospective, multicentre, observational study was conducted in five countries (France, Germany, Italy, Spain and the UK). Data included patients' characteristics, disease activity and severity, flare assessments
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AI Lund lunch seminar: The Agreeable AI – How LLMs Personalise Political Bias Through Moral Alignment
AI Lund lunch seminar: The Agreeable AI – How LLMs Personalise Political Bias Through Moral Alignment
Sverker Sikströms publications
Hamade, Jaber, Sikström, S. (2009). Analyzing CAD competence with univariate and multivariate learning curve models. Computers & Industrial Engineering, 56, 1510-1518.Lind, A., Hall, L, Johansson, P., Sikström, S (in press). Can we tell what we said when we hear ourselves saying something else? . Bringing language and cognition back together again. Editors Jordan Zlatev, Mats Andrén, Marlene Johan
https://www.psy.lu.se/sverker-sikstroms-publications - 2026-05-15
IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection
Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat
Development and validation of a machine learning-based model to predict isolated post-challenge hyperglycemia in middle-aged and elder adults : Analysis from a multicentric study
Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a
Resting-State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response : A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy
Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder
Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h
Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes
Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven
Cultured Mast Cells from Patients with Asthma and Controls Respond with Similar Sensitivity to Recombinant Der P2-Induced, IgE-Mediated Activation
The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir
A Simulation Study Quantifying the Effects of Drive Cycle Characteristics on the Performance of a Pneumatic Hybrid Bus
In the study presented in this paper, the effect of different vehicle driving cycles on the pneumatic hybrid has been investigated. The pneumatic hybrid powertrain has been modeled in UT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been c
Mode of Coreceptor Use by R5 HIV Type 1 Correlates with Disease Stage: A Study of Paired Plasma and Cerebrospinal Fluid Isolates.
Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme
