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Sex differences in age-dependent mortality and reproductive success are predicted to drive the evolution of sexually dimorphic patterns of reproductive investment over life. However, this prediction has not been fully explored because it is difficult to measure primary and secondary sexual traits over the life spans of males and females. Here we studied a population of fowl, Gallus gallus, to gain
In this article we present a spatio-temporal dynamic model that can be realized using image warping. Image warping is a non-linear deformation which maps every point in one image plane to a point in another image plane. Using thin-plate splines, these deformations are defined by how a small set of points is mapped, making the method computationally tractable. In our case the dynamics of the proces
Background We have previously reported that asthma differs from rhinitis with or without bronchial hyperresponsiveness in the perception and degree of lower airway inflammation. Objective The aim of the present study was to investigate whether sputum levels of inflammatory markers could further distinguish these patient groups. Methods Patients with seasonal allergic rhinitis with or without asthm
Objective The aim of this study was to evaluate transvaginal sonograpbic assessment of cervical length at 23 weeks as a screening test for spontaneous preterm delivery in order to define a cut-off value that could be used to select twin pregnancies at low risk of spontaneous preterm delivery. Methods In a prospective multicenter study of 383 twin pregnancies included before 14 + 6 weeks a cervical
A consecutive series of patients with all types of cervical hip fracture (both undisplaced and displaced) were randomised to osteosynthesis with Hansson hook-pins (n = 98) or AO-screws (n = 101). Background parameters, fracture type and reduction of the fracture did not differ significantly between the groups. Fifty-seven percent of the patients were operated on within 6 h of admission to hospital
Patients with acute asthma attending the emergency room were included in a double-blind, double-dummy and parallel group study to investigate whether a dry powder inhaler (Turbuhaler) can be used in acute asthma. If so, the aim was to establish the potency relationship between a beta 2-agonist (salbutamol) administered by the dry powder inhaler and the pressurized metered-dose inhaler (pMDI). Eigh
Popular Abstract in Swedish El-avfall (avfall från elektriska och elektroniska produkter) har under det senaste årtiondet blivit ett växande miljöproblem också i de mindre rika länderna (icke-OECD länder). Informell återvinning i u-länder har lett till att giftiga ämnen, som t.ex. bly och kvicksilver från tv-apparater, PVC från sladdar och bromerade flamskyddsmedel från plastkomponenter, har läcktWaste electrical and electronic equipment (WEEE) has become a salient issue in non-OECD countries. With a growing awareness about serious damages to the environment and human health from a lack of safe treatment and recycling of WEEE, there has been a search for policy responses in several of these countries. This research finds that extended producer responsibility (EPR), a policy principle that
Economical grade changes are considered for a Borealis Borstar polyethylene plant model, incorporating two slurry-phase reactors, one gas-phase reactor and a recycle area with three distillation columns. The model is constructed in the Modelica language and the JModelica.org platform is used for opti- mization. The cost function expresses the economical profit during a grade change and is formulat
Syftet med denna uppsats är att undersöka hur våldtäktsbrottet har förändrats i lagstiftningen under de senaste 100 åren. Jag börjar med att beskriva gällande rätt i 1864 års strafflag, och går sedan igenom de reformer som gjorts av våldtäktsbrottet i brottsbalken fram till vad som stadgas idag i den så kallade samtyckeslagen. Jag beskriver hur lagstiftaren har motiverat sina reformer av brottet oThe purpose of this essay is to investigate how the offence of rape has developed in the swedish legislation during the last century. The essay first contains a discription of the offence as stipulated in the criminal law from 1864. I thereafter describe all the reforms of the offence that have been made in the Penal Code until 2018, which is the applicable law today. What the governments intentio
Begreppet rättssäkerhet används ofta både inom och utom den rättsvetenskapliga sfären. Eftersom man inte sällan möter det i den allmänna debatten i Sverige, syftar den här uppsatsen till att undersöka om begreppet i det sammanhanget används i samma betydelse som inom rättsvetenskapen. Undersökningen tar avstamp i vad framstående svenska rättsvetare har uttryckt ifråga om att definiera begreppet rThe Swedish equivalent of the term “the rule of law”, namely “rättssäkerhet”, is widely used both within and outside of the sphere of legal research. Since it is often seen in the Swedish public debate, this essay aims to examine whether the term is used in the same denotation in this context, as it is within the context of legal studies. This examination starts off by compiling and collating wha
We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case–control subset
Background: The standard reference region (RR) for amyloid-beta (Aβ) PET studies is the cerebellar grey matter (GMCB), while alternative RRs have mostly been utilized without prior validation against the gold standard. This study compared five commonly used RRs to gold standard plasma input-based quantification using the GMCB. Methods: Thirteen subjects from a test–retest (TRT) study and 30 from a
The management system presented in the paper allows the generation and control of documentation flow throughout the whole manufacturing process, from all design levels to manufacturing. Using the method of quality assurance, a useful management system has been developed that covers cooperative work between different departments, clear responsibilities, the description of procedures for documentati
Background: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. Methods: We harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of car
We present an algorithm, called Bonsai, for rapidly building bounding volume hierarchies for ray tracing. Our method starts by computing midpoints of the triangle bounding boxes and then performs a rough hierarchical top-down split using the midpoints, creating triangle groups with tight bounding boxes. For each triangle group, a mini tree is built using an improved sweep SAH method. Once all mini
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last decade. In the study of cancer, the CRISPR/CRISPR-associated protein (Cas) system opens new avenues into issues that were once unknown in our knowledge of the noncoding genome, tumor heterogeneity, and pr
Background: Violence due to firearms is a major global public health issue and vascular injuries from firearms are particularly lethal. The aim of this study was to analyse population-based epidemiology of firearm-related vascular injuries. Methods: This was a retrospective nationwide epidemiological study including all patients with firearm injuries from the national Swedish Trauma Registry (SweT
Background: In patients with chronic obstructive pulmonary disease (COPD), the relationship between short-term bronchodilator reversibility and longer-term response to bronchodilators is unclear. Here, we investigated whether the efficacy of long-acting bronchodilators is associated with reversibility of airflow limitation in patients with COPD with a low exacerbation risk not receiving inhaled co
IntroductionAn important hallmark of cancer is escaping the immune system. Despite advances in immunotherapy, only a subset of patients experiences clinical benefits. It was shown that adoptive T cell or checkpoint inhibition therapy rely on the presence of conventional dendritic cells type 1 (cDC1). cDC1 excel in recruiting and priming protective CD8+ T cells through cross-presentation. However,
