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The gram-positive, endospore-forming bacterium Bacillus subtilis contains several membrane-bound c-type cytochromes. We have isolated a mutant pleiotropically deficient in cytochromes c. The responsible mutation resides in a gene which we have named ccdA (cytochrome c defective). This gene is located at 173 degrees on the B. subtilis chromosome. The ccdA gene was found to be specifically required

Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform genome-wide association study scans for these five types and two combined groups. Our results show associated variants in all scans. Inguinal hernia has the most associations and we

We provide evidence of a positive effect of major infrastructure development on international trade, using the opening of the fixed link between Denmark and Sweden in 2000 (The Oresund Bridge) as a quasi-natural experiment. Our Synthetic Control Method (SCM) constructs a counterfactual Danish-Swedish trade relationship, which represents bilateral trade in the absence of the bridge. Evaluating actu

The goal of our research is the construction of efficient Jacobian-free preconditioners for high order Discontinuous Galerkin (DG) discretizations with implicit time integration. We are motivated by three-dimensional unsteady compressible flow applications, which often result in large stiff systems. Implicit time integrators overcome the impact upon restrictive CFL conditions on explicit ones but

We study the scaling properties of the differential cross section of elastic proton–proton (pp) and proton–antiproton (pp¯) collisions at high energies. We introduce a new scaling function, that scales – within the experimental errors – all the ISR data on elastic pp scattering from s=23.5–62.5 GeV to the same universal curve. We explore the scaling properties of the differential cross-sections of

Linear response theory for the multiconfigurational short-range density functional theory (MC-srDFT) model is extended to triplet response with a singlet reference wave function. The triplet linear response equations for MC-srDFT are derived for a general hybrid srGGA functional and implemented in the Dalton program. Triplet excitation energies are benchmarked against the CC3 model of coupled clus

This paper describes an algorithm for reconstructing and identifying a highly collimated hadronically decaying τ-lepton pair with low transverse momentum. When two τ-leptons are highly collimated, their visible decay products might overlap, degrading the reconstruction performance for each of the τ-leptons. A dedicated treatment attempting to tag the τ-lepton pair as a single object is required. T

OBJECTIVE:: Early postoperative pain correlates to persisting pain, psychosocial distress, and delayed mobilization with thromboembolic and infectious complications. Electrical pain thresholds (EPT) have shown promising results in being able to predict postoperative pain, but the results are conflicting. The aim of this study was to test whether EPT levels can be used to predict postoperative pain

BACKGROUND Ixazomib is an oral proteasome inhibitor that is currently being studied for the treatment of multiple myeloma. METHODS In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 722 patients who had relapsed, refractory, or relapsed and refractory multiple myeloma to receive ixazomib plus lenalidomide-dexamethasone (ixazomib group) or placebo plus lenalidomide-dexame

Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical d

This study explores the extent to which decentralization has affected farmers’ access to agricultural advisory services in the Sunyani Municipality of Ghana. Specifically, it focuses on how political and organizational factors, which are intermediate outcomes of decentralization, affect the availability and relevance of advisory services. The study follows a qualitative research design employing q

The purpose of this study was to psychometrically test a Swedish translation of The Shame Inventory, originally developed by Rizvi (2010). Another purpose was to investigate the link between shame and psychopathology and specifically to borderline personality disorder. The psychometric properties of the Swedish version of The Shame Inventory were investigated, as well as the ability of the instrum

Med utgångspunkt i unionsrättslig praxis syftar arbetet att undersöka ompaketeringsundantagets innebörd och dess tillämpning i svenska domstolar. Inledningsvis ges en allmän beskrivning av parallellimport och läkemedelsmarknaden och därefter undersöks etablerandet av ompaketeringsundantaget och dess innebörd. EUD har fastställt att även om fördraget inte berör förekomsten av immateriella rättigheThis essay investigates the trade mark doctrine for parallel importation of repackaged pharmaceuticals established in community law, and how this doctrine is applied in Swedish courts. Initially the author generally describes parallel imports and the pharmaceutical market before investigating the establishment of the doctrine and its meaning. The ECJ have established that whilst the treaty does n