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Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative
Amyloid protein deposits are the hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, or diabetes type II. Although their connection to the diseases is not fully understood, many studies point at intermediate species called oligomers as being the main responsible for the toxicity of these proteins. This makes them strong candidates as therapeutic targets. However, due to their
Vapor–solid–solid (VSS) growth of III-V semiconductor nanowires (NWs) has long been considered an alternative for the vapor–liquid–solid (VLS) growth mode, with the potential to avoid the incorporation of deep-level impurities into semiconductors and to form compositionally abrupt interfaces. Most research however indicates that VSS growth has a much lower growth rate than observed in the VLS grow
Introduction: Teledermatoscopy (TDS) has proven to be effective and reliable for diagnosis of skin malignancies. The factors that determine the success of implementation of TDS are largely unknown. Objectives: To investigate barriers to implementation of TDS in primary health care (PHC) at center and individual level. Methods: Following introduction of TDS, cross-sectional quantitative data and fr
Numerous neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis share a neuropathological hallmark: aberrant protein aggregation in the CNS. Microglia, the brain's innate immune cells, also play a pivotal role in the pathogenesis of these disorders. Multiple studies indicate that these pathological aggregates can propagate throughout the brain
In this work, we focus on the computational bridging between the meso- and macro-scale in the context of the hybrid modelling of Internal Traverse Grinding with electro-plated cBN wheels. This grinding process satisfies the manufacturing industry demands for a high rate of material removal along with a high surface quality while minimising the number of manufacturing processes invoked. To overcome
Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.
Out-of-pocket (OOP) expenditures for childbirth in Bangladesh have increased substantially, intensifying financial pressure on lower-income households. While wealthier groups historically bore higher delivery costs, recent trends indicate a narrowing gap in spending across socioeconomic strata. This study investigates the drivers of this convergence in delivery-related expenditures between 2014 an
The Colombian Peace Agreement signed in 2016 was saluted internationally by scholars, policy makers and practitioners for encompassing the concept of territorial peace as a means of ensuring local participation in the strengthening of state institutions. Based on engaged research conducted in the Department of Cauca and Bogotá between 2017 and 2020, we critically analyse territorial peace, explori
We explored possible differences in the peripheral and central pharmacokinetics of L-DOPA as a basis for individual variation in the liability to dyskinesia. Unilaterally, 6-hydroxydopamine (6-OHDA) lesioned rats were treated chronically with L-DOPA for an induction and monitoring of abnormal involuntary movements (AIMs). Comparisons between dyskinetic and non-dyskinetic cases were then carried ou
The formation of TiO2 films on clean and pre-oxidized Si(1 1 1) through chemical vapor deposition of titanium(IV) isopropoxide (TTIP) in ultra-high vacuum has been examined by synchrotron radiation photoelectron spectroscopy, X-ray absorption spectroscopy (XAS) and scanning tunneling microscopy. In both cases, TTIP deposition at 500 °C eventually results in an anatase TiO2 film with a carbon-free
In the fourth century B.C., Athenians were often accused of avoiding their civic obligations and of concealing their wealth.1 These attested cases show that economic behaviour in classical Athens could be affected by taxation. The purpose of the present study is to systematically explore the economic incentives resulting from the taxation of wealth. The first issue is the effects of the property t
Disturbed indoor climate may in some cases be associated with illness. In the present paper, we report the results from a thorough investigation of office workers in Greenland, who developed skin and/or airway problems after moving into renewed offices.
1 This study examines the importance of mitogen-activated protein kinases (MAPKs) in upregulation of endothelin type B (ETB) receptors. 2 Rat middle cerebral arteries (MCAs) were incubated for 24 h with or without kinase inhibitors. Vessel segments were mounted in myographs and the contractile responses to endothelin-1 (ET-1; ETA and ETB receptor agonist) and sarafotoxin 6c (S6c; ETB receptor agon
Polyamines are essential polycations involved in a large variety of biological functions, including modulation of the nucleic acid conformation, RNA export and their degradation, protein synthesis, eIF-5A posttranslational modification, signal transduction, cell growth and differentiation, and tumor progression ( 1 –bi3. These various aspects in the biology of polyamines are addressed in other sec
Derived from the renowned multi-volume International Encyclopaedia of Laws, this practical analysis of the law of contracts in Sweden covers every aspect of the subject – definition and classification of contracts, contractual liability, relation to the law of property, good faith, burden of proof, defects, penalty clauses, arbitration clauses, remedies in case of non-performance, damages, power o
