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Perilipin 1 is a lipid droplet coating protein known to regulate lipid metabolism in adipocytes by serving as a physical barrier as well as a recruitment site for lipases to the lipid droplet. Phosphorylation of perilipin 1 by protein kinase A rapidly initiates lipolysis, but the detailed mechanism on how perilipin 1 controls lipolysis is unknown. Here, we identify specific lipid binding propertie
A Bayesian assessment of the probability that the defendant in a criminal trial is guilty depends on the presumed base rate for guilt and the estimated likelihoods of the evidence. This article explores how the base rate shall be determined. Bayesian scholars have recommended a base rate of 1/N, where N is the number of ‘possible perpetrators’, but it is unclear how the reference class of possible
Importance: Twin studies have assessed sibling resemblance for major depression (MD) but cannot address sources of resemblance across generations. Objective: To clarify the relative importance of genetic and rearing effects on the parent-offspring resemblance for MD. Design: This Swedish population register-based study examined parents and children from the following 5 family types: intact (2 041
BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP).METHODS: An incepti
The present article argues that the fact that personal data holds great value, in combination with a lack of transparency in its commercial use, leads to a need for consumer policy that strengthens consumer protection. The widespread practice of user agreements and consent-based regulation of personal data collection is not satisfactory for balancing these information-asymmetric markets. The lack
Objectives: Using a reversible multistate model, we prospectively examined neuropsychiatric (NP) events for attribution, outcome and association with health-related quality of life (HRQoL), in an international, inception cohort of systemic lupus erythematosus (SLE) patients. Methods: Annual assessments for 19 NP events attributed to SLE and non-SLE causes, physician determination of outcome and pa
During corrosive dissolution of metal ions from a body surface, an oxide compound isproduced. This compound forms a protective film that reduces the dissolution rate. When afraction of a millimetre depth is dissolved the dissolution rate become insignificant. However,repeated loading will damage the film with continued dissolution as a result. In connectionwith this a threshold strain is assumed t
BACKGROUND: Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo pathway, a signal transduction system implicated in tissue repair and regeneration, as well as tumorigenesis. Here we evaluate the biomarker potential
Moth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct rMoth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct reflec
The relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performanceThe relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performance
BACKGROUND—: The cumulative burden and importance of cardiovascular risk factors have changed over the last decades. Specifically, obesity rates have increased among younger people, whereas cardiovascular health has improved in the elderly. Little is known regarding how these changes have impacted the incidence and the mortality rates of heart failure. Therefore, we aimed to investigate the age-sp
Interdisciplinary research in the fields of forestry and sustainability studies often encounters seemingly incompatible ontological assumptions deriving from natural and social sciences. The perceived incompatibilities might emerge from the epistemological and ontological claims of the theories or models directly employed in the interdisciplinary collaboration, or they might be created by other ep
Measures of muscle mass, strength, and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX (fracture risk assessment tool) probability. In the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, United States), we investigated whether measures of physical performance/appendicular lean mass (ALM) by DXA pred
IMPORTANCE Heart failure (HF) aggregates in families, but the heritability of HF has not been determined. Discerning the genetic and environmental contributions to HF risk is important to further helping to identify individuals at risk. Adoption studies may establish the genetic contribution to HF. OBJECTIVE This nationwide adoption study aimed to determine the heritability of HF. DESIGN, SETTING,
The presence of graphite particles in gray cast iron commonly implies a good machinability, especially if compared to common steels. However, increasing industrial demands have resulted in a new interest for high-speed machining of these materials with higher performing tool materials than the traditionally used. Thus, the research presented in this paper focuses on evaluating the active tool wear
AIMS: The CHA2DS2VASc score is used to evaluate the risk of thromboembolic events in patients with non-valvular atrial fibrillation. We assessed the prognostic yield of CHA2DS2VASc for new-onset atrial fibrillation, cardiovascular morbidity and mortality in a non-atrial fibrillation population.METHODS: We analysed a population-based cohort of 22,179 middle-aged individuals with (n = 3542) and with
Vad hände med innebörden av ordet "otrygghet", ett ord med gamla svenska rötter och en tidigare etablerad innebörd, när det amerikanska forskningsfältet "Fear of Crime" introducerade i Sverige och översattes till "Otrygghet"? Syftet med denna avhandling är att beskriva trygghetsforskningens uppkomst, etablering och expansion i Sverige, i syfte att besvara frågor om forskningsdiskursens funktion, sThe purpose of this dissertation is to construct an historical account of the emergence, establishment, and expansion of fear of crime research in Sweden. This dissertation aims to answer questions about the function, spread, and high level of institutional engagement of fear of crime research by analyzing the literature and examining the methodological, theoretical, and epistemological origins of
In recent years, a dispute has arisen within detection and attribution science concerning the appropriate methodology for associating individual weather events with anthropogenic climate change. In recent contributions, it has been highlighted that this conflict is seemingly misconstrued even by those participating in it and actually concerns a mixture of first and second order so-called inductive
