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No Trouble Found (NTF) has been discussed for several years [1]. An NTF occurs when a device fails at the board/system level and that failure cannot be confirm by the component supplier. There are several explanations for why NTFs occur, including: device complexity; inability to create system level hardware/software transactions which uncover hard to find defects; different environments during te

A three second window has long been suggested by Pöppel (2009) and others, to guide the human perception. More recently,a three second constant has been suggested in overt human behaviour (Schleidt, 1988) as well as in mammalian species in general (Gerstner & Goldberg, 1994). It is however unclear whether this temporal window exists in other vertebrate species. This study examines the existenc

Titel: Marknadens leoparder - om first mover advantage och betydelsen av att vara först Seminariedatum: 30 maj 2012 Kurs: FEKN90, Examensarbete i företagsekonomi på magisternivå, 30 högskolepoäng. Författare: Victor Bengtsson & Mikael Falk Handledare: Matts Kärreman Fem nyckelord: First Mover Advantage, Red Queen, Konkurrensfördelar, Leoparder, Marknadsledare. Syfte: Syftet med studien Title: The Leopards of The Market - on First Mover Advantage and The Importance of Being First Seminar date: May 30th, 2012 Course: Master thesis in business administration, 30 University Credit Points (30 ECTS) Authors: Victor Bengtsson & Mikael Falk Advisor/s: Matts Kärreman Five key words: First Mover Advantage, Red Queen, Competitive Advantages, Leopards, Market Leadership. Purpose:

I samband med kommersiella avtalsförhandlingar upprättas många olika förhandlingsdokument. Parterna kan skriva sekretessavtal, letters of intent, aktieägaravtal, anställningsavtal och överlåtelseavtal – för att nämna några. Under förhandlingarnas gång skickas många förhandlingsbud och åtskilliga avtalsförslag, avseende det slutliga överlåtelseavtalet, mellan parterna. Ett letter of intent bringaIn a contract negotiation a variety of negotiation documents are created. The parties may sign confidentiality agreements, letters of intent, shareholder agreements, employment agreements and transfer agreements – to name a few. During negotiations, many offers and proposals regarding the final transfer agreement are exchanged between the parties. A letter of intent brings order and clarity in a

Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The

To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using

The epithelial cell adhesion molecule gene (EPCAM, previously known as TACSTD1 or TROP1) encodes a membrane-bound protein that is localized to the basolateral membrane of epithelial cells and is overexpressed in some tumors. Biallelic mutations in EPCAM cause congenital tufting enteropathy (CTE), which is a rare chronic diarrheal disorder presenting in infancy. Monoallelic deletions of the 3′ end

Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the U

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These s

Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th

Background: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. We studied if daylight length was associated with glycemic traits and if it modified the relationship

Probing the dynamic control features of biological networks represents a new frontier in capturing the dysregulated pathways in complex diseases. Here, using patient samples obtained from a pancreatic islet transplantation program, we constructed a tissue-specific gene regulatory network and used the control centrality (Cc) concept to identify the high control centrality (HiCc) pathways, which mig

Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This po

The Precision Medicine Initiative defines precision medicine as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person." This approach will facilitate more accurate treatment and prevention strategies in contrast to a one-size-fits-all approach, in which disease treatment and prevention strategi

Objective: The capacity to precisely predict progression to type 1 diabetes (T1D) in young children over a short time span is an unmet need. We sought to develop a risk algorithm to predict progression in children with high-risk human leukocyte antigen (HLA) genes followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: Logistic regression and 4-fold cross-valida

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy — dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) — have overlapping clinical and pathologica

In type 1 diabetes, pancreatic beta cells are destroyed by chronic autoimmune responses. The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infections have long been considered as candidates for environmental triggers but, given the lack of evidence for an acute, widespread, cytopathic effect in the pancreas in type 1 diabet