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Aims/hypothesis: We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods: We used a risk set sampled nested case–c

Complement is a key first line innate host defense system in the blood of vertebrates. Upon activation, this powerful defense mechanism can elicit inflammatory responses, lyse non-self-cells, or mark them for opsonophagocytic removal. Blood-feeding arthropods thus require the ability to block host complement activation in the bloodmeal to prevent undesired cell or tissue damage during feeding. The

PURPOSE: Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns' risk of NCDs may provide approaches to prevent NCDs.PARTICIPANTS: The FOETALforNCD (FOetal Exposure and Epidemiological Transitions: the role of Anaem

Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed for this work. We review the possibilities and limitations of currently available human beta cell models and how they can be dramatically enhanced using genome-editing technologies

Narcolepsy type 1 (NT1) is a neurological sleep disorder. The biological cause is the degeneration of hypocretin neurons located in the hypothalamus. It has been suggested that NT1 has an autoimmune pathogenesis, as in most patients, the Human Leukocyte Antigen (HLA)-DQB1*06:02:01 is present. An increased incidence of NT1 was observed in Sweden following the 2009 influenza Pandemrix®-vaccination.

T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. This model has become almost a

OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific differences associated with type 1 diabetes. Because age is a primary driver of heterogeneity in type 1 diabetes, we sought to characterize by age metabolic derangements prior to diagnosis and clinical features associated with diabetic ketoacidosis (DKA). RESEARCH DESIG

AIM: We aimed to examine the effect of Ramadan fasting on interstitial glucose control and variability before, during, and after Ramadan in type 2 diabetes patients receiving insulin therapy.METHODS: Participants received a flash glucose monitoring (FGM) system one week before Ramadan that was removed on the sixth or seventh day (pre- and early Ramadan periods) of Ramadan and a second FGM system o

The etiology of type 1 diabetes foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of type 1 diabetes. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) and ZnT8 transporter (ZnT8A) allowed children to be followed from birth until the appearance of a first islet auto

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-ev

Background: We aimed to investigate if early life marine n-3 fatty acids and fish intake, and fatty acid desaturase (FADS) genetic variants, were associated with later risk of celiac disease (CeD).Methods: Among 85,244 children in the prospective Norwegian Mother, Father, and Child Cohort Study, fish and marine fatty acid intakes were estimated from questionnaires to mothers during pregnancy, and

Background Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. The aim of the Primary Oral Insulin Trial (POInT) was to evaluate the efficacy and safety of daily high-dose oral insulin to prevent the development of islet autoantibodies and diabetes. Methods In this randomised, controlled, primary prevention trial, genetic screening in seven obstetric and

Ozonation is one of the most promising advanced oxidation processes to be implemented as quaternary treatment for the removal of micropollutants in wastewater treatment plants. However, there are some knowledge gaps that limit its implementation. First, the removal efficiency is not known for all pollutants, and second, knowledge about degradation byproducts is limited, as well as the toxicity of

BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M

PowerPoint-presentation Centrum för miljö- och klimatforskning, CEC Centrum för miljö- och klimatforskning, CEC, är en kombinerad fysisk och virtuell centrumbildning vid Naturvetenskapliga fakulteten på Lunds universitet. CEC bedriver forskning, utbildning och kommunikation om miljö- och klimatrelaterade frågor. 1 VISITING ADDRESS The Ecology building Sölvegatan 37 in Lund CECs verksamhet befinner

https://www.cec.lu.se/sites/cec.lu.se/files/lu_cec_2018_4-3_svenska_med_film_0.pptx - 2026-06-04

RESEARCH IN SERVICE STUDIES LUND UNIVERSITY, Campus Helsingborg Working paper No 5, May 2011 The Department of Service Management The waste hierarchy model: disassembling and reassembling the socio-materiality of waste Johan Hultman and Hervé Corvellec Abstract The production of waste is a central concern for environmental policy, and waste management is a critical urban infrastructural service. T

https://www.ses.lu.se/sites/ses.lu.se/files/oki-wp_5_2011.pdf - 2026-06-04