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In this paper we model the criminal standard of proof as a twofold standard requiring sufficient probability of the factum probandum and sufficient informativeness. The focus of the paper is on the latter requirement, and we use decision theory to develop a model for sufficient informativeness. We demonstrate that sufficient informativeness is fundamentally a question of information economics and

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 who

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome dat

The differential cross section of inelastic electron scattering for the low-lying “collective” Kπ=1+ excitations in rare-earth nuclei is calculated in DWBA by using microscopically calculated transition-densities. In the region of low-momentum transfer (q⪅0.5 fm-1) in which experimental data are available the shape of calcualted cross sections is almost the same for all nuclei and is slightly but

Surfactant-templated materials are created through self-assembly in solutions containing both surfactant micelles and an inorganic species. The resulting materials are composites containing an organized surfactant micelle array encapsulated in the inorganic material. Removal of the surfactants generates nanoscale pores which replicate the highly organized micelle phase, producing high surface area

OBJECTIVE: To identify and genetically characterize subgroups of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on sex and ANCA subtype.METHODS: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for ass

Although Benjamin Schnieder’s theory of the “ordinary conception” of properties successfully handles paradoxical properties—particularly, the property of non-self-instantiation—it fails to account for ordinary, non-pathological cases. The theory allows the inference of ‘a has the property of being F’ only given F(a) and the prior assertibility of ‘the property of being F can exist’. While this all

Known as the winner of the 2020 Man Booker Prize, Douglas Stuart’s debut novel Shuggie Bain evokes childhood queerness, which is entangled in the deindustrialised urban landscape of 1980s Glasgow. Synthesising queer and trace theory in nine steps—disruption, bent temporality, materiality and embodiment, physical orientation, medium specificity, reading and bearing traces, involuntariness and the l

The finite element model was successfully applied to predict the Pb-210 and total extractable fatty acid concentrations at different depths in two sediment cores from Lake Ontario by using different transport parameters. The transport parameters were computed from Pb-210 data. These parameters were used to simulate the total extractable fatty acid concentrations at different depths. The computed r

This paper inspects the territorial and state restructuring of the globalising city-region of Tangier. It argues that recent economic growth and transnational connections follow new forms of entrepreneurial development that aggravate social and spatial inequalities. The analysis shows that these forms of urban and regional management are embedded in the neoliberalised, yet monarch-centric Moroccan

I contribute to an emerging politics of loss through an empirical analysis of temporalities of climate change loss and damage in Australia. How people temporalize climate change informs their conception of causality, designation of losses and damages, and political response. By drawing attention to the diversity of onto-epistemological understandings and characterizations of climate change loss an

Diffusion of water through membranes presents a considerable challenge, as the diffusivity often depends on the local concentration of water. One particular example with strong biological relevance is the stratum corneum (SC) as the primary permeability barrier for the skin. A simple alternative for the constant diffusivity model is provided by the Fujita’s two-parameter rational approximation, wh

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incor