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MicroRNAs (miRNAs) are key players in the regulation of neuronal processes by targeting a large network of target messenger RNAs (mRNAs). However, the identity and function of mRNAs targeted by miRNAs in specific cells of the brain are largely unknown. Here, we established an adeno-associated viral vector (AAV)-based neuron-specific Argonaute2:GFP-RNA immunoprecipitation followed by high-throughpu

Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms c

The core level photoemission and near edge X-ray photoabsorption spectra of guanine in the gas phase have been measured and the results interpreted with the aid of high level ab initio calculations. Tautomers are clearly identified spectroscopically, and their relative free energies and Boltzmann populations at the temperature of the experiment (600 K) have been calculated and compared with the ex

The increasing size of the population results in that unbuilt spaces needing to be used for the construction of new facilities. Large construction sites can generate disturbing vibrations to nearby buildings, both while construction is underway and afterwards through the operation of subways, for example. The establishment of new areas close to, for example, motorways and railways increases the ri

During recent years, Geographic Information Systems (GIS) as a powerful tool have had a tremendous impact on research techniques in the realm of geography and spatial analysis. The integrative ability of GIS to capture, store, manipulate, analyze, manage, and finally present all types of geographical spatial data, has drawn many attentions to it. Water Resources Engineering as a interdisciplinary

The aim of this article is to describe and analyse the working conditions of interpreters and interpreting services in Sweden. An understanding of interpreters' working conditions is a key to such factors as the management of resources, the reading and implementation of legislation, the organisation of interpreting services and the performance of interpreters in different situations. An understand

Extended shelf-life milk can be produced by a combination of microfiltration and pasteurisation. However, due to the need for high cross-flow velocity during microfiltration, the energy consumption is high. One way of decreasing the energy demand during microfiltration is to use back-pulsing for fouling control. Microfiltration was performed in constant flux mode on skim milk to measure the foulin

This study reports increasing iron concentrations in rivers draining into the Baltic Sea. Given the decisive role of iron to the structure and biogeochemical function of aquatic ecosystems, this trend is likely one with far reaching consequences to the receiving system. What those consequences may be depends on the fate of the iron in estuarine mixing. We here assess the stability of riverine iron

The study will be focusing specifically on the impacts that these entrepreneurs have had on the UK (regional) economy. In the last 20 years we have seen a wealth of studies analyzing the determinants of entrepreneurship. Though some of these studies are theoretical (e.g. Holmes and Schmitz, 1990), others are empirical (e.g. Evans and Leighton, 1990). The impacts of entrepreneurship, in terms of ec

The goal with this master thesis is to examine the usability in the Tetra PlantMaster. Tetra PlantMaster is the control system for the dairies that Tetra Pak develops. Tetra PlantMaster is the system which the operator uses in order to govern the entire process when raw milk becomes a product ready to be delivered to the grocery stores. This includes applications to produce soured milk, yoghurt, i

The study raises the question how (if at all) relations with university affect the innovativeness of new media firms in Skåne and to what extent it can be related to the type of knowledge base. The object of the analysis is 36 new media companies in the region. The data was selected using the methods of structured and semi-structured interviews. Open Innovation paradigm, knowledge base and knowled

This study investigates how the debt levels of firms belonging to the Nordic market change over time and what determines these changes. We find that contemporaneous changes in leverage are mainly determined by profitability, market timing, leverage deficits (deviations from target leverage) and changes in targets. We find two factors whose effects persist for at least ten years, namely profitabili

The purpose of this thesis is to test the implications of the permanent income – life cycle hypothesis. According to Hall (1978), if the permanent income-life cycle hypothesis is valid, consumption should follow a random walk and no variable other than once-lagged consumption should help explaining current consumption. Two different tests are conducted. Firstly, consumption is regressed upon its o

The one-step conversion of unprotected sugars to sugar intermediates invented by the Shin-ichiro Shoda group at Tohoku University in Japan by using 2-chloro-1,3-dimethyl-imidazolinium chloride (DMC) as a dehydrative condensing agent is a relatively new way to synthesize carbohydrate derivatives. A great effort has been done to investigate the minimum requirement of bases, the suitable dehydrative

This paper presents a comprehensive cross-functional analysis of machining operations for ductile cast iron components in the automotive industry, focusing on the problem of chip carryover and its impact on downstream processes. The research aims to understand the role of machining and identify the source of the issue, by analyzing different machining sequences and the chips that affect the final

In this thesis, optimization of cross-laminated timber panels is performed. A cross laminated timber panel consists of a set of wooden layers, which are bonded together. In this work, a layer of elastomer is included among the wooden layers. As the elastomer is a favourable material to improve the vibrational and acoustic properties, this thesis investigates how this material can be optimally dist

Streptomycetes grow as filamentous cells called hyphae. These cells elongate using a polar method of growth where the cell wall synthesis is restricted to the hyphal tips. It has been proved that the protein DivIVA directs the cell wall assembly to the poles and initiate branch formation along the lateral cell wall. Observations of DivIVA shows that it is regulated by AfsK, a Ser/Thr protein kinas

This thesis examines how ideas of truth and knowledge are created, maintained, and negotiated within the context of a community through means of communication. This is achieved by conducting a case study which highlights the social processes of deconstructing and reconstructing ideas of truth. The empirical material analyzed is the podcast Another Name For Every Thing, featuring Franciscan friar F