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Abstract in UndeterminedBackground The role of allergy in the aetiopathogenesis of chronic rhinosinusitis (CRS) remains controversial. For example, in some cases with sinus fungal infections allergy can be demonstrated by standard tests. In other cases, such signs can be absent despite elevated levels of IgE-positive cells in sinus tissue and the presence of IgE and eosinophils in the sinus mucous

PURPOSE: To assess the impact of age on outcome and to analyze the projected years of life lost in patients with multiple myeloma. PATIENTS AND METHODS: Ten thousand five hundred forty-nine patients were evaluated; 6,996 patients were treated with conventional chemotherapy, and 3,553 patients were treated with high-dose therapy with autologous stem-cell transplantation. RESULTS: Mean observed and

In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not includ

Infiltration of eosinophils into the intestinal mucosa is a typical hallmark of antiparasite immune responses and inflammatory disorders of the intestinal tract, and eosinophils are thought to contribute to these processes by release of their cytotoxic granule content. However, utilizing novel tools to study eosinophils, it has been recognized that eosinophils are constitutively present in the gas

Abstract Objective: A systematic review and meta-analysis was conducted to determine the efficacy and tolerability of tacrolimus ointment for the treatment of atopic dermatitis (AD) compared with topical corticosteroids. Methods: Electronic searches were performed in Medline, Embase and the Cochrane Library, as well as relevant conference proceedings. Two researchers independently selected trials

Introduction: Intense pulsed light (IPL) treatment is well known for, for example, photo rejuvenation, where higher cut-off filters are used. The longer wavelengths penetrate deeper in the dermis leading to damage of the collagen and stimulation of new collagen formation, which lead to more soft and elastic skin. Microstomia in systemic sclerosis is the end result of excessive collagen deposition,

Lifetimes in the 3d(10)np(2)P sequence in neutral copper were measured by time-resolved laser spectroscopy. Excitation from the ground state was performed with pulsed laser radiation in the; vuv spectral region, generated by resonant sum-difference four-wave mixing in krypton gas. The lifetimes were evaluated from recorded optical transients. For the np(2)P(J) states we find the following: tau(n =

The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lip

Objective: To investigate the development of hand involvement and activities of daily life (ADL) in early systemic sclerosis (SSc), and to examine the usefulness of the Hand Mobility in Scleroderma (HAMIS) test in a longitudinal study. Methods: Forty-three patients with disease duration no longer than 3 years and at least 4 years of follow-up formed the study group. Based on skin involvement, 31 p

OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe stud

This paper extends earlier works on three-dimensional scattering from a finite obstacle in a stratified halfspace, treated by means of the T-matrix method. In this paper we consider a general source configuration above the ground, that excites the subsurface medium and its inhomogeneity. Explicit expressions are given for the magnetic dipole, the circular, and rectangular antenna loops. Numerical

CD46 is a cell surface complement inhibitor widely expressed in human tissues, in contrast to mice, where expression is limited to the testes. In humans, it has been identified as an important T cell costimulatory receptor, and patients deficient in CD46 or its endogenous ligands are unable to mount effective Th1 T cell responses. Stimulation of human CD4(+) T cells with CD3 and CD46 also leads to

PURPOSE:: To investigate retinal function and structure after recent-onset rhegmatogenous retinal detachment in relation to type of surgery. METHODS:: Thirteen consecutive patients with rhegmatogenous retinal detachment of <7 days' duration underwent vitrectomy surgery. Optical coherence tomography, full-field electroretinography (ERG), and multifocal ERG were performed preoperatively and 6 months

Genomic locus at chromosome 9p21 that contains the CDKN2A and CDKN2B tumor suppressor genes is inactivated through mutations, deletions and promoter methylation in multiple human cancers. Additionally, the locus encodes an anti-sense RNA (ANRIL). Both hemizygous and homozygous deletions at the locus targeting multiple genes are fairly common in different cancers. We in this study investigated brea