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Super-obesity, a body mass index>50 kg/m(2), is difficult to treat. Many studies have focused on the anatomic changes of the intestines; the physiologic background is not clearly identified. It is established that Roux-en-Y gastric bypass (RYGB) augments secretion of glucagon-like peptide-1 (GLP-1), peptide tyrosine tyrosine (PYY), and insulin, but other aspects of gut hormone cell function in the
The ability to control the movement of nanoparticles remotely and with high precision would have far-reaching implications in many areas of nanotechnology. We have designed a unique dynamic magnetic field (DMF) generator that can induce rotational movements of superparamagnetic iron oxide nanoparticles (SPIONs). We examined whether the rotational nanoparticle movement could be used for remote indu
The liver is a critical organ for regulation of energy homeostasis and fatty liver disease is closely associated with obesity and insulin resistance. We have previously found that lingonberries, blackcurrants and bilberries prevent, whereas açai berries exacerbate, the development of hepatic steatosis and obesity in the high-fat (HF)-fed C57BL/6J mouse model. In this follow-up study, we investigat
Increased age, BMI and HbA1c levels are risk factors for several non-communicable diseases. However, the impact of these factors on the genome-wide DNA methylation pattern in human adipose tissue remains unknown. We analyzed DNA methylation of ∼480,000 sites in human adipose tissue from 96 males and 94 females, and related methylation to age, BMI and HbA1c. We also compared epigenetic signatures i
Summary Plant communities and their ecosystem functions are expected to be more resilient to future habitat fragmentation and deterioration if the species comprising the communities have a wide range of dispersal and persistence strategies. However, the extent to which the diversity of dispersal and persistence traits in plant communities is determined by the current and historical characteristi
Recent data suggest that platelets not only control thrombosis and hemostasis but may also regulate inflammatory processes such as acute pancreatitis. However, the specific role of platelet-derived mediators in the pathophysiology of acute pancreatitis is not known. Herein, we examined the role of CD40 ligand (CD40L, CD154) in different models of acute pancreatitis. Acute pancreatitis was induced
Anxiety is an emotion, which stimulates sympathetic nervous outflow potentially facilitating vasovagal reflex syncope (VVS) but reports on anxiety levels in patients with VVS are sparse.
Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases
Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between
Reduction of energy use in buildings is an important measure to achieve climate change mitigation. It is essential to minimize heat losses when designing and building energy efficient buildings. For an energy-efficient building in a cold climate, a large part of the space heating demand is caused by transmission losses through the building envelope. Therefore, calculations of these must be carried
Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.
A warmer climate may increase the risk of attacks by insect pests on agricultural crops, and questions on how to adapt management practice have created a need for impact models. Phenological models driven by climate data can be used for assessing the potential distribution and voltinism of different insect species, but the quality of the simulations is influenced by a range of uncertainties. In th
AIMS/HYPOTHESIS: Studies have shown that dipeptidyl peptidase-4 (DPP4) inhibitors stimulate insulin secretion and increase beta cell mass in rodents. However, in these models hyperglycaemia has been induced early on in life and the treatment periods have been short. To explore the long-term effects of DPP4 inhibition on insulin secretion and beta cell mass, we have generated a high-fat diet (HFD)-
Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 an
This research explores how community-based entrepreneurs can contribute to the reorganization of natural resource management and find solutions to environmental problems within the current capitalist economy. Recent scholars on post-capitalism, believe that the economy can be organized by different institutions than the market and investigate the role of individuals as catalyst of environmenta
The dominance of men in politics has been a long standing trend, with women historically underrepresented in this sphere. Efforts toward women's inclusion in politics seek to address and rectify this gender imbalance, advocating for greater representation, equal opportunities, and the dismantling of barriers that have hindered women's active participation in political decision-making proce
Purpose: This investigation was designed to examine the effects of self-monitored training combined with the use of delayed auditory feedback (DAF), on the accuracy of articulation in acquired apraxia of speech (AOS). Background: The increased number of stroke survivors leads to higher societal costs when it comes to e.g., rehabilitation. Speech and language deficits post stroke can be diminished
Nesting phenology in birds has been studied for decades and two different breeding strategies have been identified, income and capital breeding. The nesting behaviour and the breeding strategies of 131 females were studied from three species, the Common eider (Somateria mollissima) (n = 65), known to be a capital breeder and two species the Velvet scoter (Melanitta fusca) (n = 48) and the Red-brea
