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Apolipoprotein M (apoM) is mainly associated with high-density lipoprotein in human plasma. Despite several studies suggesting apoM as an anti-atherogenic, its function is not yet fully understood. Plasma apoM was measured in normal pregnancies at four different gestational ages and in the postpartum period to investigate whether the concentration of apoM changes during pregnancy. In addition, apo

When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of ma

BACKGROUND: The prevalence of osteoporosis with related fragility fractures has increased during the last decades. As physical activity influences the skeleton in a beneficial way, exercise may hypothetically be used as a prophylactic tool against osteoporosis. OBJECTIVE: This review evaluates if exercise-induced skeletal benefits achieved during growth remain in a long-term perspective. DESIGN: P

The SNP rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein. Autoantibodies (Ab) that recognize ZnT8R, ZnT8W or both at the polymorphic site are common in newly diagnosed type 1 diabetes (T1D) patients. The epitope specificity and affinity of ZnT8Ab are poorly understood, but may be of importance for the pred

An interpretation is given of the threshold photoelectron spectrum of Ar between the P-3 and D-1 double-ionization thresholds. In this region the observed spectrum is less cluttered than below the P-3 thresholds and the interpretation is more straightforward. One of the characteristic features of the spectrum is the excitation to Rydberg orbitals with high angular momentum l in agreement with the

The pathways of melt water from a subdrained agricultural basin in southern Finland were investigated using oxygen-18 as tracer and measuring subdrainage water and total basin runoff. The flow paths for the melt water to reach the subdrains were through cracks in the ploughed layer and through regular spaced vertical sand-gravel drains. As long as the top soil was frozen a major part of the water

A prevailing question in phytoplankton research addresses changes of genetic diversity in the face of huge population sizes and apparently unlimited dispersal capabilities. We investigated population genetic structure of the pennate planktonic marine diatom Pseudo-nitzschia multistriata at the LTER station MareChiara in the Gulf of Naples (Italy) over four consecutive years and explored possible c

The GW approximation for the self-energy connected with the one-electron Green's function has been very successful in predicting band structures for a large class of semiconductors and insulators. The physical basis for this approximation and general features of its nonlocality are discussed, as well as possible improvements. Besides quasiparticle energies the self-energy also gives the intrinsic

A 38-year record of bottom water dissolved oxygen concentrations in coastal marine ecosystems around Denmark (1965-2003) and a longer partially reconstructed record of total nitrogen (TN) inputs (1900-2003) were assembled to describe long-term patterns in hypoxia and anoxia. Interannual variations in bottom water oxygen concentrations were analyzed in relation to various explanatory variables (bot

BACKGROUND: The extent of site and tissue-associated immune privilege is of great interest in transplantation experiments involving the CNS. In the present paper we have explored neuroretinal immune privilege by transplantation to a non-immune privileged site. METHODS: Fetal and adult full-thickness rabbit neuroretinal grafts were placed in the subconjunctival space of immunocompetent rabbit hosts

Purpose. To create a retina consisting mainly of photoreceptors for future use as donor tissue in retinal transplantation. Methods. Fetal full-thickness neuroretinas from Sprague Dawley rats 17 (E17) or 20 (E20) days post conception were placed in culture for 7 or 14 days. Explants and age-matched control retinas were examined by light microscopy and with a panel of immunohistochemical markers lab

Miller M, Flansbjer U-B, Lexell J: Voluntary activation of the knee extensors in chronic poststroke subjects. OBJECTIVE:: To assess the extent to which knee extensor muscle weakness in subjects with chronic mild to moderate poststroke hemiparesis is caused by a decreased voluntary activation. DESIGN:: Forty community dwelling and ambulant men and women (mean age, 59.8 +/- 5.5 yrs) with residual he

The quality of spatial analyses of biodiversity is improved by (i) utilizing study areas with well defined physiogeographical boundaries, (ii) limiting the impact of widespread species, and (iii) using taxa with heterogeneous distributions. These conditions are typically met by ecosystems such as oceanic islands or ancient lakes and their biota. While research on ancient lakes has contributed sign